Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

TXA efficacy in perioperative spinal surgery bleeding

Spine J. 2015 Apr 1;15(4):752-761.

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

AAOS 2016: TXA reduces total blood loss in extra-capsular hip fractures

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25

Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

BMC Musculoskelet Disord. 2013 Dec 5;14:340. doi: 10.1186/1471-2474-14-340

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

TXA is effective and safe for reducing blood loss and transfusion in TKA patients

Eur J Orthop Surg Traumatol. 2015 Apr;25(3):525-41

Low-dose tranexamic acid does not reduce blood loss or transfusion rate in spinal surgery

J Neurosurg Anesthesiol. 2011 Oct;23(4):290-6. doi: 10.1097/ANA.0b013e31822914a1

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

EFORT: Intra-articular TXA reduces total blood loss in patients undergoing TKA

AAOS2017: Similar efficacy between IA TXA and IV TXA in total knee arthroplasty

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

Combined Topical & IV TXA superior to topical TXA alone for reducing blood loss in TKA

J Arthroplasty. 2015 May;30(5):776-80

AAOS 2015: Combined IV and local TXA administration efficacious in TKA

Intravenous, intraarticular irrigation, and drain administration of TXA in TKA

J Arthroplasty. 2014 Aug;29(8):1521-4