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Musculoskeletal Evidence
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Osteoarthritis
Comparison of three therapeutic methods of transcutaneous electrical nerve stimulation, embedding acupuncture, and drug therapy on interleukin-6 and pain levels in patients with knee osteoarthritis.
Clin Rheumatol. 2026 01-Jun;():. 10.1007/s10067-026-08197-6
Comparison of three therapeutic methods of transcutaneous electrical nerve stimulation, embedding acupuncture, and drug therapy on interleukin-6 and pain levels in patients with knee osteoarthritis.
Clin Rheumatol. 2026 01-Jun;():. 10.1007/s10067-026-08197-6
Osteoarthritis
Adipose-Derived Cell Therapies Versus Nonactive Controls for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Am J Phys Med Rehabil. 2026 01-Jun;():. 10.1097/PHM.0000000000002908
Adipose-Derived Cell Therapies Versus Nonactive Controls for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
Am J Phys Med Rehabil. 2026 01-Jun;():. 10.1097/PHM.0000000000002908
Osteoarthritis
Collagen protein supplementation does not modulate biomarkers of bone metabolism following total hip arthroplasty: a randomized, double-blind, placebo-controlled trial.
Clin Nutr ESPEN. 2026 01-Jun;():. 10.1016/j.clnesp.2026.103253
Collagen protein supplementation does not modulate biomarkers of bone metabolism following total hip arthroplasty: a randomized, double-blind, placebo-controlled trial.
Clin Nutr ESPEN. 2026 01-Jun;():. 10.1016/j.clnesp.2026.103253
Osteoarthritis
Dose-response effects of transcutaneous electrical nerve stimulation for knee osteoarthritis: A systematic review and meta-analysis.
Osteoarthr Cartil Open. 2026 01-Jun;():. 10.1016/j.ocarto.2026.100765
Dose-response effects of transcutaneous electrical nerve stimulation for knee osteoarthritis: A systematic review and meta-analysis.
Osteoarthr Cartil Open. 2026 01-Jun;():. 10.1016/j.ocarto.2026.100765
Osteoarthritis
Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials.
Front Med (Lausanne). 2026 01-Jun;():. 10.3389/fmed.2026.1799943
Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials.
Front Med (Lausanne). 2026 01-Jun;():. 10.3389/fmed.2026.1799943
Osteoarthritis
6-week cryo-compression therapy and opioid use after unicompartmental knee arthroplasty with comparable pain scores: a secondary analysis of a randomized controlled trial.
Acta Orthop. 2026 01-Jun;():. 10.2340/17453674.2026.45963
6-week cryo-compression therapy and opioid use after unicompartmental knee arthroplasty with comparable pain scores: a secondary analysis of a randomized controlled trial.
Acta Orthop. 2026 01-Jun;():. 10.2340/17453674.2026.45963
Osteoarthritis
Efficacy of non-pharmacological interventions for knee osteoarthritis in the elderly: A systematic review and meta-analysis.
Medicine (Baltimore). 2026 01-Jun;():. 10.1097/MD.0000000000048984
Efficacy of non-pharmacological interventions for knee osteoarthritis in the elderly: A systematic review and meta-analysis.
Medicine (Baltimore). 2026 01-Jun;():. 10.1097/MD.0000000000048984
Osteoarthritis
Autologous platelet-rich plasma versus hyaluronic acid, corticosteroids or saline for knee osteoarthritis: can blood draw volume serve as a proxy for platelet dose? A systematic review and meta-analysis.
Int Orthop. 2026 01-May;():. 10.1007/s00264-026-06782-7
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
Autologous platelet-rich plasma versus hyaluronic acid, corticosteroids or saline for knee osteoarthritis: can blood draw volume serve as a proxy for platelet dose? A systematic review and meta-analysis.
Int Orthop. 2026 01-May;():. 10.1007/s00264-026-06782-7
Osteoarthritis
Randomized clinical trial comparing intra-articular injection of bone marrow aspirate clot and bone marrow aspirate concentrate in grade 3 and 4 knee osteoarthritis.
Stem Cell Res Ther. 2026 01-Apr;():. 10.1186/s13287-026-05041-1
Randomized clinical trial comparing intra-articular injection of bone marrow aspirate clot and bone marrow aspirate concentrate in grade 3 and 4 knee osteoarthritis.
Stem Cell Res Ther. 2026 01-Apr;():. 10.1186/s13287-026-05041-1
Osteoarthritis
The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study.
Front Pain Res (Lausanne). 2026 01-Apr;():. 10.3389/fpain.2026.1789088
The effect of a topical curcumin formulation (VAS-101) on knee pain in adults with knee osteoarthritis: a randomised, double-blind, placebo-controlled study.
Front Pain Res (Lausanne). 2026 01-Apr;():. 10.3389/fpain.2026.1789088
Osteoarthritis
Efficacy and safety of genicular nerve ablation techniques for knee osteoarthritis: a systematic review and meta-analysis of sham-controlled randomized trials.
Pain Med. 2026 01-Apr;():. 10.1093/pm/pnaf140
Efficacy and safety of genicular nerve ablation techniques for knee osteoarthritis: a systematic review and meta-analysis of sham-controlled randomized trials.
Pain Med. 2026 01-Apr;():. 10.1093/pm/pnaf140
Osteoarthritis
Metformin for knee osteoarthritis in overweight and obese adults: a systematic review and meta-analysis of efficacy, safety, and disease-modifying anti-inflammatory potential.
Inflammopharmacology. 2026 01-Apr;():. 10.1007/s10787-026-02218-1
Metformin for knee osteoarthritis in overweight and obese adults: a systematic review and meta-analysis of efficacy, safety, and disease-modifying anti-inflammatory potential.
Inflammopharmacology. 2026 01-Apr;():. 10.1007/s10787-026-02218-1
Osteoarthritis
PRP Plasma Gel vs Hyaluronic Acid vs Corticosteroid for Knee Osteoarthritis
PRP Plasma Gel vs Hyaluronic Acid vs Corticosteroid for Knee Osteoarthritis
Osteoarthritis
Comparative efficacy of Tai Chi versus balance training on functional performance and postural control during sit and stand transitions in individuals with knee osteoarthritis: A randomized trial.
J Sci Med Sport. 2026 01-Mar;():. 10.1016/j.jsams.2025.10.003
Comparative efficacy of Tai Chi versus balance training on functional performance and postural control during sit and stand transitions in individuals with knee osteoarthritis: A randomized trial.
J Sci Med Sport. 2026 01-Mar;():. 10.1016/j.jsams.2025.10.003
General Orthopaedics
Anterior Cruciate Ligament Reconstruction Does Not Reduce Osteoarthritis Risk but Lowers Total Knee Arthroplasty Rates Compared With Conservative Treatment
Anterior Cruciate Ligament Reconstruction Does Not Reduce Osteoarthritis Risk but Lowers Total Knee Arthroplasty Rates Compared With Conservative Treatment
Osteoarthritis
Combining ACL Reconstruction with Lateral Extra-Articular Tenodesis Reduces Long-Term Osteoarthritis Risk Versus Isolated ACL Reconstruction: A Systematic Review and Meta-Analysis.
J Bone Joint Surg Am. 2026 01-Feb;():. 10.2106/JBJS.25.00907
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
Combining ACL Reconstruction with Lateral Extra-Articular Tenodesis Reduces Long-Term Osteoarthritis Risk Versus Isolated ACL Reconstruction: A Systematic Review and Meta-Analysis.
J Bone Joint Surg Am. 2026 01-Feb;():. 10.2106/JBJS.25.00907
Osteoarthritis
The efficacy of metformin for pain, function, and quality of life in knee osteoarthritis: A systematic review and meta-analysis.
Semin Arthritis Rheum. 2026 01-Apr;():. 10.1016/j.semarthrit.2025.152908
This study has been identified as potentially high impact.
OE's AI-driven High Impact metric estimates the influence a paper is likely to have by integrating signals from both the journal in which it is published and the scientific content of the article itself.
Developed using state-of-the-art natural language processing, the OE High Impact model more accurately predicts a study's future citation performance than journal impact factor alone.
This enables earlier recognition of clinically meaningful research and helps readers focus on articles most likely to shape future practice.
The efficacy of metformin for pain, function, and quality of life in knee osteoarthritis: A systematic review and meta-analysis.
Semin Arthritis Rheum. 2026 01-Apr;():. 10.1016/j.semarthrit.2025.152908
Osteoarthritis
Improvement in postural imbalance with intake of resveratrol (polyphenolic phytoalexin) in patients of knee osteoarthritis.
Explore (NY). 2026 01-Feb;():. 10.1016/j.explore.2026.103341
Improvement in postural imbalance with intake of resveratrol (polyphenolic phytoalexin) in patients of knee osteoarthritis.
Explore (NY). 2026 01-Feb;():. 10.1016/j.explore.2026.103341
Osteoarthritis
Impact of home-based exercise and clinic-based physiotherapy on mobility status of patients undergoing total knee replacement: A randomized clinical trial.
J Bodyw Mov Ther. 2025 01-Dec;():. 10.1016/j.jbmt.2025.09.006
Impact of home-based exercise and clinic-based physiotherapy on mobility status of patients undergoing total knee replacement: A randomized clinical trial.
J Bodyw Mov Ther. 2025 01-Dec;():. 10.1016/j.jbmt.2025.09.006
Osteoarthritis
Effectiveness of genicular nerve block on pain and disability in chronic knee osteoarthritis: a randomized double blinded placebo controlled trial.
Clin Rheumatol. 2026 01-Feb;():. 10.1007/s10067-025-07818-w
Effectiveness of genicular nerve block on pain and disability in chronic knee osteoarthritis: a randomized double blinded placebo controlled trial.
Clin Rheumatol. 2026 01-Feb;():. 10.1007/s10067-025-07818-w
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