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7%
Synopsis: 26 randomized controlled trials were included in this meta-analysis which compared efficacy and safety outcomes of glucosamine monotherapy, chondroitin monotherapy, and combined therapy to placebo.A total of 30 distinct comparison were available among the included studies, with follow-up ranging from 4 weeks to 144 weeks.Pooled estimates demonstrated significant effects of chondroitin on pain and function measures compared to placebo, while glucosamine demonstrated significant a significant effect on stiffness measures.Combined therapy failed to demonstrate a significant effect compared to placebo for any efficacy measures. No significant differences... Read More »
Level 2 Meta Analysis
6%
Synopsis: 356 patients who presented to primary care with traumatic knee symptoms were randomized to either receive a referral for MRI by the general practitioner, or to usual care as per the Dutch clinical guideline with potential referral to an orthopaedic surgeon.The purpose of this study was to determine if a referral for MRI from primary care was a cost-effective treatment pathway for this patient population. Assessment of cost-utility... Read More »
Level 2 RCT
3%
Synopsis: 82 patients with a complete Achilles tendon rupture were randomized to either percutaneous repair or open repair.Follow-up was performed over 12 months after surgery for functional scores, range of motion, complications, and rerupture rate.Results demonstrated no significant differences between groups for any of the assessed outcome measures. No patient in... Read More »
Author verified Level 2 RCT
3%
Synopsis: 44 patients with Achilles tendinopathy were randomized to an ultrasound-guided injection of either an adipose-derived stromal vascular fraction or leukocyte-rich platelet-rich plasma.Outcome measures included a visual analog scale for pain, the Victorian Institute of Sport Assessment-Achilles (VISA-A) questionnaire, the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score, and MRI-measured tendon lesion size.Follow-up was performed at 15 days, 30 days, 60 days, 120 days, and 180 days.Both treatments allowed for a significant improvement with respect to baseline, with stable results up to the last follow-up.Results demonstrated significantly better scores in the SVF group at 15 days for VAS pain and AOFAS ankle-hindfoot scores, and at 30 days for the VISA-A; at all other time points, groups did not significantly differ. No significant within-group... Read More »
Author verified Level 2 RCT
3%
Synopsis: Four randomized controlled trials were included in this meta-analysis which aimed to evaluate the effect of platelet-rich plasma injections in addition to eccentric exercises relative to saline injections in addition to eccentric exercise. Pooled results on VISA-A scores, tendon thickness, and color Doppler activity demonstrated no significant differences between PRP and saline injections groups. Read More »
Level 1 Meta Analysis
3%
Synopsis: 69 patients with a closed, displaced clavicle fracture (Robinson type 2B) were randomized to surgery with open reduction and internal fixation with a plate, or two nonoperative treatment with an arm pouch sling.Patients were followed over 24-month follow-up for union, incidences of nonunion and malunion, complications, and function through the Constant score.Results demonstrated no significant differences in the rate of nonunion between groups, though time to union was significantly shorter in the plate group compared to sling group. Additionally, function at... Read More »
Level 2 RCT
2%
Synopsis: 29 randomized controlled trials were selected for inclusion in this meta-analysis which compared the rates of heterotopic ossification after total hip arthroplasty between groups of patients treated with selective non-steroidal anti-inflammatory drugs (NSAIDs), groups treated with non-selective NSAIDS, and groups treated with placebo.Compared to placebo, both selective and non-selective NSAID groups demonstrated significantly lower rates of heterotopic ossification development. No significant difference... Read More »
Level 1 Meta Analysis
2%
Synopsis: 44 patients with a stable type B malleolar fracture were randomized to postoperative immobilization using either a removable functional brace or a below-the-knee cast.Patients were assessed for function, pain, comfort, and range of motion over a 52 week follow-up.Results demonstrated no significant differences between groups at any time point on the Olerud-Molander score, VAS pain, or AAOS foot and ankle score. VAS comfort scores... Read More »
Author verified Level 2 RCT
2%
Synopsis: Nineteen randomized controlled trials were included in this meta-analysis which sought to evaluate the efficacy of extracorporeal shockwave therapy for various soft-tissue knee disorders.Main analyses and various subgroup analyses were performed on results related to treatment success rate, pain reduction from baseline, and functional outcome.Overall, ESWT was associated with greater treatment success rates, pain reduction, and functional outcome compared to control interventions. Radial ESWT demonstrated... Read More »
Level 2 Meta Analysis
2%
Synopsis: 25 randomized controlled trials were included in this meta-analysis which compared bisphosphonate therapy to control intervention for effect on postoperative bone mineral density following total hip and total knee arthroplasty.Overall, in THA and TKA cohorts, bisphosphonate therapy was associated with significantly greater total periprosthetic bone mineral density compared to control intervention up to 5-10 year follow-up. Among THA cohorts,... Read More »
Level 1 Meta Analysis