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Biochemical and clinical outcomes between IV vs. topical tranexamic acid for blood loss in TKA
January 2020
Biochemical and clinical outcomes between IV vs. topical tranexamic acid for blood loss in TKA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels
J Bone Joint Surg Am. 2019 Sep 20.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
66 patients were randomized to receive topical tranexamic acid (TXA) or intravenous (IV) TXA for the reduction of blood loss in total knee arthroplasty (TKA). The primary outcome of interest was the systemic and wound levels of plasma-anti-plasmin (PAP). Additional outcomes of interest included systemic and wound levels of prothrombin fragment 1.2 (PF1.2), interleukin (IL)-6 and TXA, total blood l...
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