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20%
14%
13%
12%
12%
11%
7%
4%
2%
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100%
7%
Synopsis: 120 patients with Kellgren-Lawrence grade II-IV knee osteoarthritis were randomized to intraarticular injection with either a combination of hyaluronic acid and corticosteroid, or hyaluronic acid alone.Patients were followed-up for 6 months posttreatment for outcome related to pain on a visual analog scale and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Between groups, bth VAS pain and WOMAC assessments significantly favoured the HA+CS group compared to the HA alone group at 1 week, 1 month, and 3 months; differences between groups at 6 months were not significant. However, when the... Read More »
Level 2 RCT
4%
Synopsis: 1583 patients with symptomatic knee osteoarthritis were randomized to either glucosamine monotherapy, chondroitin monotherapy, combined glucosamine and chondroitin therapy, celecoxib 200mg daily, or placebo.Patients were assessed over 24 weeks of treatment.In the primary analysis, only the celecoxib group demonstrated a significantly higher rate of patients attaining the primary efficacy endpoint - a reduction of WOMAC pain by a minimum of 20% relative to baseline - compared to placebo. However, when only... Read More »
RCT
3%
Synopsis: 234 patients with carpal tunnel syndrome were randomized to a single injection of 20mg methylprednisolone acetate or 6 weeks of nightly splinting.Patients were assessed primarily for outcome on the Boston Carpal Tunnel Questionnaire at 6 weeks and 6 months.In addition, cost-utility analysis was performed.Results for the BCTQ Symptom Severity Score and Functional Status Score significantly favoured the CS injection group compared to the nightly splinting group at 6 weeks, while differences at 6 months were not significant. On a 6-month... Read More »
Level 2 RCT
3%
Synopsis: 82 patients with symptomatic knee osteoarthritis were randomized to either treatment with a topical flaxseed oil preparation or to placebo.Patients were to apply allocated treatment three times daily for 6 weeks.The outcome measure was the Knee Injury and Osteoarthritis Outcome Score (KOOS). Improvement in each... Read More »
Level 2 RCT
2%
Synopsis: 21 patients with stage 1 or 2 adhesive capsulitis were randomized to corticosteroid injection therapy with or without the addition of a 3-month physiotherapy program after injection.Patients were followed for outcome on the Shoulder Pain and Disability Index primarily, as well as for range of motion, pain scores, and satisfaction.Follow-up was performed at 6 weeks, 12 weeks, and 26 weeks.Results demonstrated lower SPADI score at 6 weeks in the group which participated in PT after injection.In addition, range of motion was significantly higher in the PT group in forward flexion at 6 weeks, and in abduction and external rotation at 6 and 12 weeks. Differences between groups... Read More »
Level 2 RCT
2%
Synopsis: 19 randomized controlled trials were included in this network meta-analysis which sought to quantify the effects of various nonoperative modalities and control for treatment of chronic ankle instability.When compared to control, approaches which demonstrated a significant effect size on the star-excursion balance test when assessed post-treatment included balance training plus strength training, balance training plus mobilization, strength training alone, balance training alone, and manual therapy. In addition, combined... Read More »
Level 1 Meta Analysis
2%
Synopsis: 147 patients with a diagnosis of plantar fasciities were randomized to injection therapy with either 40mg of micronized dehydrated human amnion/chorion membrane (dHACM) in 1mL saline or to placebo saline alone.In addition to injection, all patients were managed with orthoses for 2 weeks after injection.Patients were assessed primarily for change in visual analog pain score (VAS pain) from baseline to 3 months post-injection. Results demonstrated a... Read More »
Level 2 RCT
2%
Synopsis: 18 randomized controlled trials were included in this meta-analysis which sought to evaluate the efficacy of cupping intervention for treatment of neck pain.Analyses were separated based on control group: inactive or active intervention.Compared to both inactive control intervention and active control interventions, there was low to very low strength evidence that cupping therapy significantly reduced pain and disability. In addition, when... Read More »
Level 1 Meta Analysis
1%
Synopsis: 18 patients with a displaced (>2mm) base of the 5th metatarsal fracture were randomized to be treated with either open reduction and internal fixation (ORIF) or nonoperative management with a short leg cast.The purpose of this study was to compare clinical measures of pain and function, time to union, and restoration of injured metatarsal length between groups.Follow-up was performed for an average of 8.5 weeks.Results demonstrated no significant differences in pain or functional scores, despite a significantly shorter time to union in the operative group. Read More »
Level 2 RCT
1%
Synopsis: 120 patients with full thickness rotator cuff tears were randomized to receive either 3 weeks of post-surgery immobilization in a sling, or 6 weeks of immobilization in a brace (with an abduction pillow placing the arm in a neutral position).Follow-up was performed at the 6 week time-point, as well as at 3, 6 and 12 months post-surgery.Outcomes reported included the Western Ontario Rotator Cuff (WORC) index, Constant Murley (CM) score, range of movement (ROM), as well as MRI results and patient-reported satisfaction.Sling immobilization for a period of 3 weeks was found to be a non-inferior treatment compared to brace immobilization for a period of 6 weeks, according to primary outcome of WORC index at 12 months. Additionally, patient reported... Read More »
Level 1 RCT