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Synopsis: Seven randomized controlled trials including 658 patients with intertrochanteric femur fractures were included in this systematic review and meta-analysis comparing short versus long cephalomedullary nails (CMN).Pooled outcomes of interest included Harris hip score, 1-year mortality, overall complication rates, reoperation rates, duration of surgery, intraoperative blood loss, tip-apex distance, and hospital stay length.The pooled results showed no significant differences in Harris hip score, mortality, complications, or reoperations.However, short nails were associated with shorter surgery time, lower blood loss, and reduced tip-apex distace. These findings suggest... Read More »
Level 1 Meta Analysis
7%
Synopsis: 28 elderly patients with acute distal femur fractures or periprosthetic fractures of the hip or knee were randomized to receive either far cortical locking (FCL; n=16) or standard locking plate fixation (LPF; n=12).Outcomes of interest included the radiographic union scale (RUS) and time to union. RUS scores at... Read More »
Level 1 RCT
5%
Synopsis: One hundred seventy-two patients undergoing total knee arthroplasty for osteoarthritis were randomized to receive either 5 mg melatonin (n=86) or 125 mg vitamin C placebo (n=86).The primary outcome was the Pittsburgh Sleep Quality Index (PSQI).Secondary outcomes included patient-reported measures of pain and physical function, opioid prescriptions, medication compliance, and adverse events.Outcomes were assessed at both 6 weeks and 90 days.Overall, the results showed no significant differences in PSQI or secondary outcomes between the melatonin and placebo groups at either time point. The findings suggest... Read More »
Level 1 RCT
3%
Synopsis: 144 patients with primary complete Achilles tendon rupture were randomized to be treated with either a surgical repair and accelerated functional rehabilitation or with only the accelerated functional rehabilitation. Over the course of a two year follow up, it was observed that Achilles tendon rupture led to clinically similar results between the two treatment groups. Read More »
Level 2 RCT
3%
Synopsis: 154 patients with Dupuytren's disease were randomized to receive hand therapy either with or without nightly splinting for 6 months following fasciectomy or dermofasciectomy, in order to determine if splinting provided a beneficial effect to patients 1 year postoperatively.Patients were primarily assessed with the Disabilities of the Arm, Hand, and Shoulder questionnaire, and secondarily through total active flexion, total active extension, and patient satisfaction.The results of the study reflected no significant differences between the primary outcome or any of the secondary outcomes, and that there was no beneficial effect of nightly splinting combined with hand therapy. Read More »
Author verified Level 2 RCT
3%
Synopsis: 186 patients with a severe lateral ankle sprain (type III) were randomized to treatment to 3 weeks of rigid immobilization with a walking boot followed by 3 weeks of immobilization with a functional brace, or to a functional brace for 6 weeks.The purpose was to compare these two conservative treatment methods for outcomes in pain, function, and ankle stability up to 12 weeks after the injury.AOFAS scores were better for the first 6 weeks in patients receiving the functional brace, and pain and comfort outcomes also benefited within the first few weeks from using a functional brace. By 12 weeks,... Read More »
Author verified Level 2 RCT
3%
Synopsis: High quality evidence has revealed that non-operative management of acute Achilles tendon rupture achieves optimal outcomes in most patients.Among non-operative treatment options, the most commonly used are functional bracing (walking boot with heel wedges) and casting in equinus position.There has been a recent move towards early mobilization and more use of functional bracing over casts in a number of different areas, and it is unclear if there is a benefit in favour of either strategy in the context of Achilles tendon ruptures.In this study, the authors randomized patients to plaster cast versus functional bracing, and performed an accompanying economic evaluation.They found that patients treated with functional brace had significantly better functional scores at eight weeks, and that bracing was dominant from a cost-effectiveness perspective, with modest savings and slightly better utility. There was no... Read More »
Level 1 RCT
3%
Synopsis: One hundred four patients with end-stage hip joint diseases undergoing primary total hip arthroplasty were randomized to receive intraoperative bone wax (n=52) or no bone wax (n=52).The primary outcome was total blood loss.Secondary outcomes included serum hemoglobin level, change in hemoglobin, thigh swelling (lower limb diameters), range of motion at discharge, length of postoperative hospital stay, and adverse events.Outcomes were assessed on postoperative days (POD) 1 and 3, and during follow-up at 3 weeks and 6 months.Overall, the results of the study revealed significantly lower total blood loss, smaller hemoglobin drop, and shorter hospital stays in the bone wax group. The study concludes... Read More »
Level 1 RCT
3%
Synopsis: Five randomized controlled trials (189 patients) comparing platelet-rich plasma (PRP) against conservative treatment for chronic Achilles tendinopathy were included in this systematic review and meta-analysis.Outcomes of interest included the Victorian Insitute of Sport Assessment (VISA-A) score, pain during activity on a Visual Analog Scale (VAS), and Achilles tendon thickness.VISA-A scores at 6 weeks favored the PRP group.Tendon thickness also favored the PRP group. All other outcomes... Read More »
Level 1 Meta Analysis
3%
Synopsis: Forty-seven patients with single-level cervical radiculopathy were randomized to receive either BRYAN CDA (cervical disk arthroplasty; n=22) or ACDF (anterior cervical discectomy and fusion; n=25) in a prospective, randomized, controlled trial conducted as a Food and Drug Administration Investigational Device Exemption trial.The primary outcomes of interest included visual analog scales (VAS) for neck and arm pain, neck disability index (NDI), and reoperation rates.The follow-up rate was 91.3%.Both groups demonstrated significantly improved NDI, VAS arm pain, and VAS neck pain scores at 20 years compared to preoperative scores.However, there were no significant differences between CDA and ACDF groups at 20 years for NDI, VAS arm pain, and VAS neck pain scores.Reoperations were reported in 41.7% of ACDF patients and 10.0% of CDA patients. Both CDA and... Read More »
Level 1 RCT