To unlock this feature and to subscribe to our weekly evidence emails, please create a FREE orthoEvidence account.


Already Have an Account?

Visit our Evidence-Based Covid-19 Website and Stay Up to Date with the latest Research.
Vol:270 Issue:1 Number:1 ISSN#:2564-2537
ACE Report #14815
Ace Report Cover General Orthopaedics

Comparative Benefits and Harms of Individual Opioids for Chronic Non-cancer Pain

How to Cite

OrthoEvidence. Comparative Benefits and Harms of Individual Opioids for Chronic Non-cancer Pain. ACE Report. 2022;270(1):1. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Comparative benefits and harms of individual opioids for chronic non-cancer pain: a systematic review and network meta-analysis of randomised trials

Br J Anaesth. 2022 Jul 8;S0007-0912(22)00288-4.

Contributing Authors:
J Busse Noori Atefeh Sadeghirad Behnam Wang Li Siemieniuk Reed A C Shokoohi Mostafa Kum Elena Jeddi Mark Montoya Luis Hong Patrick J Zhou Edward Couban Rachel J Juurlink David N Thabane Lehana Bhandari Mohit Guyatt Gordon H Busse Jason W

Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here


82 randomized controlled trials including 22,619 patients with chronic non-cancer pain were included in this network meta-analysis investigating the relative benefits and harms of individual opioids in both extended-release (ER) and immediate-release (IR) formulations. Outcomes of interest included pain relief, function, and gastrointestinal adverse events (vomiting; constipation; nausea). Results...

Ace Report Preview Image
CME Image

Continuing Medical Education Credits

You could be earning 0.5 CME credits for each report you read.

For Reprints and Permissions, click here

Please Login or Join to leave comments.