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You are viewing the most viewed ACE Reports by Primary Care Physicians over the last 30 days in all specialties.
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①
Synopsis:
Eight randomized controlled trials including 434 patients with isolated meniscal tears treated via arthroscopic meniscectomy were included in this systematic review and meta-analysis comparing home-based rehabilitation (HBP) versus supervised inpatient and/or outpatient physical therapy (IOP).Pooled outcomes of interest included the Lysholm score, subjective IKDC score, knee flexion and extension, thigh girth, hop test performance, and return-to-work time.Short-term results showed that IOP was associated with slightly better Lysholm scores and vertical hop performance, while HBP showed better thigh girth outcomes.However, midterm results showed no significant differences in primary or secondary outcomes between groups. These findings suggest...
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Level 1 Meta Analysis
4%
①
Synopsis:
Two hundred forty patients with chronic midportion Achilles tendinopathy were randomized to receive either a single platelet-rich plasma (PRP) injection (n=121) or a sham subcutaneous dry needle injection (n=119).The primary outcome was the VISA-A score at 6 months, which assesses pain, function, and activity limitations related to Achilles tendinopathy.Secondary outcomes included the VISA-A score at 3 months, pain via visual analog scale (VAS), and health-related quality of life using EQ-5D-5L at multiple follow-up points (2 weeks, 3 months, and 6 months).Overall, the results of the study revealed no significant difference between the PRP and sham groups in any of the measured outcomes, including the primary VISA-A score at 6 months. These findings suggest...
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Level 1 RCT
4%
①
Synopsis:
One hundred five patients with clinically diagnosed knee osteoarthritis were randomized to receive a 6-week internet-based exercise and education program (n=48) or routine self-management care (n=57).The primary outcome of interest was change in self-reported knee pain using a numerical rating scale at 6 weeks.Secondary outcomes included physical function tests (30-second sit-to-stand, Timed Up-and-Go), WOMAC subscales (pain, stiffness, physical function), muscle strength, and quantitative sensory testing.Outcomes were assessed at baseline and 6 weeks.Overall, the results of the study revealed a significantly greater improvement in pain, function, and hamstring strength in the internet-based intervention group compared to usual care. These findings suggest...
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Level 1 RCT
4%
①
Synopsis:
Five randomized controlled trials (189 patients) comparing platelet-rich plasma (PRP) against conservative treatment for chronic Achilles tendinopathy were included in this systematic review and meta-analysis.Outcomes of interest included the Victorian Insitute of Sport Assessment (VISA-A) score, pain during activity on a Visual Analog Scale (VAS), and Achilles tendon thickness.VISA-A scores at 6 weeks favored the PRP group.Tendon thickness also favored the PRP group. All other outcomes...
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Level 1 Meta Analysis
2%
①
Synopsis:
Four randomized controlled trials were selected for inclusion in this meta-analysis which compared results in hip osteoarthritis treatment between platelet-rich plasma injections and hyaluronic acid injections.Data on patient-reported pain and function scores were pooled at 2, 6 and 12 months post-injection. The only significant...
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Level 1 Meta Analysis
2%
②
Synopsis:
41 patients including 48 knees with Kellgren-Lawrence grade II-III osteoarthritis were randomized to intraarticular injection therapy with either platelet-rich plasma or corticosteroid (methylprednisolone acetate 40mg).Patients were assessed for outcome on the Knee Injury and Osteoarthritis Outcome Score (KOOS), pain on a visual analog scale, performance on a 20-metre walk test, knee range of motion in flexion, and flexion contracture after 2 and 6 months following injection.Findings demonstrated significantly favourable results in the PRP group compared to the CS group for changes in four out of five KOOS scales, VAS pain scores, and 20-metre walk test times. Knee range of...
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Level 2 RCT
2%
①
Synopsis:
192 patients with knee osteoarthritis were randomized to three weekly intraarticular injections with either platelet-rich plasma or hyaluronic acid.The focuse of the current study was outcome after 2 and 5 years following treatment.Results for clinical outcome on the International Knee Documentation Committee (IKDC) subjective score, the EuroQoL 5-dimensions (EQ-5D) and the Tegner activity scale demonstrated no significant differences between the PRP group and HA group at 2 or 5 years.Within the first 2 years of treatment, rate of reintervention, including either repeat injection therapy or surgery, was significantly lower in the PRP group compared to the HA group. However, at 5...
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Level 1 RCT
2%
①
Synopsis:
1054 patients being treated for bone or joint infection at 26 UK centers were randomized in this non-inferiority trial to receive 6 weeks of oral antibiotic therapy (n=527) or 6 weeks of intravenous antibiotic therapy (n=527).The primary outcome of interest was the rate of definite treatment failure.Secondary outcomes of interest included the rate of treatment discontinuation, catheter complications, diarrhea caused by C.difficile, serious adverse events, length of hospitalization, and patient-reported outcomes (Oxford Hip and Knee Scores [OHS; OKS]; EuroQual-5Dimension scores [EQ-5D]).Outcomes were assessed at 6 weeks, 4 months, and 1 year follow-up.Oral antibiotics were found to be non-inferior to intravenous antibiotics with regards to the risk of definitive treatment failure.The incidence of early discontinuation of treatment and catheter complications, and length of hospitalization were significantly higher in the intravenous group, however, no differences in the incidence of diarrhea or serious adverse events were observed between the two groups. EQ-5D scores and...
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Level 1 RCT
2%
Synopsis:
99 patients with a partial-thickness rotator cuff tear or rotator cuff tendinopathy were randomized to injection therapy with either a platelet rich plasma injection or corticosteroid injection.Patients were assessed for outcome on a visual analog scale for pain, the Western Ontario Rotator Cuff Index, the American Shoulder and Elbow Surgeons (ASES) score, and incidence of patients who progressed to operative treatment. Results demonstrated significantly...
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Conference Report
2%
①
Synopsis:
Patients with mild to moderate knee osteoarthritis face a range of treatment options, without any clear evidence on which options are most effective.Among injectable therapies, platelet-rich plasma is a relatively new option which has had mixed evidence to date.Some previous studies have compared PRP to hyaluronic acid (HA), but with differing numbers of injections in each group.In this study, the authors performed a meta-analysis of studies which provided PRP and HA injections in a 1:1 ratio. They found that...
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Level 1 Meta Analysis