Local TXA Reduces Blood Loss vs Intravenous TXA in Patients Undergoing Total Hip Replacement

How to Cite

OrthoEvidence. Local TXA Reduces Blood Loss vs Intravenous TXA in Patients Undergoing Total Hip Replacement . ACE Report. 2020;9(12):4. Available from: https://myorthoevidene.com/AceReport/Report/12649

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

Better Treatment Values in Local Application of Tranexamic Acid (TXA) than Intravenous Application with the Same Dose in Total Hip Arthroplasty.

Adv Ther. 2020 Oct;37(10):4346-4355.

Contributing Authors: X Zhang L Wen J Pan D Ma

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Synopsis

Seventy-two patients scheduled for a primary, unilateral total hip replacement were randomized to receive a local administration of tranexamic acid (TXA) or intravenous administration of TXA at the same dosage. Outcomes of interest included the following: total blood loss, hidden blood loss, incidence of blood transfusion, hematocrit (Hct) and hemoglobin (Hb) levels, C-reactive protein (CRP) and i...