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Vol:270 Issue:1 Number:1 ISSN#:2564-2537
Meta-Analysis
ACE Report #14815
Ace Report Cover General Orthopaedics

Comparative Benefits and Harms of Individual Opioids for Chronic Non-cancer Pain


How to Cite

OrthoEvidence. Comparative Benefits and Harms of Individual Opioids for Chronic Non-cancer Pain. ACE Report. 2022;270(1):1. Available from: https://myorthoevidence.com/AceReport/Report/14815

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Comparative benefits and harms of individual opioids for chronic non-cancer pain: a systematic review and network meta-analysis of randomised trials

Br J Anaesth. 2022 Jul 8;S0007-0912(22)00288-4.

Contributing Authors:
J Busse Noori Atefeh Sadeghirad Behnam Wang Li Siemieniuk Reed A C Shokoohi Mostafa Kum Elena Jeddi Mark Montoya Luis Hong Patrick J Zhou Edward Couban Rachel J Juurlink David N Thabane Lehana Bhandari Mohit Guyatt Gordon H Busse Jason W

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Synopsis

82 randomized controlled trials including 22,619 patients with chronic non-cancer pain were included in this network meta-analysis investigating the relative benefits and harms of individual opioids in both extended-release (ER) and immediate-release (IR) formulations. Outcomes of interest included pain relief, function, and gastrointestinal adverse events (vomiting; constipation; nausea). Results...

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