Early vs standard zoledronic acid treatments for prostate cancer metastatic to bone

How to Cite

OrthoEvidence. Early vs standard zoledronic acid treatments for prostate cancer metastatic to bone. ACE Report. 2020;9(8):15. Available from: https://myorthoevidence.com/AceReport/Report/6335

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Randomized Controlled Trial of Early Zoledronic Acid in Men With Castration-Sensitive Prostate Cancer and Bone Metastases: Results of CALGB 90202 (Alliance)

J Clin Oncol. 2014 Apr 10;32(11):1143-50. doi: 10.1200/JCO.2013.51.6500.

Contributing Authors: MR Smith S Halabi CJ Ryan A Hussain N Vogelzang W Stadler RJ Hauke JP Monk P Saylor N Bhoopalam F Saad B Sanford WK Kelly M Morris EJ Small

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Synopsis

Six hundred and forty-five patients with castration-resistant prostate cancer and bone metastases were randomized to either early administration of zoledronic acid or standard administration of zoledronic acid initiated following progression to castration-sensitive disease. The purpose was to determine whether early treatment would reduce time to developing a skeletal-related event (SREs) compared...