Palonosetron vs. Granisetron for Chemotherapy-Induced Nausea and Vomiting in Pediatric Osteosacroma

How to Cite

OrthoEvidence. Palonosetron vs. Granisetron for Chemotherapy-Induced Nausea and Vomiting in Pediatric Osteosacroma. ACE Report. 2022;255(3):27. Available from: https://myorthoevidence.com/AceReport/Report/14645

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Does a single dose of palonosetron have any role in preventing acute chemotherapy-induced nausea and vomiting in pediatric osteosarcoma patients without dexamethasone? A randomized clinical trial

Adv Clin Exp Med. 2022 01-Mar;():. 10.17219/acem/142332

Contributing Authors:
Z Li C Li P Li Y Li J Lai S Rastogi

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Synopsis

200 pediatric osteosarcoma patients were randomized to receive a single intravenous dose of palonosetron or granisetron for antiemetic prophylaxis. The primary outcome was patient response to treatment in the first 24 hours after chemotherapy (complete response; partial response; failure). Adverse events were also recorded. Results found that patients who received palonosetron had a significantly ...