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Efficacy and Safety of Platelet-Rich Plasma with Hyaluronic Acid vs Platelet-Rich Plasma for Knee OA
March 2025
Efficacy and Safety of Platelet-Rich Plasma with Hyaluronic Acid vs Platelet-Rich Plasma for Knee OA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA).
J Orthop Surg Res. 2025 Jan 17;20(1):57.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Eleven randomized controlled trials (RCTs) including 1023 patients with knee osteoarthritis (KOA) were analyzed in this systematic review and meta-analysis to compare PRP + HA combination therapy versus PRP monotherapy. The pooled outcomes assessed included changes in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total scores, Visual Analogue Scale (VAS) scores, Lequesne i...
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