Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

Similar efficacy with EACA and TXA for reduction of blood loss in patients undergoing TKA

J Orthop Traumatol. 2019 Jul 18;20(1):28.

TXA efficacy in perioperative spinal surgery bleeding

Spine J. 2015 Apr 1;15(4):752-761.

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

IV and topical TXA superior to placebo for hematological outcomes after PLIF

World Neurosurg. 2019 Feb;122:e821-e827.

Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

BMC Musculoskelet Disord. 2013 Dec 5;14:340. doi: 10.1186/1471-2474-14-340

Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

Int J Surg. 2019 May;65:45-51.

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Low-dose tranexamic acid does not reduce blood loss or transfusion rate in spinal surgery

J Neurosurg Anesthesiol. 2011 Oct;23(4):290-6. doi: 10.1097/ANA.0b013e31822914a1

AAOS2019: Similar outcomes with oral and IV TXA for blood loss in thoracolumbar spinal fusion

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

TXA is effective and safe for reducing blood loss and transfusion in TKA patients

Eur J Orthop Surg Traumatol. 2015 Apr;25(3):525-41

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

TXA effective in reducing blood loss and transfusion in TKA vs. routine hemostasis

Arch Orthop Trauma Surg. 2015 Jul;135(7):1017-25

AAOS2017: Similar Hb drop and transfusion rate between oral and IV TXA in THA

TXA Reduces Blood Loss in Surgeries for Fractures of the Pelvis, Acetabulum and Proximal Femur

J Orthop Trauma. 2019 Aug;33(8):371-376.

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

AAOS 2016: TXA reduces total blood loss in extra-capsular hip fractures

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41