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Increased IV-TXA Dosage Reduces Blood Loss, Improves Pain and Clinical Outcomes in TKA Patients
October 2020
Increased IV-TXA Dosage Reduces Blood Loss, Improves Pain and Clinical Outcomes in TKA Patients
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Additional benefits of multiple-dose tranexamic acid to anti-fibrinolysis and anti-inflammation in total knee arthroplasty: a randomized controlled trial.
Arch Orthop Trauma Surg. 2020 Aug;140(8):1087-1095Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Two hundred and two patients with osteoarthrosis or rheumatoid arthritis undergoing a unilateral total knee arthroplasty were randomized to receive either one of the following interventions: 4 doses of Intravenous (IV) Tranexamic acid (TXA), 5 doses of IV-TXA, or 6 doses of IV-TXA or control (no TXA). The primary outcome of interest was hidden blood loss. Additional outcomes measured included the ...
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