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Oral ibandronic acid inferior to IV zoledronic acid for metastatic breast cancer to bone

Lancet Oncol. 2014 Jan;15(1):114-22. doi: 10.1016/S1470-2045(13)70539-4.

RCT Tumour Breast Metastasis Roche Ibandronic Acid Intravenous Zoledronic Acid IV Oral - Hide

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Zoledronic acid given upfront maintains BMD in postmenopausal breast cancer patients

Cancer. 2012 Mar 1;118(5):1192-201. doi: 10.1002/cncr.26313. Epub 2011 Oct 10

RCT Tumour Breast Postmenopausal Women Novartis Letrozole Delayed Zoledronic Acid Intravenously - Hide

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Reduction in Odds of Pathological Fracture with Denosumab vs Zoledronic Acid for Bone Metastases

J Am Acad Orthop Surg Glob Res Rev. 2020 Aug-01;():. 10.5435/JAAOSGlobal-D-20-00045

Meta-analysis Tumour Bone Fracture Denosumab Bisphosphonate Zoledronic Acid Cancer Humanized monoclonal antibody - Hide

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Eicosapentaenoic and docosahexaenoic acid supplementation in breast cancer patients

Nutr Cancer. 2014;66(1):68-76. doi: 10.1080/01635581.2014.847964. Epub 2013 Nov 25

RCT Metabolic Disorders Breast Postmenopausal Women Docosahexaenoic Acid Eicosapentaenoic Acid Placebo - Hide

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Early vs standard zoledronic acid treatments for prostate cancer metastatic to bone

J Clin Oncol. 2014 Apr 10;32(11):1143-50. doi: 10.1200/JCO.2013.51.6500.

RCT Tumour Metastasis Algeta Amgen Aventis Bayer EXINI Diagnostics Novartis Sanofi Zoledronic Acid - Hide

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Aerobic-resistance exercise versus home-based exercise for BMD in female cancer survivors

Breast Cancer Res Treat. 2016 Feb;155(3):491-500

RCT Physical Therapy & Rehab Women Tamoxifen Aerobic Home-Based Exercise Resistance Exercise - Hide

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Prostate cancer: Zoledronic acid as an adjuvant therapy is well-tolerated and improves BMD

Prostate Cancer Prostatic Dis. 2013 Dec;16(4):382-6. doi: 10.1038/pcan.2013.35. Epub 2013 Oct 1

RCT Metabolic Disorders Osteoporosis Fracture Calcium Supplements Vitamin Zoledronic Acid - Hide

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The effect of adjuvant aromatase inhibitors on BMD in women with breast cancer

Lancet Oncol. 2014 Apr;15(4):474-82. doi: 10.1016/S1470-2045(14)70035-X. Epub 2014 Mar 11

RCT Tumour Breast Postmenopausal Women Pfizer Anastrozole Exemestane - Hide

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Resistance & impact training has effect on lumbar bone mass and bone degradation markers

Breast Cancer Res Treat. 2011 Jun;127(2):447-56. doi: 10.1007/s10549-011-1444-z. Epub 2011 Mar 19

RCT General Orthopaedics Breast Postmenopausal Women Spine Lumbar Exercises Impact Stretching Training - Hide

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Balloon kyphoplasty more effective than non-surgical treatment in cancer patients with VCF

Lancet Oncol. 2011 Mar;12(3):225-35. doi: 10.1016/S1470-2045(11)70008-0. Epub 2011 Feb 16

RCT Tumour Metastasis Joint Vertebral Fracture Pain Medtronic Balloon Kyphoplasty Compression Standard Non-Surgical - Hide

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Electro-acupuncture reduces arthralgia in cancer patients taking aromatase inhibitors

Eur J Cancer. 2014 Jan;50(2):267-76. doi: 10.1016/j.ejca.2013.09.022. Epub 2013 Oct 24

RCT Tumour Breast Metastasis Women Pain Electro-Acupuncture Inhibitor - Hide

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Dronabinol improves chronic non-cancer pain when added to standard opioid therapy

J Pain. 2008 Mar;9(3):254-64

RCT Cannabis Pain Solvay Opioid - Hide

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Minimal Access Surgery Reduces Blood Loss vs Open Surgery for Metastatic Spinal Cord Compression

Anticancer Res. 2020 Oct-01;():.

RCT Spine Axial Skeleton Decompression Open Surgery Spinal cord injury and/or disease Surgical Strategy Cancer Spinal Cord Minimal Access Surgery - Hide

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Tibolone reduces fracture risk in osteoporotic women but increases stroke risk

N Engl J Med. 2008 Aug 14;359(7):697-708

RCT Metabolic Disorders Osteoporosis Postmenopausal Stroke Women Fracture Organon Tibolone Placebo - Hide

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Denosumab noninferior to zoledronic acid in the treatment of bone metastasis

J Clin Oncol. 2011 Mar 20;29(9):1125-32. doi: 10.1200/JCO.2010.31.3304. Epub 2011 Feb 22

RCT Tumour Breast Lesion Metastasis Myeloma Amgen Novartis Infusion Placebo Subcutaneous Injections Of Denosumab Zoledronic Acid - Hide

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Hematopoietic stem cell transplantation: Improved QOL with physical exercise programs

Phys Ther. 2013 Apr;93(4):514-28. doi: 10.2522/ptj.20120181. Epub 2012 Dec 6.

Meta-analysis Physical Therapy & Rehab Bone Marrow Control Physical Exercise Program Physical Therapy Physiotherapy Psychological Training Transplantation - Hide

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Significant reduction in 6-year fragility fracture risk with zoledronate vs placebo for osteopenia

N Engl J Med. 2018 Dec 20;379(25):2407-2416. doi: 10.1056/NEJMoa1808082

RCT Metabolic Disorders Elderly Osteopenia Postmenopausal Women Lower Extremity Hip Bone Femur Neck Fracture Novartis Zoledronate Intravenous Infusion Placebo - Hide

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Recombinant human bone morphogenetic protein-7 ineffective in spinal fusion vs. control

Global Spine J. 2016 Mar;6(2):124-32

Meta-analysis Spine Axial Skeleton Bone Morphogenetic Protein Control ICBG Iliac Crest Bone Graft Local Bone Recombinant Revision Spinal Fusion Spine Fusion TCP - Hide

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Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake

Am J Clin Nutr. 2014 Dec;100(6):1578-86.

RCT Metabolic Disorders Elderly Osteoporosis Fracture Vitamin B-12 Acid Placebo - Hide

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Long-term mortality unchanged by liberal blood transfusions in older hip surgery patients

Lancet. 2014 Dec 9. pii: S0140-6736(14)62286-8.

RCT General Orthopaedics Lower Extremity Hip Fracture Blood Transfusions Restrictive Blood Transfusion - Hide

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Oral ibandronic acid inferior to IV zoledronic acid for metastatic breast cancer to bone

Zoledronic acid given upfront maintains BMD in postmenopausal breast cancer patients

Reduction in Odds of Pathological Fracture with Denosumab vs Zoledronic Acid for Bone Metastases

Eicosapentaenoic and docosahexaenoic acid supplementation in breast cancer patients

Early vs standard zoledronic acid treatments for prostate cancer metastatic to bone

Aerobic-resistance exercise versus home-based exercise for BMD in female cancer survivors

Prostate cancer: Zoledronic acid as an adjuvant therapy is well-tolerated and improves BMD

The effect of adjuvant aromatase inhibitors on BMD in women with breast cancer

Resistance & impact training has effect on lumbar bone mass and bone degradation markers

Balloon kyphoplasty more effective than non-surgical treatment in cancer patients with VCF

Electro-acupuncture reduces arthralgia in cancer patients taking aromatase inhibitors

Dronabinol improves chronic non-cancer pain when added to standard opioid therapy

Minimal Access Surgery Reduces Blood Loss vs Open Surgery for Metastatic Spinal Cord Compression

Tibolone reduces fracture risk in osteoporotic women but increases stroke risk

Denosumab noninferior to zoledronic acid in the treatment of bone metastasis

Hematopoietic stem cell transplantation: Improved QOL with physical exercise programs

Significant reduction in 6-year fragility fracture risk with zoledronate vs placebo for osteopenia

Recombinant human bone morphogenetic protein-7 ineffective in spinal fusion vs. control

Osteoporotic fracture rate not significantly improved by vitamin B-12 or folic acid intake

Long-term mortality unchanged by liberal blood transfusions in older hip surgery patients

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Emerging Treatments

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