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Synopsis: Five randomized controlled trials were included in this meta-analysis which sought to investigate the efficacy of mesenchymal stem cell injections in patients with knee osteoarthritis.Included studies featured various control groups, including placebo injection, hyaluronic acid injection, and no injection, as well as various concomitant treatments, including high tibial osteotomy, microfracture, platelet rich plasma injection and hyaluronic acid injection.Accordingly, clinical heterogeneity was assumed.Data was pooled from 12-24 month time points. Analyses on visual... Read More »
Level 2 Meta Analysis
5%
Synopsis: 34 patients were included in this crossover trial which evaluated the effects of tetrahydrocannabinol (THC), cannabidiol (CBD, a 1:1 mixture of THC and CBD, and placebo sublingual spray in management of patients with chronic pain.Patients were randomized to the order in which they received each treatment for 1 week over a 4-week period, after which a 2nd cycle of 1-week treatments over 4 weeks was administered.The participants were compared on pain severity (VAS), sleep duration and quality, and adverse events. The results demonstrated... Read More »
Level 2 RCT
3%
Synopsis: 101 patients (106 shoulders) were randomized to investigate the efficacy of either an intra-articular injection or periarticular injection in the treatment of symptomatic acromioclavicular joints.Outcome measurements of pain and function were assessed up to 3 weeks post-injection.The results indicated that either injection provided similar, significant improvements in pain and function. There was no... Read More »
Author verified Level 1 RCT
3%
Synopsis: 111 patients with either unilateral or bilateral hip osteoarthritis were randomized to be treated with one of three injection protocols; platelet rich plasma, hyaluronic acid, or combined platelet rich plasma and hyaluronic acid.Patients were administered three weekly intra-articular injections of the allocated treatment, were followed-up for 12 months post-injection and assessed clinically using a visual analog scale for pain, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Harris Hip Score (HHS). Results demonstrated significantly... Read More »
Level 2 RCT
3%
Synopsis: 82 patients scheduled to undergo total knee arthroplasty (TKA) were randomized to receive either a preoperative motor sparing knee block (MSB) injection that targets the adductor canal and lateral femoral cutaneous nerve, or intraoperative periarticular infiltration (PAI) to compare their effects on duration of analgesia, postoperative quadriceps power, and length of hospital stay.Findings indicated that the MSB group reported a significantly longer duration of analgesia compared to the PAI group. Postoperative quadriceps power... Read More »
Conference Report
3%
Synopsis: 28 patients with knee osteoarthritis (OA) were randomized to the order in which they received either a pair of lateral wedged insoles or an off-the-shelf valgus knee brace for two consecutive weeks in this cross-over randomized trial.A 2 week washout period was used between treatments.The purpose of this study was to determine the biomechanical and clinical effects of these two treatments as assessed using knee kinematics and kinetics parameters, the Western Ontario and McMaster Universities Arthritis Index (WOMAC), and a 100mm visual analogue scale (VAS).Findings indicated a significantly reduced early stance external knee adduction moment (EKAM) in the lateral wedged insoles group compared to the valgus knee brace group, but knee varus angle was significantly reduced in the brace group compared to the insole group.Pain and functional outcomes were comparable between groups. Both treatment methods... Read More »
Author verified Level 2 RCT
3%
Synopsis: 60 patients with an acute anterior shoulder dislocation were randomized to either physician-guided self-reduction using the Boss-Holzach-Matter technique, or to physician-administered reduction using the Spaso technique.Patients were assessed for pain severity experienced during reduction and for the rate of successful reduction.Results demonstrated significantly lower patient-rated pain during reduction using the self-administered Boss-Holzach-Matter technique in comparison to the physician-administered Spaso technique. The rate of... Read More »
Author verified Level 2 RCT
3%
Synopsis: 29 studies were included in this meta-analysis comparing operative and non-operative treatment for acute Achilles tendon ruptures.The primary outcome of interest was the rate of re-rupture.Secondary outcomes included the rate of complications, functional outcomes, time to return to sports and time to return to work.The results revealed a significantly lower rate of re-rupture, but a higher rate of complications, in the operative group compared to the non-operative group.Similar findings to the primary analyses were observed in the sensitivity analyses based on early and late weight bearing status, high quality studies and studies conducted after the year 2000.There were no significant differences in re-rupture rate in studies utilizing accelerated functional rehabilitation. There was no... Read More »
Level 1 Meta Analysis
3%
Synopsis: Ninety-seven patients undergoing lumbar disc arthroplasty for the treatment of symptomatic degenerative disc disease were analyzed in this study assessing 1- and 2-year post-operative clinical outcomes.Outcomes of interest included back pain, complication rate, Oswestry Disability Index scores, quality of life measures, and patient satisfaction. Results of the... Read More »
Conference Report
1%
Synopsis: 76 patients diagnosed with adhesive capsulitis, having predominantly 1 shoulder pain for >3 months in the last 2 years, were randomized to undergo hydrodilatation with corticosteroid injection or just corticosteroid intra-articular injection.This study aimed to compare the clinical results between techniques.At 6 weeks, no major significant between-group differences in most of the outcome measures were recorded. There was a... Read More »
Level 2 RCT