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Synopsis: 80 patients with elbow tendinopathy and scheduled for needle tenotomy were randomized to adjuvant intratendinous injection or either platelet-rich plasma or lidocaine.Intratendinous injections were performed within areas of hypoechogenicity observed during ultrasound-guided tenotomy.Primary outcomes were the proportion of patients who demonstrated minimum reductions of 25% from baseline in the Disabilities of the Arm, Shoulder, and Hand (DASH) and pain on a visual analog scale (VAS). Results demonstrated no... Read More »
Level 2 RCT
2%
Synopsis: 50 patients with gluteal tendinopathy and trochanteric pain syndrome were randomized to three weekly sessions of focused extracorporeal shockwave therapy (f-ESWT) or ten daily sessions of therapeutic ultrasound (UST).Patients were assessed for pain and functional outcome at 2-month follow-up and 6-month follow-up.Numeric rating scale (NRS) for pain was significantly lower in the f-ESWT group compared to the UST group at 2 months and 6 months. Outcome on the... Read More »
Level 2 RCT
2%
Synopsis: 61 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were randomized to treatment with either a single intraarticular injection of bone morrow-derived mesenchymal stem cells (BM-MSC) or oral acetaminophen 500mg every 8 hours for 6 months.Patients were assessed for outcome on a visual analog scale for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Patients were assessed 1 week, 1 month and 6 month follow-up. Results demonstrated significantly... Read More »
Level 2 RCT
1%
Synopsis: 100 patients scheduled for total knee arthroplasty and had the knee placed in 60 degrees flexion for the first 24 hours after surgery were randomized to surgery with or without intraoperative use of a tourniquet.Patients were assessed for outcomes related to blood loss, pain scores on a visual analog scale, knee range of motion, knee circumference, and incidence of complications.For blood loss outcomes, intraoperative blood loss was significantly lower in the tourniquet group, while postoperative blood loss to drainage and hidden blood loss were significantly lower in the non-tourniquet group.Total blood loss and transfusion rate did not significantly differ between groups. Pain scores and... Read More »
Level 2 RCT
1%
Synopsis: 120 patients with symptomatic knee osteoarthritis were randomized to receive intra-articular (IA) injections of platelet rich plasma (PRP), hyaluronic acid (HA) or corticosteroid for the treatment of pain and improvement of function.Outcomes of interest included the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, Visual Analog Scale (VAS) for pain and adverse events.Follow up was performed at 3, 6.9 and 12 months.The results of the study found significant improvements from pre-treatment scores in both WOMAC and VAS pain outcomes in all three groups.Moreover at 6, 9 and 12 months, the PRP group showed significantly favourable WOMAC scores compared to both the hyaluronic acid and corticosteroid injection groups. There were no... Read More »
Level 2 RCT
1%
Synopsis: 84 patients with frozen shoulder were randomized to perform a self-exercise program delivered conventionally or with the aid of a smartphone application.The primary outcome of interest was pain, measured on a Visual Analog Scale (VAS).Secondary outcomes included range of motion (in forward flexion, abduction, internal rotation, external rotation).Usability questionnaires (TAM-2; USE) were administered to determine the feasibility of the application.The results from the trial found no significant differences between the two groups in VAS pain scores nor range of motion in all measured directions. The usability questionnaires... Read More »
Level 2 RCT
1%
Synopsis: 26 patients with chronic lateral epicondylitis were randomized to mini-open release of the extensor carpi radialis brevis or to sham surgery with incision and exposure of the ECRB.Based on the available results, there were no significant differences between the ECRB release group and sham group in patient-reported pain frequency, pain severity, elbow stiffness, functional difficulty, elbow range of motion, grip strength, or wrist extension strength between the 2-week and 2.5-year follow-up. The trial initially... Read More »
Author verified Level 2 RCT
1%
Synopsis: 80 patients with Kellgren-Lawrence grade II-IV knee osteoarthritis were randomized to a course of five weekly intraarticular injections of either low molecular weight hyaluronic acid or high molecular weight hyaluronic acid.Patients were assessed for response the therapy in a visual analog scale for pain, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and medial and lateral joint space width on radiograph. No significant differences... Read More »
Level 2 RCT
1%
Synopsis: 60 patients with Kellgren-Lawrence grade II-II knee osteoarthritis were randomized to one of five treatments: bone marrow--derived allogeneic mesenchymal stromal cell injection at either a 25, 50, 75, or 150 million cell dose, or placebo injection.At each dose level, randomization was conducted at a 2:1 ratio of intervention to placebo; therefore a total of 10 patients were administered at each dose level, and 20 patients overall were administered placebo.Analyses were separated by lower and higher dose levels, with the patients of the placebo groups at the first two dose levels treated as one group (placebo group 1), and the patients of the placebo groups at the last two dose levels treated as one group (placebo group 2).The 25M and 50M dose groups were analyzed relative to placebo group 1, and 75M and 150M dose groups were analyzed relative to placebo group 2.Overall, incidence of adverse events were similar between treatment and placebo groups, with the most common AEs documented related to arthralgia and injection site pain.Only results of the comparisons between the 25M, 50M, and placebo 1 group were reported. Despite the greatest... Read More »
Level 2 RCT
1%
Synopsis: 60 patients with bilateral secondary knee osteoarthritis to corticosteroid-induced osteonecrosis were randomized to have one knee treated with subchondral injection of mesenchymal stem cells, and one knee treated with total knee arthroplasty.Patients were assessed over a minimum of 8 years after treatment.Results demonstrated no significant difference between groups in outcome on the Knee Society Score at final follow-up. Rate of secondary... Read More »
Author verified Level 2 RCT