Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

Similar efficacy with EACA and TXA for reduction of blood loss in patients undergoing TKA

J Orthop Traumatol. 2019 Jul 18;20(1):28.

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

TXA efficacy in perioperative spinal surgery bleeding

Spine J. 2015 Apr 1;15(4):752-761.

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

Int J Surg. 2019 May;65:45-51.

Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

BMC Musculoskelet Disord. 2013 Dec 5;14:340. doi: 10.1186/1471-2474-14-340

IV and topical TXA superior to placebo for hematological outcomes after PLIF

World Neurosurg. 2019 Feb;122:e821-e827.

TXA Reduces Blood Loss in Surgeries for Fractures of the Pelvis, Acetabulum and Proximal Femur

J Orthop Trauma. 2019 Aug;33(8):371-376.

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

AAOS 2016: TXA reduces total blood loss in extra-capsular hip fractures

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

AAOS2019: Similar outcomes with oral and IV TXA for blood loss in thoracolumbar spinal fusion

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction

Low-dose tranexamic acid does not reduce blood loss or transfusion rate in spinal surgery

J Neurosurg Anesthesiol. 2011 Oct;23(4):290-6. doi: 10.1097/ANA.0b013e31822914a1

AAOS 2015: Combined IV and local TXA administration efficacious in TKA

Intravenous, intraarticular irrigation, and drain administration of TXA in TKA

J Arthroplasty. 2014 Aug;29(8):1521-4