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Reduced opioid consumption, improved pain and function with IV parecoxib plus oral celecoxib in TKA
February 2020
Reduced opioid consumption, improved pain and function with IV parecoxib plus oral celecoxib in TKA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Postoperative intravenous parecoxib sodium followed by oral celecoxib post total knee arthroplasty in osteoarthritis patients (PIPFORCE): a multicentre, double-blind, randomised, placebo-controlled trial
BMJ Open. 2020 Jan 9;10(1):e030501.Synopsis
Two hundred and forty-six patients with knee osteoarthritis and scheduled for an elective unilateral total knee arthroplasty were randomized to receive post-operative treatment with sequential intravenous parecoxib and oral celecoxib, or placebo. The primary outcome of interest was cumulative opioid consumption. Secondary outcomes of interest included the Knee Society Score (KSS), the Western Onta...
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