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8%
Synopsis: 303 patients with peripheral neuropathic pain (PNP) were randomized to either Nabiximols or placebo for 14 weeks.Significant improvements in pain, quality of sleep and Subject Global Impression of Change (SGIC) were found in patients that received Nabiximols compared to those that received placebo. No patients experienced... Read More »
Level 1 RCT
5%
Synopsis: 66 patients with central neuropathic pain due to multiple sclerosis (MS) were randomly assigned to receive either cannabis-based medicine (CBM) through oromucosal spray or placebo for 4 weeks.Participants were assessed on pain severity, sleep disturbances, the impression of change, the incidence of adverse events, cognitive abilities, mood, and MS-related disability at the beginning and end of the study.Results demonstrated that oromucosal administration of CBM was effective in improving pain, sleep disturbance compared to placebo. The incidence of... Read More »
Level 1 RCT
2%
Synopsis: 32 patients with osteochondral lesions of the talus, that were unresponsive to other non-operative treatment modalities, were randomized to injections with platelet-rich plasma (PRP) using a plasma rich in growth factors technique (PRGF) or hyaluronic acid (HA). Follow-up at 4, 14, and 28 weeks after the injection indicated that PRP is a safe and efficacious treatment for osteochondral lesions producing a number superior clinical and subjective results when compared to HA. Read More »
Author verified Level 2 RCT
2%
Synopsis: 149 patients (168 heels) with chronic plantar fasciitis were randomized to receive extracorporeal shockwave treatment or conservative treatment consisting of non-steroidal anti-inflammatory drugs, orthotics, physical therapy, an exercise program and/or a local cortisone injection.Over 5 to 6 years, patients in the shockwave group had significantly greater improvements in pain and function than the conservative treatment group.The patients who received shockwave therapy were also significantly less likely to experience a recurrence of symptoms compared to the conservative treatment group. The results therefore... Read More »
Level 2 RCT
2%
Synopsis: 59 patients diagnosed with the condition lateral epicondylitis (LE), were randomised into three groups to undergo either physical therapy, a single corticosteroid injection, or extracorporeal shock wave treatment (ESWT), to determine which technique was the most effective in treating LE.Following assessments measured over 6 months, results displayed that all three methods used for LE treatment had positive outcomes regarding reduction in pain and an increase in grip strength in early stages. However, there were... Read More »
Level 2 RCT
2%
Synopsis: In this systematic review, 33 cohort studies (consisting of 11,166 participants) examining the clinical course of pain and disability in patients suffering from acute and persistent low-back pain were evaluated.Pooled results demonstrated that by 6 weeks, patients experienced a significant improvement in pain and disability. However, beyond those... Read More »
Author verified Level 2 Meta Analysis
2%
Synopsis: 72 patients were randomized to compare the efficacy of Platelet Rich Plasma (PRP) or hyaluronic acid (HA) for the treatment of chondropathy or early knee osteoarthritis (OA).Results at the 6-month follow-up revealed that both groups displayed a significant improvement in regards to function and quality of life. However, there were... Read More »
Conference Report
2%
Synopsis: 198 patients with plantar fasciitis were randomized to receive 1 of 3 treatment modalities to determine the efficacy of a novel foot brace (the EZstep) in alleviating heel pain.Patients either received nonsteroidal anti-inflammatory drugs (NSAIDs) and wore an EZStep foot brace, or received NSAIDs while undergoing physiotherapy, or received NSAIDs, physiotherapy, and local steroid injections. Following assessments over... Read More »
Author verified Level 2 RCT
2%
Synopsis: Six ACE Reports (5 randomized controlled trials and 1 systematic review/meta-analysis) were identified from the OrthoEvidence database which evaluated the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis.All included studies were randomized controlled trials, and reported clinical and functional assessment at various time points between 1 and 6 months following treatment.Pooled analysis of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Total scores suggested a possible beneficial effect with PRP injection in comparison to saline and a lower effect versus hyaluronic acid.Beneficial effects were also noted for individual subscales of the WOMAC assessment (pain, stiffness, and physical function).However, pooling of OMERACT-OARSI responders and a review of the literature indicated that there was no significant difference between PRP and comparison groups in other functional outcome measures, such as the International Knee Documentation Committee (IKDC) assessment and Knee Injury and Osteoarthritis Outcome Score (KOOS).Furthermore, contrasting results were obtained between two studies reporting function on the Lequesne Index. The discrepancy in... Read More »
ACE Review
2%
Synopsis: 17 randomized controlled trials (RCTs) consisting of 1381 patients with tennis elbow were evaluated to compare 8 types of injection therapies with the goal of determining the efficacy and safety of each.Results indicated that patients treated with autologous blood, platelet-rich plasma, prolotherapy, hyaluronic acid, and botulinum toxin injections experienced significant improvements in pain intensity compared to placebo.There were no significant differences between any of the glucocorticoid, polidocanol, or glycosaminoglycan polysulfate injection therapy groups against a respective placebo, where changes in pain intensity were concerned.Additionally, no serious adverse events were reported in any of the patients, but the most common minor adverse event observed was temporary pain following administration of injections. This meta-analysis strongly... Read More »
Author verified Level 1 Meta Analysis