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Synopsis: 442 patients suffering from unilateral knee pain were randomized to evaluate the safety and efficacy of 26 weeks of a single-injection of intra-articular non-animal stabilized hyaluronic acid (NASHA) compared to methylprednisolone acetate (MPA).Following 26 weeks of blinded evaluation, patients were offered a second injection with NASHA and were followed for an additional 26 weeks.The evidence presented in this study demonstrated that NASHA gel produced a non-inferior response rate in comparison to MPA.WOMAC pain, physical function, and stiffness evaluations favored NASHA over MPA during the blinded phase from 12 to 26 weeks.Sustained improvements were apparent in WOMAC outcomes irrespective of initial treatment in response to open-labeled extension with NASHA. No serious device-related... Read More »
Author verified Level 1 RCT
Synopsis: 60 patients with an isolated, full-thickness supraspinatus tear were randomized to either receive two postoperative ultrasound-guided injections of platelet-rich plasma or to no adjunct postoperative intervention.Patients were evaluated over a mean of 3.5 years for MRI (Sugaya classification) and clinical outcomes (QuickDASH, Oxford Shoulder Score, and Constant Score).At a mean of 3.5 years, there were no significant differences in clinical scores between groups, with the exception of a greater score on the abduction subscale of the Constant score in the PRP group. MRI outcomes were... Read More »
Level 2 RCT
Synopsis: 349 patients with knee osteoarthritis were randomized to either one intraarticular injection of Durolane hyaluronic acid followed by four weekly subcutaneous sham injections, or five weekly intraarticular injections of Artz hyaluronic acid.Patients were assessed for primarily for response on the Western Ontario and McMaster Universities Osteoarthritis Index to determine if Durolane was noninferior to Artz, as well as to compare the incidence of complications between groups.Analyses suggested that Durolane was noninferior to Artz for pain and functional improvement after 18 and 26 weeks. Incidence of treatment-related... Read More »
Level 2 RCT
Synopsis: 86 patients randomized to receive arthroscopic rotator cuff repair with acromioplasty (n=25/41 completed follow up) or without acromioplasty (n=31/45 completed follow up) were re-assessed from a multicentered, randomized controlled trial.Outcomes of interest included the Western Ontario Rotator Cuff score (WORC) and incidence of re-operation/revision.Mean follow up was 11 years post-operation. No significant differences... Read More »
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