Addition of Acetaminophen to Multi-Modal Pain Management Protocol Reduces Pain and Opioid Use in TJA

Study Type:Therapy

OE Level Evidence:1

Journal Level of Evidence:1

The Efficacy and Safety of Acetaminophen in Total Joint Arthroplasty: Systematic Review and Direct Meta-Analysis.

J Arthroplasty. 2020 Oct;35(10):2715-2729.

Contributing Authors: YA Fillingham CP Hannon GA Erens K Mullen F Casambre V Visvabharathy WG Hamilton CJ Della Valle

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Synopsis

Seventeen randomized trials were included in this meta-analysis comparing the addition of acetaminophen or placebo to a multi-modal pain management protocol in patients undergoing total joint arthroplasty (hip or knee). Pooled outcomes of interest included post-operative pain, difference in sum of pain intensity, post-operative opioid consumption, and the risk of complications. Meta-analysis resul...