COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

Tranexamic acid is effective in reducing blood loss, while maintaining safety, in THA

Arch Orthop Trauma Surg. 2013 Jul;133(7):1017-27. doi: 10.1007/s00402-013-1761-2. Epub 2013 Apr 25

AAOS 2016: Interim evaluation of tranexamic acid vs placebo in acetabular fracture surgery

Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

AAOS 2016: TXA vs. epsilon-aminocaproic acid provide comparable outcomes after TKA

AAOS2018: TXA effective in operative management for high-energy pelvic and femoral fractures

Intravenous TXA prior to tourniquet inflation more efficacious compared to later timepoints

J Arthroplasty. 2017 Jan;32(1):33-36

Efficacy of various tranexamic acid administration techniques to reduce blood loss in TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Dec;22(12):3181-90.

AAOS2018: IV TXA reduced blood loss in total shoulder arthroplasty

Equivalent blood conservation with intra-articular and intravenous TXA in TKA

J Bone Joint Surg Am. 2014 Dec 3;96(23):1937-44

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

AAOS2017: Tranexamic acid appears safe and effective in fracture surgery

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

IV tranexamic acid reduces blood loss and transfusion rate in primary THA

Orthopedics. 2016 Sep 1;39(5):e883-92

Similar effect of intra-articular vs IV TXA on Hb drop, LoS, and transfusion following TKA

J Arthroplasty. 2017 Jan;32(1):28-32

AAOS: Tranexamic acid equally effective when administered topically & intravenously in TKA

Combined IV-topical TXA versus IV TXA alone in patients undergoing revision THA

J Arthroplasty. 2016 Nov;31(11):2548-2553

AAOS 2016: Intravenous and topical TXA yield similar efficacy and safety in THA

Blood loss and transfusion needs reduced with TXA in major orthopaedic surgery

J Surg Res. 2014 Jan;186(1):318-27. doi: 10.1016/j.jss.2013.08.020. Epub 2013 Sep 13

Low-dose tranexamic acid does not reduce blood loss or transfusion rate in spinal surgery

J Neurosurg Anesthesiol. 2011 Oct;23(4):290-6. doi: 10.1097/ANA.0b013e31822914a1