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Synopsis: Sixteen randomized controlled studies containing a total of 3084 patients were included in this meta-analysis including patients with displaced femoral neck fractures undergoing total hip arthroplasty (THA; n=1521) or hemiarthroplasty (HA; n=1563).Pooled outcomes of interest included the following: incidence of revision, functional outcomes (evaluated using the Harris hip score), incidence of mortality, health-related quality of life (QoL; evaluated using the EuroQol-5 Dimensions [EQ-5D] Index), incidence of periprosthetic fracture, incidence of dislocation, and operative time.Subgroup analyses was conducted by level of risk of bias.Revision surgery, incidence of mortality and dislocation were all analyzed at 12-60 months follow-up, where as the rest of the outcomes were assessed at 12-36 months.Pooled results revealed that health-related quality of life, evaluated using EQ-5D Index, was statistically significantly in favour of the THA group vs.HA (p=0.001).However, pooled operative time was statistically significantly shorter in the HA group vs THA (p=0.001). All other pooled... Read More »
Author verified Level 1 Meta Analysis
4%
Synopsis: 12,211 patients from 21 trauma centers in the United States and Canada were included in this non-inferiority randomized trial comparing aspirin (n=6,101) and low molecular-weight heparin (n=6110).The primary outcome of interest was death by any cause at 90 days.Secondary outcomes of interest included the risk of thromboembolic events (pulmonary embolism; deep-vein thrombosis), cause-specific death, bleeding & wound complications, and the rate of infection.Aspirin was found to be non-inferior to low molecular-weight heparin with respect to the primary outcome of death by any cause. No differences in... Read More »
Level 1 RCT
4%
Synopsis: One hundred five patients with clinically diagnosed knee osteoarthritis were randomized to receive a 6-week internet-based exercise and education program (n=48) or routine self-management care (n=57).The primary outcome of interest was change in self-reported knee pain using a numerical rating scale at 6 weeks.Secondary outcomes included physical function tests (30-second sit-to-stand, Timed Up-and-Go), WOMAC subscales (pain, stiffness, physical function), muscle strength, and quantitative sensory testing.Outcomes were assessed at baseline and 6 weeks.Overall, the results of the study revealed a significantly greater improvement in pain, function, and hamstring strength in the internet-based intervention group compared to usual care. These findings suggest... Read More »
Level 1 RCT
4%
Synopsis: One hundred forty-two patients with full-thickness small to large rotator cuff tears were randomized to receive either abduction brace immobilization (n=65) or sling immobilization (n=66) for 6 weeks following arthroscopic rotator cuff repair.The primary outcome was the Pittsburgh Sleep Quality Index (PSQI) at 6 weeks postoperatively.Secondary outcomes included anxiety (Self-rating Anxiety Scale), pain levels, patient satisfaction, functional scores (ASES), and tendon healing assessed via ultrasonography at 6 weeks and 1 year. Overall, the results of the study revealed that at 6 weeks, the sling group had significantly better sleep quality, less anxiety, less pain, and higher satisfaction compared to the brace group.However, no differences were found in any outcomes at 1 year, including tendon healing. These findings suggest... Read More »
Level 1 RCT
3%
Synopsis: 80 patients with distal radius fractures were randomized to receive either a 4-week (n=40) or a 6-week immobilization program.The primary outcome of interest was Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) scores at one year.Secondary outcomes of interest included QuickDASH scores at 3 and 6 months, incidence of adverse events, and range of motion in radial and ulnar deviation, dorsiflexion, and palmar flexion.All outcomes were comparable between the two groups at all time points. Therefore, a shorter... Read More »
Level 1 RCT
3%
Synopsis: One hundred and nineteen patients with insertional Achilles tendinopathy were randomized to received extracorporeal shockwave therapy with eccentric exercise (ESWT +EE) (n=58) or eccentric exercise (EE) and sham therapy (n=61).The primary outcome was function measured by the Victorian Institute of Sports Assessment-Achilles questionnaire (VISA-A).Secondary outcomes of interest included pain scores, the Foot and Ankle Outcome Score (FAOS), the Short Form Health Survey (SF-12), recurrence and failure of treatment.Both groups demonstrated significant improvements from baseline.No differences in the VISA-A, FAOS or SF-12 were found at any time point between groups. The EWST+EE group... Read More »
Level 1 RCT
3%
Synopsis: 58 elderly patients undergoing hip arthroplasty under spinal anesthesia were randomized to receive either 5 mg oral midodrine (n=29) or a placebo (n=29).The primary outcome of interest was intraoperative ephedrine consumption.Secondary outcomes included the incidence of post-spinal hypotension, bradycardia, hypertension, mean arterial pressure (MAP), and heart rate (HR).Outcomes were assessed throughout the duration of the surgery.Overall, the results of the study revealed that the midodrine group had significantly lower intraoperative ephedrine consumption and a reduced incidence of hypotension compared to the control group. The findings suggest... Read More »
Level 1 RCT
3%
Synopsis: 12 randomized controlled trials (788 patients) comparing the use of a minimally invasive medial midvastus approach (MMV-TKA) versus the standard medial parapatellar total knee arthroplasty (MP-TKA) were included in this systematic review and meta-analysis.Outcomes of interest included the Knee Society Score (KSS), knee pain on a Visual Analog Scale (VAS), knee function on a Normalized Function Scale, knee range of motion (ROM), time to straight leg activity, incidence of loose outboard support belt use, operative time, length of stay, blood loss, and incidence of postoperative complications.KSS scores, VAS pain scores, and knee joint flexural activity at 3 months, and days of straight leg raises were significantly better in the MMV-TKA group.Operative time was significantly shorter in the MP-TKA group. All other outcomes... Read More »
Level 1 Meta Analysis
3%
Synopsis: Forty patients aged age 18 to 25 years old with a first episode of anterior shoulder dislocation were randomized to receive arthroscopic Bankart repair (n=20) or nonoperative management (n=20). The primary outcome of interest was recurrence of instability at two year follow-up.Secondary outcomes of interest included range of motion, return to sport, Disabilities of the Arm, Shoulder and Hand (DASH) score, the Walch-Duplay score, and the Western Ontario Shoulder Instability Index (WOSI).At two year follow-up, recurrence of instability was significantly lower in the group undergoing arthroscopic Bankart repair.The Walch-Duplay score and WOSI scores were significantly better in the surgical group.Patients had a higher return to sport in the surgical group at two years follow-up. No surgical complications... Read More »
Author verified Level 1 RCT
3%
Synopsis: 84 patients over 18 years of age with isolated rib fractures were included in this single center, prospective, placebo controlled, double blind trial.Patients were randomly allocated to receive either 10% lidocaine spray (LS; n=29), etofenamate spray (ES; n=28) or placebo spray (PS; n=27).The primary outcome of interest was pain intensity measured using a numerical rating scale (NRS) at baseline, and 15, 30, 60 and 120 minutes.Other outcomes of interest included rescue medication requirements and adverse events.Study findings suggest that all three groups demonstrated similar NRS scores, with no significant difference in pain reduction found at any timepoint.The maximum reduction was seen in the LS group between baseline and 120 minutes, however this difference was not statistically significant.It was also seen that the need for rescue medication was lowest in the LS group; a difference that was found to be clinically significant but not statistically significant. Importantly, only one... Read More »
Author verified Level 1 RCT