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You are viewing the most viewed ACE Reports by Primary Care Physicians over the last 30 days in all specialties.
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11%
①
Synopsis:
One hundred twenty-eight patients with knee osteoarthritis were randomized to receive prolotherapy with 5% dextrose (n=30), 10% dextrose (n=30), 20% dextrose (n=30), or exercise plus hotpack only (n=30).All prolotherapy groups received three injection sessions at weeks 0, 3, and 6, combined with a home exercise program and hotpack therapy.The primary outcome was pain assessed by VAS.Secondary outcomes included WOMAC scores, knee range of motion, timed up and go (TUG) test, and SF-36 quality of life scores.Outcomes were measured at baseline, 6 weeks, and 12 weeks.Overall, results showed that 10% and 20% dextrose groups had significantly greater pain reduction and functional improvements compared with exercise alone, while 20% dextrose also improved knee flexion. The findings suggest...
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Level 1 RCT
5%
②
Synopsis:
144 patients with primary complete Achilles tendon rupture were randomized to be treated with either a surgical repair and accelerated functional rehabilitation or with only the accelerated functional rehabilitation. Over the course of a two year follow up, it was observed that Achilles tendon rupture led to clinically similar results between the two treatment groups.
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Level 2 RCT
5%
②
Synopsis:
186 patients with a severe lateral ankle sprain (type III) were randomized to treatment to 3 weeks of rigid immobilization with a walking boot followed by 3 weeks of immobilization with a functional brace, or to a functional brace for 6 weeks.The purpose was to compare these two conservative treatment methods for outcomes in pain, function, and ankle stability up to 12 weeks after the injury.AOFAS scores were better for the first 6 weeks in patients receiving the functional brace, and pain and comfort outcomes also benefited within the first few weeks from using a functional brace. By 12 weeks,...
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Author verified Level 2 RCT
5%
①
Synopsis:
13 studies with a total of 3647 men were included in this meta-analysis to analyze the effect of eight drugs (alfacalcidol, alendronate, ibandronate, risedronate, zoledronate, strontium ranelate, teriparatide, and parathyroid hormone) on bone mass density (BMD) in the lumbar spine (LS) and fracture incidence in males with osteoporosis. Network meta-analysis based on direct and indirect comparisons demonstrated that zoledronate had the greatest efficacy in increasing BMD in LS when compared to placebo, and teriparatide had the greatest efficacy in reducing fracture rate when compared to placebo.
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Level 1 Meta Analysis
5%
②
Synopsis:
76 patients with Dupuytren's contracture and a palpable nodule were randomized to one of four groups; 0.25mg collagenase clostridium histolyticum (CCH) injection, 0.40mg CCH injection, 0.60mg CCH injection, or placebo injection.Patients were assessed over 8-week follow-up nodule size and hardness, pain, patient satisfaction, and investigator-rated improvement.After 8 weeks, reduction in nodule size was significantly greater in the 0.40mg and 0.60mg CCH groups compared to placebo, and reduction in nodule hardness was significantly greater in the 0.25mg, 0.40mg, and 0.60mg CCH groups compared to placebo. Composite responder rate...
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Level 2 RCT
5%
Synopsis:
30 blinded randomized controlled trials evaluating the use of hyaluronic acid injections in comparison to a placebo injection in patients with knee osteoarthritis were included in this systematic review and meta-analysis.The objective of this systematic review and meta-analysis was to compare the efficacy and safety of hyaluronic acid injections across different dosing regimens.At 3 months, data were available for 2-4 injection and 5+ injection groups.The 2-4 injection groups demonstrated significantly lower pain scores compared placebo (SMD -0.76 p<0.00001), while the 5+ injection groups did not demonstrate significantly lower pain compared to placebo (SMD -0.20; p=0.09).At 6 months, both the 2-4 injection group (SMD -0.36; p=0.008) and 5+ injection group demonstrated significantly lower pain compared to placebo (SMD -0.18; p=0.04).The single injection groups did not significantly reduce pain compared to placebo at 6 months (SMD -0.04; p=0.67).When looking at the incidence of adverse events, only the 5+ injection group demonstrated a significantly greater incidence compared to placebo (RR 1.67; p=0.02).
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Meta Analysis
5%
①
Synopsis:
10 randomized controlled trials (555 patients) that compared the effect of exercise on bone mineral density (BMD) in middle-aged and older men against a control were included in this meta-analysis.Outcomes of interest included changes in lumbar spine BMD, femoral neck BMD, total hip BMD, and trochanter BMD. All outcomes favored...
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Level 1 Meta Analysis
5%
①
Synopsis:
Sixty male patients with unilateral ACL rupture undergoing autologous hamstring tendon reconstruction were randomized to receive either Nordic hamstring exercises with standard rehabilitation (n=30) or conventional rehabilitation alone (n=30).The primary outcome was muscle strength recovery measured by peak torque, total work, and average peak torque at 60°/s and 120°/s.Secondary outcomes included thigh circumference, Lysholm Knee Score, and knee stability tests (Lachman, anterior drawer, KT-1000).Outcomes were assessed preoperatively, and at 12 and 24 weeks postoperatively.Overall, the study showed that the Nordic hamstring group had significantly greater improvements in thigh circumference (p<0.001), hamstring strength (p<0.05 across multiple measures), and Lysholm Knee Score (97.4±3.0 vs 88.9±7.9, p=0.041). The findings suggest...
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Level 1 RCT
5%
Perioperative Blood Flow Restriction Therapy Program After Anterior Cruciate Ligament Reconstruction
①
Synopsis:
Forty-six patients who sustained an anterior cruciate ligament (ACL) tear and were scheduled for reconstruction were randomized into a group receiving either a blood flow restriction (BFR) therapy program (n=22) or a control group without BFR (n=24).The primary outcome of interest was isometric quadriceps strength at 3 months postoperatively, measured as peak and mean torques during seated leg extension exercises and presented as a ratio of the healthy limb.Secondary outcomes included patient-reported outcomes such as pain, knee function, and physical function, knee range of motion, quadriceps circumference and adverse effects.Outcomes were assessed up to 6 months postoperatively. Overall, the study...
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Level 1 RCT
5%
①
Synopsis:
This systematic review and meta-analysis included 14 randomized controlled trials involving 698 patients with low back pain.The studies compared the effects of respiratory exercises to routine lower back pain treatments.Pooled outcomes of interest included pain intensity and physical disability.The results showed that respiratory exercises significantly reduced pain intensity (p < .00001) and improved physical disability (p < .00001). The main findings...
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Level 1 Meta Analysis