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You are viewing the most viewed ACE Reports by Primary Care Physicians over the last 30 days in all specialties.
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②
Synopsis:
Nine studies (6 randomized controlled trials and 3 prospective comparative studies) were selected to examine the effects of leukocyte-poor platelet rich plasma and leukocyte-rich platelet rich plasma in knee osteoarthritis treatment.Due to the presence of only one direct comparison between LP-PRP and LR-PRP at the time of the study, studies which compared either to hyaluronic or placebo were included, and network meta-analysis was undertaken.Primary outcome was the incidence of local adverse events, while secondary efficacy outcomes included the change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores and International Knee Documentation Committee (IKDC) scores.Incidence of local adverse events was higher with LP-PRP or LR-PRP compared to HA or placebo, and both were ranked at approximately 20% of being the best treatment for the outcome.Nevertheless, the difference between LP-PRP and LR-PRP for incidence of local adverse events was not significant. LP-PRP was ranked...
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Author verified Level 2 Meta Analysis
20%
Synopsis:
Seventy patients with rotator cuff tears were randomized to receive either hyaluronic acid injection (n=35) or placebo (n=35) after arthroscopic rotator cuff repair.The primary outcome of interest was tendon integrity assessed by MRI using the Sugaya classification.Secondary outcomes included VAS pain scores, ASES, CONSTANT scores, range of motion, and strength.Outcomes were assessed at 2 weeks, 3 months, 6 months, and 12 months.Overall, the results of the study revealed that hyaluronic acid did not improve pain or functional scores compared with placebo but was associated with greater recovery of abduction, internal rotation, and external rotation at 6 and 12 months, and a lower re-tear rate on MRI (14.4% vs 26.7%). The findings suggest...
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Conference Report
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①
Synopsis:
Sixty athletes with MRI-confirmed grade 2 hamstring injuries were randomized to receive ultrasound-guided Platelet-Rich Plasma (PRP) injections plus standard therapy (n=30) or standard therapy alone (n=30).The primary outcome of interest was time to return to play.Secondary outcomes included MRI healing at 21 days, re-injury rates, and adverse events, with follow-up extending to 24 months.Overall, the results of the study revealed that PRP significantly accelerated return to play, improved MRI healing at 21 days, and trended toward lower re-injury rates.No adverse events occurred. These findings suggest...
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Level 1 RCT
10%
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Synopsis:
Six randomized controlled trials were included in this meta-analysis which compared the effects of romosozumab to placebo, teriparatide, and alendronate in postmenopausal osteoporosis treatment.The change in bone mineral density at the lumbar spine, total hip, and femoral neck significantly favoured romosozumab versus both placebo and active controls. Fracture rates after...
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Level 2 Meta Analysis
10%
①
Synopsis:
One hundred thirty-two patients with Kellgren-Lawrence grade 1-3 knee osteoarthritis were randomized to receive three weekly intra-articular injections of either LR-PRP (n=66) or LP-PRP (n=66).The primary outcome was the change in the International Knee Documentation Committee (IKDC) subjective score at 12 months.Secondary outcomes included pain, function, and quality of life assessed through various scales (KOOS, WOMAC, VAS, EQ-5D, Tegner activity scale), as well as objective measures such as range of motion and quadriceps circumference.Outcomes were evaluated at baseline and at 2, 6, and 12 months.Overall, both groups showed significant improvement in subjective and objective outcomes, with no significant differences except for a transient greater improvement in IKDC at 2 months in the LR-PRP group, and minor differences in ROM and quadriceps circumference at specific time points.No severe adverse events were reported, and the rate of treatment failure was similar. The study concluded...
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Level 1 RCT
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Synopsis:
One hundred ninety-six patients undergoing aseptic or septic revision total hip arthroplasty were randomized to receive either closed incision negative-pressure therapy (ciNPT) (n=105) or a silver-impregnated dressing (n=91).The primary outcome of interest was the rate of wound complications.Secondary outcomes included type of wound complications, need for reoperation due to wound issues, and comparison of perioperative variables.Outcomes were assessed at 90 days postoperatively.Overall, the results of the study revealed no significant difference in wound complication rates between the ciNPT and control groups (11.7% vs.12.9%, p=0.95), nor in reoperations for wound-related issues (3.9% vs.1.1%, p=0.37). These findings suggest...
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Conference Report
10%
①
Synopsis:
One hundred fifty-two patients with non-specific chronic low back pain (CLBP) were randomized to receive individualized cognitive functional therapy (CFT)(n=76) or a sham intervention (neutral talking plus detuned low-level laser; n=76).The primary outcomes were pain intensity (0–10) and Oswestry Disability Index (0–100) at 6 weeks.Secondary outcomes included pain and disability at 3 and 6 months, functioning, pain self-efficacy, global perceived effect, and analgesic use.Outcomes were assessed pre-treatment, post-treatment (6 weeks), and at 3 and 6 months.Overall, the results revealed clinically meaningful, statistically significant advantages for CFT over sham at 6 weeks that persisted through 6 months. In short, CFT...
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Level 1 RCT
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