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You are viewing the most viewed ACE Reports by Primary Care Physicians over the last 30 days in all specialties.
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①
Synopsis:
This systematic review and meta-analysis included 16 randomized controlled trials (RCTs) with a total of 1,993 patients with knee osteoarthritis.The study compared the effects of platelet-rich plasma (PRP) injections versus various nonoperative treatments, including hyaluronic acid (HA), corticosteroids, and saline.Pooled outcomes of interest were patient-reported symptom relief, pain improvement, reintervention rates, and cartilage status assessed by MRI.The findings showed PRP had significantly better outcomes in symptom relief, reduced reintervention rates, and pain improvement compared to controls, but no significant benefit for cartilage regeneration. These findings suggest...
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Level 1 Meta Analysis
5%
①
Synopsis:
A total of 152 patients with symptomatic knee osteoarthritis were randomized to receive either a combination of Apocynin and Paeonol 800 mg (APPA; n=75) or placebo (n=77) twice daily for 28 days.The primary outcome of interest was the change in pain measured using the WOMAC pain subscale.Secondary outcomes included WOMAC function and stiffness, as well as other patient-reported outcomes such as daily pain intensity and global assessment scores.Outcomes were assessed at baseline and on day 28.Overall, the study found no significant improvement in the primary or secondary outcomes for APPA compared to placebo.However, a predefined subgroup analysis revealed significant pain reduction in participants with nociplastic/neuropathic features.APPA was well-tolerated, with mild to moderate gastrointestinal side effects being the most common. These findings suggest...
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Level 1 RCT
3%
①
Synopsis:
Five randomized controlled trials (189 patients) comparing platelet-rich plasma (PRP) against conservative treatment for chronic Achilles tendinopathy were included in this systematic review and meta-analysis.Outcomes of interest included the Victorian Insitute of Sport Assessment (VISA-A) score, pain during activity on a Visual Analog Scale (VAS), and Achilles tendon thickness.VISA-A scores at 6 weeks favored the PRP group.Tendon thickness also favored the PRP group. All other outcomes...
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Level 1 Meta Analysis
3%
①
Synopsis:
Six studies involving 517 patients with neck pain were included in this systematic review and meta-analysis, comparing cervical manipulations to thoracic or cervicothoracic manipulations.Pooled outcomes of interest included pain intensity, neck disability, and cervical range of motion.The analysis revealed no significant differences in pain reduction, disability improvement, or cervical range of motion between the intervention groups. Moderate to very...
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Level 1 Meta Analysis
3%
①
Synopsis:
Sixty-four patients with symptomatic erosive hand osteoarthritis were randomized to receive methotrexate (MTX) 10 mg weekly (n=32) or placebo (n=32).The primary outcome was the change in pain, measured via a visual analogue scale (VAS), from baseline to 3 months.Secondary outcomes included pain at 12 months, function, and structural progression assessed using the Verbruggen-Veys (VV) and Ghent University Scoring System (GUSS) radiographic scores, as well as MRI assessments.Outcomes were evaluated over 12 months.Overall, the study revealed no significant differences between MTX and placebo regarding pain reduction or functional improvement.However, structural progression was slower in the MTX group, with more erosive joints transitioning to remodeling (27% vs 15%, p=0.03). The findings suggest...
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Level 1 RCT
3%
①
Synopsis:
This systematic review and meta-analysis included 10 randomized controlled trials involving patients diagnosed with knee osteoarthritis.The study compared arthroscopic surgery to various conservative treatments such as physical therapy, pharmacologic interventions, and placebo.Pooled outcomes of interest included pain relief, functional recovery (WOMAC and SF-36), and patient satisfaction.Results showed no significant differences in pain relief, functional recovery, or patient satisfaction between arthroscopy and conservative treatments. The findings suggest...
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Level 1 Meta Analysis
3%
①
Synopsis:
One hundred patients with knee osteoarthritis undergoing primary total knee arthroplasty were randomized to receive either oral nefopam (40 mg twice daily) alongside celecoxib and pregabalin (n=50) or a placebo alongside the same regimen (n=50).The primary outcome was postoperative consumption of rescue analgesics (oxycodone and morphine).Secondary outcomes included pain scores (VAS) at rest and during motion, knee functional recovery (range of motion and ambulation distance), length of hospital stay, liver function indicators, and complication rates.Outcomes were assessed during hospitalization and within the first 48 hours postoperatively.Overall, the nefopam group showed statistically significant reductions in opioid consumption and pain scores, along with better functional recovery and shorter hospital stays.However, the magnitude of these improvements was not deemed clinically significant. These findings suggest...
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Level 1 RCT
3%
①
Synopsis:
One hundred nine patients with severe hip osteoarthritis were randomized to receive either total hip replacement (n=53) or supervised resistance training (n=56).The primary outcome of interest was the change in the Oxford Hip Score from baseline to six months, which evaluates pain and function.Secondary outcomes included various dimensions of quality of life, physical activity levels, and functional performance tests.Outcomes were assessed at baseline and six months.Overall, total hip replacement demonstrated significantly greater improvements in hip pain and function compared to resistance training. The findings suggest...
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Level 1 RCT
3%
Synopsis:
Seventy-five patients with primary knee osteoarthritis (Kellgren Lawrence grades II-IV) were randomized to receive corticosteroid injections (80 mg Kenalog) with either no bupivacaine (n=25), 2 ml of 0.25% bupivacaine (n=25), or 4 ml of 0.25% bupivacaine (n=25).The primary outcome of interest was pain reduction, measured using the Visual Analog Scale (VAS) at several time points.Outcomes were assessed immediately before and after the injection, at 2 minutes, 1 day, 2 weeks, 6 weeks, and 12 weeks post-injection.Overall, the results of the study revealed no significant differences in VAS pain scores among the groups at any time point (p > .05), with all groups achieving the greatest pain relief at 1 day post-injection. These findings suggest...
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Conference Report
1%
②
Synopsis:
36 patients with ankle sprains were randomized to receive a treatment using an elastic compression stocking or a standard treatment with Tubigrip tubular bandage.The primary outcome measure was the difference in health-related quality of life (QoL) between the two groups. Results indicated that...
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Author verified Level 2 RCT