IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective

J Arthroplasty. 2017 Jan;32(1):37-42

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

Nonoperative treatment versus suspensory device fixation for type III-IV AC joint dislocations

J Bone Joint Surg Am. 2018 Nov 21;100(22):1912-1918. doi: 10.2106/JBJS.18.00412

AAOS 2016: IV + oral acetaminophen comparable for pain and narcotic use following TJA

OTA 2013: Open reduction and internal fixation compared to primary subtalar fusion

OTA 2019: IV Ibuprofen Reduces Opioid Consumption in Trauma Patients

Perioperative ibuprofen & acetaminophen vs. ibuprofen alone for analgesia in arthroplasty

Pain Physician. 2016 Jul;19(6):349-56

Combined IV & topical TXA reduces blood loss and transfusion rate in THA

J Bone Joint Surg Am. 2016 Jun 15;98(12):983-91

Intraarticular levobupivacaine plus IV dexketoprofen for post-knee arthroscopy analgesia

Knee Surg Sports Traumatol Arthrosc. 2015 Dec;23(12):3516-22

AAOS 2015: Combined IV and local TXA administration efficacious in TKA

AAOS2019: Similar outcomes with oral and IV TXA for blood loss in thoracolumbar spinal fusion

IV and topical TXA superior to placebo for hematological outcomes after PLIF

World Neurosurg. 2019 Feb;122:e821-e827.

Syndesmotic screw fixation vs. no fixation in supination-external rotation ankle fractures

Foot Ankle Int. 2014 Oct;35(10):988-95.

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Similar 2-yr clinical scores between hydrogel implant & OAT for Outerbridge III-IV cartilage lesions

Knee Surg Sports Traumatol Arthrosc. 2018 Oct;26(10):2934-2941. doi: 10.1007/s00167-018-4834-5

Preemptive analgesia comparable to standard protocol for pain after pediatric osteotomy

Paediatr Anaesth. 2016 Apr;26(4):438-43.

AAOS: IV tranexamic acid & aminocaproic acid on reducing blood loss in orthopaedic surgery