Increased IV-TXA Dosage Reduces Blood Loss, Improves Pain and Clinical Outcomes in TKA Patients

How to Cite

OrthoEvidence. Increased IV-TXA Dosage Reduces Blood Loss, Improves Pain and Clinical Outcomes in TKA Patients. ACE Report. 2020;9(10):3. Available from: https://myorthoevidene.com/AceReport/Report/12369

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Additional benefits of multiple-dose tranexamic acid to anti-fibrinolysis and anti-inflammation in total knee arthroplasty: a randomized controlled trial.

Arch Orthop Trauma Surg. 2020 Aug;140(8):1087-1095

Contributing Authors: Y Lei J Xie Q Huang W Huang F Pei

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Synopsis

Two hundred and two patients with osteoarthrosis or rheumatoid arthritis undergoing a unilateral total knee arthroplasty were randomized to receive either one of the following interventions: 4 doses of Intravenous (IV) Tranexamic acid (TXA), 5 doses of IV-TXA, or 6 doses of IV-TXA or control (no TXA). The primary outcome of interest was hidden blood loss. Additional outcomes measured included the ...