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41%
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13%
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100%
13%
Synopsis: 82 patients, 40-80 years of age, with knee osteoarthritis were randomized to treatment with either hyaluronic acid injections or a physical therapy program.Patients allocated to hyaluronic acid injections were administered either high-molecular-weight HA (Hylan G-F20) or low-molecular-weight HA (Orthovisc). Results demonstrated significant... Read More »
RCT
5%
Synopsis: 102 patients with carpal tunnel syndrome were randomized to receive either an ultrasound-guided or landmark-based corticosteroid injection.Outcomes of interest included the Boston Carpal Tunnel Questionnaire (BCTQ) Symptom and Function scores, grip strength, rate of surgical treatment following injection, and adverse events.Follow up was performed at 4, 12 and 24 weeks.The results of the study revealed a favourable BCTQ symptom score at 4 weeks in the ultrasound-guided group compared to the landmark-based group.Furthermore, a higher proportion of patients in the landmark-based group displayed adverse events compared to the ultrasound-guided group. Otherwise, there were... Read More »
Level 2 RCT
4%
Synopsis: 90 patients with chronic ankle instability were randomized to either 3 weeks of joint mobilization treatment, 3 weeks of sham mobilization treatment, or no intervention.Patients were assessed following the completion of one session, at the completion of the 3-week treatment phases, and at 6-month follow-up after the completion of treatment for range of motion in dorsiflexion, the Cumberland Ankle Instability Tool, and the Star Excursion Balance Test in the anterior, posteromedial, and posterolateral directions.Results significantly favoured the mobilization group compared to both sham and control groups after 3 weeks and at 6-month follow-up outcome for all measures. Additional, range of... Read More »
Level 2 RCT
4%
Synopsis: 61 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to treatment with either a single intraarticular injection of bone morrow-derived mesenchymal stem cells (BM-MSC) or oral acetaminophen 500mg every 8 hours for 6 months.Patients were assessed for outcome on a visual analog scale for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Patients were assessed 1 week, 1 month and 6 month follow-up. Results demonstrated significantly... Read More »
Level 2 RCT
4%
Synopsis: 652 male footballers from 2nd or 3rd tier Norwegian teams were randomized to receive or not receive the Copenhagen adductor strengthening program in addition to regular pre-season and regular season training.The primary outcome of interest was the prevalence of groin injury.The secondary outcome of interest was the prevalence of substantial groin injury.Intervention was performed during pre-season 2-3 times per week, and during the regular season once per week.Follow up was performed weekly for the duration of the 28 week season.The results from this study revealed significantly lower odds of groin injury in the adductor strengthening group compared to the control group. There was, however,... Read More »
Level 2 RCT
3%
Synopsis: 310 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to a single intraarticular injection of either extended release triamcinolone acetonide 16mg (FX006 16mg; Flexion Therapeutics), extended release triamcinolone acetonide 32mg (FX006 32mg; Flexion Therapeutics), or placebo saline.Patients were assessed for the primary outcome measure of pain on a Numeric Rating Scale weekly for 24 weeks, with the primary endpoint at 12 weeks.At the primary endpoint, neither the FX006 16mg group nor the FX006 32mg group demonstrated significantly lower pain scores compared to the placebo group.At secondary endpoints, significantly lower NRS score was noted with FX006 16mg vs placebo for weeks 1-9, and with FX006 32mg vs placebo from weeks 1-11 and week 13.Differences between groups at all subsequent timepoints were not significant. Read More »
Level 2 RCT
3%
Synopsis: 43 patients with a partial- or full-thickness rotator cuff tear were randomized to nonoperative treatment with either a suprascapular nerve block or subacromial injection.Patients were assessed for outcome on a modified Constant score at 2, 6, and 12 weeks after treatment. While no significant... Read More »
Level 2 RCT
3%
Synopsis: 30 patients with chronic ankle instability were randomized to either a session of Maitland grade III mobilizations or to no intervention.Patients were assessed pre- and post-test for ankle range of motion in dorsiflexion, outcome on the Star Excursion Balance Test, spinal reflex excitability of the fibularis longus and soleus muscles, and corticospinal excitability of the fibularis longus and soleus muscles. Results demonstrated a... Read More »
Level 2 RCT
3%
Synopsis: 171 elderly patients with knee osteoarthritis were randomized to receive home-based exercise therapy alongside health education, or health education only.The primary outcomes of interest were the WOMAC pain and stiffness scores.Secondary outcomes included the five times sit to stand test (FTSST), the timed up and go test, the 6-minute walking test (6MWT), and the arthritis impact measurement scales 2 - short form (AIMS2-SF) body, symptom, emotional, society and total scores.Follow up was performed 12 weeks after the initiation of treatment. The results of... Read More »
Level 2 RCT
2%
Synopsis: 90 patients scheduled for total knee arthroplasty were randomized to one of three nerve block combinations for postoperative analgesia: an obturator nerve block (ONB) plus continuous adductor canal block (cACB), a tibial nerve block (TNB) plus cACB, or an ONB and TNB plus cACB.Patients were assessed primarily for patient-controlled analgesia consumption, time to first analgesia request, and pain scores postoperatively. Results for morphine... Read More »
Level 1 RCT