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IV and Intra-Articular TXA vs. Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty
May 2023
IV and Intra-Articular TXA vs. Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Combination of Intravenous and Intra-Articular Application of Tranexamic Acid and Epsilon-Aminocaproic Acid in Primary Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.
Orthop Surg. 2023 Mar;15(3): 687-694.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
181 patients with end-stage knee osteoarthritis scheduled to receive a total knee arthroplasty were randomized to receive intravenous and intra-articular tranexamic acid (n=90) or epsilon-aminocaproic acid (n=91). The primary outcomes of interest were total blood loss, transfusion rate, and hemoglobin drop. Secondary outcomes of interest included postoperative length of stay and complications. The...
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