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IV and Intra-Articular TXA vs. Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty

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Ace Report Cover
May 2023

IV and Intra-Articular TXA vs. Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty

Vol: 303| Issue: 5| Number:3| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Combination of Intravenous and Intra-Articular Application of Tranexamic Acid and Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.

Orthop Surg. 2023 Mar;15(3): 687-694.

Contributing Authors:
C Zheng J Ma J Xu H Si Y Liu M Li B Shen

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Synopsis

181 patients with end-stage knee osteoarthritis scheduled to receive a total knee arthroplasty were randomized to receive intravenous and intra-articular tranexamic acid (n=90) or epsilon-aminocaproic acid (n=91). The primary outcomes of interest were total blood loss, transfusion rate, and hemoglobin drop. Secondary outcomes of interest included postoperative length of stay and complications. The...

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