IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective

J Arthroplasty. 2017 Jan;32(1):37-42

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

OTA 2013: Open reduction and internal fixation compared to primary subtalar fusion

Intraarticular levobupivacaine plus IV dexketoprofen for post-knee arthroscopy analgesia

Knee Surg Sports Traumatol Arthrosc. 2015 Dec;23(12):3516-22

AAOS 2016: IV + oral acetaminophen comparable for pain and narcotic use following TJA

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

Perioperative ibuprofen & acetaminophen vs. ibuprofen alone for analgesia in arthroplasty

Pain Physician. 2016 Jul;19(6):349-56

Combined IV & topical TXA reduces blood loss and transfusion rate in THA

J Bone Joint Surg Am. 2016 Jun 15;98(12):983-91

Syndesmotic screw fixation vs. no fixation in supination-external rotation ankle fractures

Foot Ankle Int. 2014 Oct;35(10):988-95.

AAOS 2015: Combined IV and local TXA administration efficacious in TKA

AAOS2018: IV-TXA reduces blood loss, not transfusion rate, in reverse total shoulder arthroplasty

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

AAOS: IV tranexamic acid & aminocaproic acid on reducing blood loss in orthopaedic surgery

Epidural ropivacaine vs. IV PCA for postoperative pain after lumbar interbody fusion

Eur Spine J. 2016 May;25(5):1601-7.

Combined IV-topical TXA versus IV TXA alone in patients undergoing revision THA

J Arthroplasty. 2016 Nov;31(11):2548-2553

Preemptive analgesia comparable to standard protocol for pain after pediatric osteotomy

Paediatr Anaesth. 2016 Apr;26(4):438-43.

Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion

BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9

Adjuvant IV or epidural dexamethasone in lower limb surgeries among pediatric patients

Pain Physician. 2016 Jul;19(6):E841-52.

AAOS2017: Similar Hb drop and transfusion rate between oral and IV TXA in THA