Sixty patients with shoulder impingement syndrome were randomized to receive a dual-target (long head of bicep tendon and subacromial bursa) subacromial corticosteroid injection or a standard subacromial corticosteroid injection for the relief of pain and improvement of functional outcomes. The primary outcomes of interest were the Shoulder Pain and Disability Index (SPADI) pain, function and total scores. Secondary outcomes of interest included pain at rest, during the night, and during overhead activities. Follow up was performed at 1 and 3 months post-injection. Results found no significant differences in the improvement of all outcomes from baseline at 1 month post-injection between the two groups. However, the improvement from baseline in all outcomes at 3 months post-injection was significantly greater in the dual-target group compared to the standard group.