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You are viewing the most viewed ACE Reports by Sports Medicine Specialists over the last 30 days in all specialties.
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Platelet-Rich Plasma Injections Are Inferior to Corticosteroid Injections for Short-Term Pain Relief
①
Synopsis:
Fifty-two patients with symptomatic KL II–III knee osteoarthritis (OA) were randomized to receive platelet-rich plasma (PRP) (n=26) or corticosteroid (CS) (n=26).The primary outcome was change in VAS pain.Secondary outcomes were NPRS pain, KOOS JR, and WOMAC.Outcomes were assessed at baseline, 6 weeks, and 3 months.Overall, the results of the study revealed that CS produced significantly larger pain reductions than PRP at 6 weeks and met MCIDs for both VAS and NPRS, whereas groups were similar by 3 months and showed comparable functional gains at both time points. These findings suggest...
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Level 1 RCT
8%
①
Synopsis:
Sixty athletes with MRI-confirmed grade 2 hamstring injuries were randomized to receive ultrasound-guided Platelet-Rich Plasma (PRP) injections plus standard therapy (n=30) or standard therapy alone (n=30).The primary outcome of interest was time to return to play.Secondary outcomes included MRI healing at 21 days, re-injury rates, and adverse events, with follow-up extending to 24 months.Overall, the results of the study revealed that PRP significantly accelerated return to play, improved MRI healing at 21 days, and trended toward lower re-injury rates.No adverse events occurred. These findings suggest...
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Level 1 RCT
7%
①
Synopsis:
One hundred thirty-two patients with Kellgren-Lawrence grade 1-3 knee osteoarthritis were randomized to receive three weekly intra-articular injections of either LR-PRP (n=66) or LP-PRP (n=66).The primary outcome was the change in the International Knee Documentation Committee (IKDC) subjective score at 12 months.Secondary outcomes included pain, function, and quality of life assessed through various scales (KOOS, WOMAC, VAS, EQ-5D, Tegner activity scale), as well as objective measures such as range of motion and quadriceps circumference.Outcomes were evaluated at baseline and at 2, 6, and 12 months.Overall, both groups showed significant improvement in subjective and objective outcomes, with no significant differences except for a transient greater improvement in IKDC at 2 months in the LR-PRP group, and minor differences in ROM and quadriceps circumference at specific time points.No severe adverse events were reported, and the rate of treatment failure was similar. The study concluded...
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Level 1 RCT
7%
①
Synopsis:
Nine hundred fourty one patients with carpal tunnel syndrome (CTS) were randomized to receive initial surgical decompression (n=470) or initial corticosteroid injection (n=471); further interventions were allowed in both arms as needed.The primary outcome was recovery at 18 months (CTS-6 <8).Secondary outcomes included time to recovery, serial CTS-6, upper-limb function (QuickDASH), palmar pain and pain-related limitation, global perception of recovery, satisfaction, additional treatments, and adverse events.Outcomes were assessed through 18 months at prespecified intervals.Overall, the results of the study revealed that 61% in the surgery group versus 45% in the injection group recovered, and median time to recovery was shorter with surgery (9.0 vs 18.0 months).Patients starting with surgery also had better 18-month QuickDASH, global recovery, and satisfaction, while palmar pain was more frequent early after surgery but comparable by later follow-up. These findings suggest...
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Level 1 RCT
6%
②
Synopsis:
Nine studies (6 randomized controlled trials and 3 prospective comparative studies) were selected to examine the effects of leukocyte-poor platelet rich plasma and leukocyte-rich platelet rich plasma in knee osteoarthritis treatment.Due to the presence of only one direct comparison between LP-PRP and LR-PRP at the time of the study, studies which compared either to hyaluronic or placebo were included, and network meta-analysis was undertaken.Primary outcome was the incidence of local adverse events, while secondary efficacy outcomes included the change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and International Knee Documentation Committee (IKDC) scores.Incidence of local adverse events was higher with LP-PRP or LR-PRP compared to HA or placebo, and both were ranked at approximately 20% of being the best treatment for the outcome.Nevertheless, the difference between LP-PRP and LR-PRP for incidence of local adverse events was not significant. LP-PRP was ranked...
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Author verified Level 2 Meta Analysis
6%
①
Synopsis:
Ninety patients with intra-articular hip disorders, mainly osteoarthritis, were randomized to receive fluoroscopy-guided intra-articular steroid injection via the anterior approach (n=30), the anterolateral approach (n=30), or the proximal anterolateral approach (n=30).The primary outcome was successful injection in a single attempt.Secondary outcomes included pain during injection (VAS), radiation exposure, complications, and short-term functional improvement measured by the modified Harris hip score (mHHS).Outcomes were assessed at baseline and 2 weeks post-injection.Overall, the results revealed no significant differences between approaches in single-attempt success, VAS pain, radiation exposure, or mHHS improvement. The study concludes...
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Level 1 RCT
4%
②
Synopsis:
1184 Computer workers from 7 Dutch organizations partook a health questionnaire were randomized to two groups, one receiving the feedback on their scores and a preventive advice and the other group continuing with the usual care. The effectiveness of the RSI QuickScan intervention program was found to be small and limited to a decrease in some risk factors exposures only, with no difference in the prevalence of symptoms or sick leave between the groups.
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Author verified Level 2 RCT
4%
①
Synopsis:
One hundred fifty-two patients with non-specific chronic low back pain (CLBP) were randomized to receive individualized cognitive functional therapy (CFT)(n=76) or a sham intervention (neutral talking plus detuned low-level laser; n=76).The primary outcomes were pain intensity (0–10) and Oswestry Disability Index (0–100) at 6 weeks.Secondary outcomes included pain and disability at 3 and 6 months, functioning, pain self-efficacy, global perceived effect, and analgesic use.Outcomes were assessed pre-treatment, post-treatment (6 weeks), and at 3 and 6 months.Overall, the results revealed clinically meaningful, statistically significant advantages for CFT over sham at 6 weeks that persisted through 6 months. In short, CFT...
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Level 1 RCT
1%
①
Synopsis:
One hundred twenty-eight patients with knee osteoarthritis were randomized to receive prolotherapy with 5% dextrose (n=30), 10% dextrose (n=30), 20% dextrose (n=30), or exercise plus hotpack only (n=30).All prolotherapy groups received three injection sessions at weeks 0, 3, and 6, combined with a home exercise program and hotpack therapy.The primary outcome was pain assessed by VAS.Secondary outcomes included WOMAC scores, knee range of motion, timed up and go (TUG) test, and SF-36 quality of life scores.Outcomes were measured at baseline, 6 weeks, and 12 weeks.Overall, results showed that 10% and 20% dextrose groups had significantly greater pain reduction and functional improvements compared with exercise alone, while 20% dextrose also improved knee flexion. The findings suggest...
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Level 1 RCT
1%
Five-Year Stability of Cementless 3D-Printed vs Cemented Tibial Components - Total Knee Arthroplasty
①
Synopsis:
Seventy-two patients with knee osteoarthritis were randomized to receive a cementless 3D-printed cruciate-retaining tibial component (n=36) or a cemented cruciate-retaining tibial component (n=36).The primary outcome was maximum total point motion (MTPM) of the tibial component at 5 years.Secondary outcomes included progression of migration between 2 and 5 years, the proportion of continuously migrating implants, and patient-reported outcomes (KSS, KOOS, FJS).Follow-up assessments were performed at baseline, 3 months, 1, 2, and 5 years.Overall, the results revealed no significant difference in mean MTPM between cementless and cemented groups at 5 years.Progression of migration occurred in the cemented group beyond 2 years, whereas the cementless implants stabilized after early migration.Clinical outcomes were comparable between groups. These findings suggest...
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Level 1 RCT