Oral acetaminophen demonstrates similar analgesic efficacy to IV acetaminophen in TKA and THA

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AAOS2018: Ibuprofen/acetaminophen equal to hydrocodone/acetaminophen for post-hand surgery analgesia

AAOS 2016: IV + oral acetaminophen comparable for pain and narcotic use following TJA

Acetaminophen is a suitable treatment for moderate osteoarthritis pain of the knee

Osteoarthritis Cartilage. 2009 Jan;17(1):1-7. Epub 2008 Jul 21

NSAIDs versus acetaminophen for treatment of knee and hip osteoarthritis

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Diclofenac versus acetaminophen versus placebo for treatment of symptomatic knee osteoarthritis

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ISAKOS 2015: Platelet-Rich Plasma favourable compared to acetaminophen for primary knee OA

Immediate- vs extended-release tramadol HCL/acetaminophen for pain following TKA

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Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

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AAOS 2016: Similar rates of nonunion with acetaminophen/NSAIDs in humeral shaft fractures

IV Titrated Morphine vs Hydrocodone/Acetaminophen for pain relief of lower extremity fractures in ED

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Efficacy of acetaminophen - with and without tramadol - for analgesia in extremity fracture fixation

J Bone Joint Surg Am. 2017 Nov 15;99(22):1908-1915

Lower pain and need for opioids with IV acetaminophen vs. placebo after total hip arthroplasty

J Arthroplasty. 2019 Jun;34(6):1155-1161. doi: 10.1016/j.arth.2019.02.033

Perioperative ibuprofen & acetaminophen vs. ibuprofen alone for analgesia in arthroplasty

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Morphine vs. mutlimodal acetaminophen/oxycodone for analgesia in painful acute fracture

Eur J Orthop Surg Traumatol. 2014 Oct;24(7):1305-9

Oxycodone/Acetaminophen vs. Acetaminophen Alone for Musculoskeletal Pain Refractory to Ibuprofen

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2021 21-Aug;():. 10.1111/acem.14231.

Preemptive/preventive acetaminophen reduces pain in lower extremity surgery

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TKA: Dual-opioid treatment reduces pain and adverse GI events vs. oxycodone/acetaminophen

Clin Ther. 2013 Apr;35(4):498-511. doi: 10.1016/j.clinthera.2013.03.002

Celecoxib versus acetaminophen for pain & MRI scores in chronic non-specific LBP

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Influences of route of acetaminophen administration and periarticular liposomal bupivacaine in TKA

J Arthroplasty. 2018 Jul;33(7S):S136-S141. doi: 10.1016/j.arth.2018.02.088