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9%
Synopsis: 46 patients (60 patellar tendons) were randomized to assess the efficacy of ultrasound-guided injection of autologous skin-derived, tenocyte-like cells in treating refractory patellar tendinosis.Patients received either injection with collagen-producing cells suspended in autologous plasma or injection with autologous plasma alone (control). The assessment at... Read More »
Level 2 RCT
9%
Synopsis: 8 ACE Reports (7 randomized controlled trials and 1 systematic review and meta-analysis, n=694) from the OrthoEvidence database assessing the effectiveness of corticosteroid injections in comparison to control injections (either saline or local anesthesia) for the treatment of lateral epicondylitis were included in this review.The purpose of this review was to determine the impact of corticosteroid injections on pain and physical function in comparison to these control treatments.As such, information and data on platelet-rich plasma (PRP) injection efficacy as a treatment was not included from reports.Statistical pooling of VAS pain scores and Quick DASH scores exhibited that corticosteroid injections provided significant pain relief, compared to control injections only in the short-term (6-12 weeks), while having no functional benefits over control injections at any time point within a 6 month period. Similar results were... Read More »
ACE Review
9%
Synopsis: 8 ACE Reports (all randomized controlled trials) from the OrthoEvidence database were included in this review/meta-analysis examining the effect of arthroscopic surgery and physical therapy in the treatment of degenerative tears of the meniscus and knee osteoarthritis.The purpose of this review was to determine if any differences in outcome were demonstrated between arthroscopy followed by physical therapy versus physical therapy alone, regarding pain, function, satisfaction, adverse events, or osteoarthritis progression.Pain results were pooled at 3 different time point: 2-3 months, 6 months, and 12-24 months postintervention.At short-term (2-3 months) and long-term (12-24 months) follow-up, pain was similar between groups, with no significant difference observed.There tended to be less pain experienced at 6 months following arthroscopy, however this only reached significance in the KOOS pain outcome and the clinical importance of this observation is unknown.Assessments of functional outcome, either pooled or qualitative, suggested no significant difference between groups as well. The rate of... Read More »
ACE Review
9%
Synopsis: 40 patients with a clinical diagnosis of chronic plantar fasciitis were randomly allocated to either receive polydeoxyribonucleotide (PDRN) or normal saline injections into the heel, once per week for a total of 3 injections.The purpose of the study was to determine if PDRN injections were a safe and effective treatment for this pathology as compared to a placebo.Results indicated that after 4 weeks, there were no significant differences in either Visual Analog Scale (VAS) pain or Manchester-Oxford Foot Questionnaire (MOXFQ) scores.However, at 12 weeks, results for both outcome measures significantly favored the PDRN group compared to the saline group. No treatment-related complications... Read More »
Level 2 RCT
9%
Synopsis: 73 patients with rotator cuff tendinopathy were randomized to one of three study treatment groups: (1) hypertonic dextrose prolotherapy injection directly to affected entheses, (2) saline injection directly to affected entheses, or (3) saline injection superficial to affected entheses.The purpose of this study was to investigate the clinical benefits of dextrose prolotherapy when compared to control groups by observing improved patient-reported pain scores, patient satisfaction scores, and ultrasound grading of regenerative effect. Results demonstrated that... Read More »
Author verified Level 2 RCT
9%
Synopsis: 82 patients with medial collateral ligament (MCL) injuries were randomized to management using a hinged brace mobilization or unprotected mobilization.The objective of this trial was to evaluate the effect of hinged bracing on functional outcomes and time to return to work, running and full sport.The results of this trial demonstrated no significant differences in the International Knee Documentation Committee (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) between groups. There were also... Read More »
Conference Report
9%
Synopsis: 111 patients with either unilateral or bilateral hip osteoarthritis were randomized to be treated with one of three injection protocols; platelet rich plasma, hyaluronic acid, or combined platelet rich plasma and hyaluronic acid.Patients were administered three weekly intra-articular injections of the allocated treatment, were followed-up for 12 months post-injection and assessed clinically using a visual analog scale for pain, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Harris Hip Score (HHS). Results demonstrated significantly... Read More »
Level 2 RCT
9%
Synopsis: 22 patients with chronic pancreatitis took 8 mg of delta-9-tetrahydrocannbinol (Δ9-THC) with placebo diazepam or placebo Δ9-THC with diazepam at 2 sessions in a randomly allocated sequence for this crossover trial.Blood samples were examined for the pharmacokinetic and pharmacodynamic properties of Δ9-THC, and reduction in pain was measured by the VAS scale.Bond and Lader visual analogue scales were used to assess mood and behavioral changes and the Bowdle questionnaire was used to assess the psychedelic effects of Δ9-THC.Results indicate that Δ9-THC 8 mg was not significantly effective for pain reduction compared to diazepam but was well-tolerated with mild and moderate adverse effects. There was no... Read More »
Level 2 RCT
9%
Synopsis: 36 randomized controlled trials were included in his meta-analysis which examined the use of platelet rich plasma (PRP) versus varying control interventions for various soft-tissue orthopaedic injuries and conditions, predominantly elbow tendinopathy and plantar fasciitis.Pooled results among patients with elbow tendinopathy demonstrated a lack of significant difference in pain or functional measures between PRP and control groups at 3 months, but significant differences in favour of PRP groups at 6 months.In patients with plantar fasciitis, pooled results demonstrated a lack of significant difference in pain scores between PRP and control at 3 months, while 6-month results significantly favoured PRP groups.When outcome on the AOFAS functional score were considered, pooled results significantly favoured PRP groups at 3 and 6 months. When effects were... Read More »
Level 1 Meta Analysis
9%
Synopsis: 357 patients with hip osteoarthritis were randomized to a single intraarticular injection of either hylan G-F 20 or placebo saline.Patients were assessed over 26-week follow-up for outcome on improvement in the first question of the WOMAC Pain subscale (WOMAC A1), response rate on the WOMAC A1 (minimum 2-pt improvement), the WOMAC Pain subscale overall, the WOMAC Function subscale, and the incidence of adverse events. Results at all... Read More »
Level 2 RCT