Ifosfamide-based chemotherapy yields high survival rate for treatment of osteosarcoma

Study Type:Meta analysis

OE Level Evidence:1

Journal Level of Evidence:N/A

Efficacy and safety of ifosfamide-based chemotherapy for osteosarcoma: a meta-analysis

Drug Des Devel Ther. 2015 Nov 4;9:5925-32

Contributing Authors: XL Fan GP Cai LL Zhu GM Ding

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Synopsis

7 randomized controlled trials with 2,529 patients with histologically confirmed osteosarcoma were included in this meta-analysis. The purpose of this study was to compare the safety and efficacy of ifosfamide-based chemotherapy to a control group receiving chemotherapy without ifosfamide. The results displayed that ifosfamide-based chemotherapy had significantly higher event-free survival, overal...