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Synopsis: Four randomized controlled trials, 1 double-arm comparative study, and 4 single-arm prospective studies were included in this investigation into the efficacy of hyaluronic acid (HA) injections for ankle osteoarthritis.A total of 354 patients were included throughout the studies.Pooled effect sizes indicated a significantly beneficial effect of HA compared to pre-treatment condition.Comparative analysis of HA against reference treatment tended to favour HA injection, although statistical significance was not exhibited. Furthermore, comparison to... Read More »
Author verified Level 1 Meta Analysis
Synopsis: 72 patients scheduled to receive primary unilateral cemented total knee arthroplasty (TKA) were randomly assigned into one of two groups to determine if the simultaneous application of tranexamic acid and indirect factor Xa inhibitor was a safe and effective blood loss prevention treatment when compared to indirect factor Xa inhibitor alone.Patients either received tranexamic acid in combination with indirect factor Xa inhibitor, or a placebo in combination with indirect factor Xa inhibitor, and were followed-up for 90 days after surgery. The results of... Read More »
Level 1 RCT
Synopsis: 34 randomized controlled trials (2,594 patients) were used in this meta-analysis analyzing the safety and efficacy of tranexamic acid (TXA) in patients undergoing primary total knee arthroplasty (TKA). Pooled results demonstrated intravenous (IV) and intraarticular (IA) use of TXA significantly reduced total blood loss, postoperative blood loss, hemoglobin (Hb) loss, and blood transfusion without increasing the risk of deep vein thrombosis (DVT) or other adverse effects. Read More »
Level 1 Meta Analysis
Synopsis: 44 patients with isolated rib fractures were randomized to receive either a lidocaine pain relief skin patch or a placebo vehicle patch.The purpose of this study was to determine whether the Lidopat® 5% skin patch was effective in treating traumatic rib fracture pain. The results displayed... Read More »
Level 2 RCT
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