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You are viewing the most viewed ACE Reports by Sports Medicine Specialists over the last 30 days in all specialties.
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Platelet-Rich Plasma Injections Are Inferior to Corticosteroid Injections for Short-Term Pain Relief
①
Synopsis:
Fifty-two patients with symptomatic KL II–III knee osteoarthritis (OA) were randomized to receive platelet-rich plasma (PRP) (n=26) or corticosteroid (CS) (n=26).The primary outcome was change in VAS pain.Secondary outcomes were NPRS pain, KOOS JR, and WOMAC.Outcomes were assessed at baseline, 6 weeks, and 3 months.Overall, the results of the study revealed that CS produced significantly larger pain reductions than PRP at 6 weeks and met MCIDs for both VAS and NPRS, whereas groups were similar by 3 months and showed comparable functional gains at both time points. These findings suggest...
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Level 1 RCT
8%
①
Synopsis:
Sixty athletes with MRI-confirmed grade 2 hamstring injuries were randomized to receive ultrasound-guided Platelet-Rich Plasma (PRP) injections plus standard therapy (n=30) or standard therapy alone (n=30).The primary outcome of interest was time to return to play.Secondary outcomes included MRI healing at 21 days, re-injury rates, and adverse events, with follow-up extending to 24 months.Overall, the results of the study revealed that PRP significantly accelerated return to play, improved MRI healing at 21 days, and trended toward lower re-injury rates.No adverse events occurred. These findings suggest...
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Level 1 RCT
7%
①
Synopsis:
Nine hundred fourty one patients with carpal tunnel syndrome (CTS) were randomized to receive initial surgical decompression (n=470) or initial corticosteroid injection (n=471); further interventions were allowed in both arms as needed.The primary outcome was recovery at 18 months (CTS-6 <8).Secondary outcomes included time to recovery, serial CTS-6, upper-limb function (QuickDASH), palmar pain and pain-related limitation, global perception of recovery, satisfaction, additional treatments, and adverse events.Outcomes were assessed through 18 months at prespecified intervals.Overall, the results of the study revealed that 61% in the surgery group versus 45% in the injection group recovered, and median time to recovery was shorter with surgery (9.0 vs 18.0 months).Patients starting with surgery also had better 18-month QuickDASH, global recovery, and satisfaction, while palmar pain was more frequent early after surgery but comparable by later follow-up. These findings suggest...
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Level 1 RCT
6%
①
Synopsis:
One hundred thirty-two patients with Kellgren-Lawrence grade 1-3 knee osteoarthritis were randomized to receive three weekly intra-articular injections of either LR-PRP (n=66) or LP-PRP (n=66).The primary outcome was the change in the International Knee Documentation Committee (IKDC) subjective score at 12 months.Secondary outcomes included pain, function, and quality of life assessed through various scales (KOOS, WOMAC, VAS, EQ-5D, Tegner activity scale), as well as objective measures such as range of motion and quadriceps circumference.Outcomes were evaluated at baseline and at 2, 6, and 12 months.Overall, both groups showed significant improvement in subjective and objective outcomes, with no significant differences except for a transient greater improvement in IKDC at 2 months in the LR-PRP group, and minor differences in ROM and quadriceps circumference at specific time points.No severe adverse events were reported, and the rate of treatment failure was similar. The study concluded...
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Level 1 RCT
6%
②
Synopsis:
Nine studies (6 randomized controlled trials and 3 prospective comparative studies) were selected to examine the effects of leukocyte-poor platelet rich plasma and leukocyte-rich platelet rich plasma in knee osteoarthritis treatment.Due to the presence of only one direct comparison between LP-PRP and LR-PRP at the time of the study, studies which compared either to hyaluronic or placebo were included, and network meta-analysis was undertaken.Primary outcome was the incidence of local adverse events, while secondary efficacy outcomes included the change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and International Knee Documentation Committee (IKDC) scores.Incidence of local adverse events was higher with LP-PRP or LR-PRP compared to HA or placebo, and both were ranked at approximately 20% of being the best treatment for the outcome.Nevertheless, the difference between LP-PRP and LR-PRP for incidence of local adverse events was not significant. LP-PRP was ranked...
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Author verified Level 2 Meta Analysis
6%
①
Synopsis:
Ninety patients with intra-articular hip disorders, mainly osteoarthritis, were randomized to receive fluoroscopy-guided intra-articular steroid injection via the anterior approach (n=30), the anterolateral approach (n=30), or the proximal anterolateral approach (n=30).The primary outcome was successful injection in a single attempt.Secondary outcomes included pain during injection (VAS), radiation exposure, complications, and short-term functional improvement measured by the modified Harris hip score (mHHS).Outcomes were assessed at baseline and 2 weeks post-injection.Overall, the results revealed no significant differences between approaches in single-attempt success, VAS pain, radiation exposure, or mHHS improvement. The study concludes...
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Level 1 RCT
4%
②
Synopsis:
1184 Computer workers from 7 Dutch organizations partook a health questionnaire were randomized to two groups, one receiving the feedback on their scores and a preventive advice and the other group continuing with the usual care. The effectiveness of the RSI QuickScan intervention program was found to be small and limited to a decrease in some risk factors exposures only, with no difference in the prevalence of symptoms or sick leave between the groups.
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Author verified Level 2 RCT
3%
①
Synopsis:
One hundred fifty-two patients with non-specific chronic low back pain (CLBP) were randomized to receive individualized cognitive functional therapy (CFT)(n=76) or a sham intervention (neutral talking plus detuned low-level laser; n=76).The primary outcomes were pain intensity (0–10) and Oswestry Disability Index (0–100) at 6 weeks.Secondary outcomes included pain and disability at 3 and 6 months, functioning, pain self-efficacy, global perceived effect, and analgesic use.Outcomes were assessed pre-treatment, post-treatment (6 weeks), and at 3 and 6 months.Overall, the results revealed clinically meaningful, statistically significant advantages for CFT over sham at 6 weeks that persisted through 6 months. In short, CFT...
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Level 1 RCT
3%
①
Synopsis:
Thirty two patients with full-thickness posterosuperior rotator cuff tears were randomized to immobilization with an abduction neutral-rotation brace (n=16 analyzed) or a conventional arm sling (n=16).The primary outcomes were passive shoulder ROM (forward flexion, external rotation, internal rotation) measured serially; secondary outcomes were pain (VAS) and Constant–Murley Score (CMS).Outcomes were assessed preoperatively and at 6 weeks, 3, 6, and 12 months.Overall, the results revealed better early ROM (e.g., forward flexion and external rotation at 3 months) and lower pain at 6 weeks with the brace, while 12-month ROM converged and CMS was only modestly higher in the brace group at 12 months. These findings suggest...
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Level 1 RCT
3%
①
Synopsis:
Ninety patients with knee osteoarthritis were randomized to acupuncture (n=30), sham acupuncture (n=30), or waiting list (n=30).Patients received twelve 30-minute sessions over 4 weeks.The primary outcome was response (≥2-point NRS reduction at week 4).Secondary outcomes included changes in NRS, WOMAC, STAI-S, and fMRI metrics: ALFF (resting-state spontaneous activity) and seed-based functional connectivity (FC) centered on regions identified by ALFF.Outcomes were assessed at baseline and 4 weeks.Overall, the results revealed higher response with acupuncture (85.2%) versus sham (52%) and waiting (13.6%), greater NRS improvement with acupuncture versus sham, dorsolateral prefrontal cortex (DLPFC) ALFF decreases with both acupuncture and sham, stronger DLPFC–thalamus FC increases with acupuncture, and DLPFC–cerebellum FC decreases with sham. These findings suggest...
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Level 1 RCT