The effect of adjuvant aromatase inhibitors on BMD in women with breast cancer

How to Cite

OrthoEvidence. The effect of adjuvant aromatase inhibitors on BMD in women with breast cancer. ACE Report. 2020;9(8):14. Available from: https://myorthoevidene.com/AceReport/Report/6307

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Effects of adjuvant exemestane versus anastrozole on bone mineral density for women with early breast cancer (MA.27B): a companion analysis of a randomised controlled trial

Lancet Oncol. 2014 Apr;15(4):474-82. doi: 10.1016/S1470-2045(14)70035-X. Epub 2014 Mar 11

Contributing Authors: PE Goss DL Hershman AM Cheung JN Ingle S Khosla V Stearns H Chalchal K Rowland HB Muss HM Linden J Scher KI Pritchard CR Elliott T Badovinac-Crnjevic J St Louis JA Chapman LE Shepherd

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Synopsis

Four hundred and ninety-seven postmenopausal women with hormone-receptor-positive breast cancer were randomized to receive adjuvant exemestane 25 mg or anastrozole 1 mg daily for 5 years. Two subgroups were identified: those with baseline T-scores of -2.0 or greater at the spine and hip (subgroup 1), and those with baseline T-scores less than -2.0 at the spine and hip and taking bisphosphonates (s...