Oral acetaminophen demonstrates similar analgesic efficacy to IV acetaminophen in TKA and THA

Am J Health Syst Pharm. 2018 Mar 15;75(6):367-375

ISAKOS 2015: Platelet-Rich Plasma favourable compared to acetaminophen for primary knee OA

AAOS 2016: IV + oral acetaminophen comparable for pain and narcotic use following TJA

Acetaminophen is a suitable treatment for moderate osteoarthritis pain of the knee

Osteoarthritis Cartilage. 2009 Jan;17(1):1-7. Epub 2008 Jul 21

AAOS2018: Ibuprofen/acetaminophen equal to hydrocodone/acetaminophen for post-hand surgery analgesia

Immediate- vs extended-release tramadol HCL/acetaminophen for pain following TKA

Curr Med Res Opin. 2015 Jan;31(1):75-84.

AAOS 2016: Similar rates of nonunion with acetaminophen/NSAIDs in humeral shaft fractures

Perioperative ibuprofen & acetaminophen vs. ibuprofen alone for analgesia in arthroplasty

Pain Physician. 2016 Jul;19(6):349-56

IV Titrated Morphine vs Hydrocodone/Acetaminophen for pain relief of lower extremity fractures in ED

Exp Ther Med. 2018 Oct;16(4):3674-3679.

Diclofenac versus acetaminophen versus placebo for treatment of symptomatic knee osteoarthritis

Arch Intern Med. 2003 Jan 27;163(2):169-78

NSAIDs versus acetaminophen for treatment of knee and hip osteoarthritis

Osteoarthritis Cartilage. 2011 Aug;19(8):921-9

Efficacy of acetaminophen - with and without tramadol - for analgesia in extremity fracture fixation

J Bone Joint Surg Am. 2017 Nov 15;99(22):1908-1915

Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

J Arthroplasty. 2017 Oct;32(10):3029-3033

Morphine vs. mutlimodal acetaminophen/oxycodone for analgesia in painful acute fracture

Eur J Orthop Surg Traumatol. 2014 Oct;24(7):1305-9

Preemptive/preventive acetaminophen reduces pain in lower extremity surgery

J Clin Anesth. 2013 May;25(3):188-92. doi: 10.1016/j.jclinane.2012.09.004. Epub 2013 Apr 6

TKA: Dual-opioid treatment reduces pain and adverse GI events vs. oxycodone/acetaminophen

Clin Ther. 2013 Apr;35(4):498-511. doi: 10.1016/j.clinthera.2013.03.002

Lower pain and need for opioids with IV acetaminophen vs. placebo after total hip arthroplasty

J Arthroplasty. 2019 Jun;34(6):1155-1161. doi: 10.1016/j.arth.2019.02.033

Celecoxib versus acetaminophen for pain & MRI scores in chronic non-specific LBP

Arthritis Care Res (Hoboken). 2016 Jun;68(6):845-52

The role of acetaminophen and ibuprofen for pain relief in children undergoing pin removal

J Bone Joint Surg Am. 2014 Apr 2;96(7):597-602. doi: 10.2106/JBJS.M.00806.

Influences of route of acetaminophen administration and periarticular liposomal bupivacaine in TKA

J Arthroplasty. 2018 Jul;33(7S):S136-S141. doi: 10.1016/j.arth.2018.02.088