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Synopsis: A meta analysis was performed to clarify the efficacy of various venous thromboembolism prophylaxis methods.The results of fifty-six independent trials across 91 treatment groups involving different combinations of treatment and 35 control groups were identified and analysed. The results suggest... Read More »
Level 1 Meta Analysis
16%
Synopsis: Data from 14 Level I or Level II randomized controlled trials (N=4726) was gathered in this meta-analysis.The aim of this study was to assess the efficacy of low-molecular-weight heparin venous thromboprophylaxis versus placebo/no treatment in non-major orthopaedic patients with transient reduced mobility. Findings indicated significant... Read More »
Author verified Level 1 Meta Analysis
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Synopsis: 300 patients scheduled for total knee arthroplasty (TKA) were randomized to receive Factor XI Antisense Oligonucleotide (FXI-ASO) 200 mg, FXI-ASO 300 mg, or enoxaparin 40 mg.This was done to evaluate the safety and efficacy of FXI-ASO in the reduction of risk of venous thromboembolism (VTE) in patients following surgery.Patient outcomes were measured through venography at day 10 +/- 2, to determine the presence of VTE, and through the occurrence of clinically relevant bleeding. Results indicated that... Read More »
Author verified Level 2 RCT
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Synopsis: 18 randomized controlled trials were included in this meta-analysis evaluating the efficacy and safety of newer anticoagulants compared to enoxaparin in total knee and total hip arthroplasty.Anticoagulants evaluated included apixaban, dabigatran, fondaparinux, rivaroxaban, and edoxaban.The only newer anticoagulant which failed to demonstrate a significant reduction in VTE incidence relative to enoxaparin was dabigatran at both 150mg and 220mg once daily doses. Of the remaining... Read More »
Level 1 Meta Analysis
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Synopsis: 110 patients scheduled for a primary unilateral total knee arthroplasty (TKA) were randomized to receive an immediate or delayed physiotherapy protocol following surgery.Outcomes of interest included the Knee Injury and Osteoarthritis Outcome Score (KOOS), VR-12 scores, visual analog scale (VAS) pain scores, range of motion, number of therapy visits, the Timed Up and Go (TUG) test, and rate of manipulation.Follow up was performed at 6 weeks and 6 months. Results from the... Read More »
Conference Report
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Synopsis: The use of anticoagulants for lower limb outpatient procedures such as knee arthroscopy is varied, and questions remain.The authors performed a meta-analysis of nine randomized controlled trials. The interventions included low molecular weight heparin (LMWH), Rivaroxaban, and acetylsalicylic acid (ASA), and comparators included no treatment, placebo, and compression stockings.A total of 4290 patients were included.Overall, they found no significant difference between pharmacologic interventions and controls in terms of symptomatic venous thromboembolism (excluding distal deep vein thrombosis (DVT)).There were significantly fewer symptomatic distal DVTs in the treatment group. Overall, the authors... Read More »
Level 1 Meta Analysis
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