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Synopsis: Five randomized controlled trials were included in this meta-analysis which sought to investigate the efficacy of mesenchymal stem cell injections in patients with knee osteoarthritis.Included studies featured various control groups, including placebo injection, hyaluronic acid injection, and no injection, as well as various concomitant treatments, including high tibial osteotomy, microfracture, platelet rich plasma injection and hyaluronic acid injection.Accordingly, clinical heterogeneity was assumed.Data was pooled from 12-24 month time points. Analyses on visual... Read More »
Level 2 Meta Analysis
4%
Synopsis: 84 adult patients with symptomatic isolated interstitial supraspinatus tears were randomized to receive infiltration with platelet rich plasma (PRP) or normal saline.A total of two injections were administered separated by 1 month.The primary outcome of interest was the change in lesion volume.Secondary outcomes of interest included pain on a Visual Analog Scale (VAS), the Single Assessment Numerical Evaluation (SANE), Constant score, the American Shoulder and Elbow Surgeons (ASES) score, the incidence of adverse events and the performance of surgical repair.Follow up was performed at 7 and 12 months after the first injection.Results revealed no significant differences between the PRP and control groups in the change in lesion volume, VAS pain, SANE score, Constant score, and ASES score.The incidence of adverse events was significantly higher in the PRP group. No significant difference... Read More »
Level 1 RCT
4%
Synopsis: 60 patients with Kellgren-Lawrence grade I-II knee osteoarthritis were randomized to treatment with either intraarticular hyaluronic acid or oral hyaluronic acid.Patients allocated to IAHA were administered three weekly injection, and patients allocated to oral HA were given daily tablets to take for 40 days.Outcome measures included pain on a visual analog scale and the American Knee Society Score. Within-group improvement from... Read More »
Level 2 RCT
2%
Synopsis: 60 patients with low back pain and lumbar radiculopathy were randomized to a 2-week physiotherapy program with or without the addition of spinal mobilization technique in sessions with physiotherapists.To be enrolled, patients had to have demonstrated a positive response to a trial application of spinal mobilization.Patients were assessed for outcome related to leg pain, back pain, disability and function after 2 weeks, 3 months, and 6 months. Results demonstrated better... Read More »
Level 2 RCT
2%
Synopsis: 14 studies, including 8 randomized controlled trials, were included in this meta-analysis which had the purpose of evaluating the prophylactic effects of preventative neuromuscular training in female athletes afflicted with anterior cruciate ligament injuries.The four types of exercise in the training program – balance, proximal control, strength, and plyometrics – were evaluated in subgroup analyses to determine efficacy in terms of number of anterior cruciate ligament injuries incurred during the intervention.The results of this study indicated that strength and proximal control training offered the greatest benefits in terms of preventing injury.However, no significant reduction was seen in the incidence of injuries in patients who engaged in balance or plyometric activities in comparison to those who did not. Additionally, subgroup analysis... Read More »
Author verified Level 2 Meta Analysis
2%
Synopsis: 1625 NCAA Division I and II men's soccer players were included in this cluster randomized controlled trial.The purpose of this study was to compare the efficacy of the FIFA 11+ injury prevention program in male collegiate soccer players in terms of injury rate and time lost due to injury in comparison to a control group.The results displayed significantly lower numbers of injuries and days lost to injury in the FIFA 11+ group. Within the FIFA... Read More »
Level 2 RCT
2%
Synopsis: 23 randomized controlled trials were included in this meta-analysis which compared component alignment, operative time, length of stay and blood loss between cases of total knee arthroplasty completed with patient-specific instrumentation and cases completed with conventional instrumentation.Absolute deviation and incidence of outliers did not significantly differ between groups for overall coronal lower limb alignment, coronal and sagittal femoral component alignment, and coronal and sagittal tibial component alignment.While absolute deviation in axial femoral component alignment was lower among PSI groups, the difference between groups in outliers in axial femoral component alignment was not significant.Operative time was statistically significantly shorter among PSI groups by approximately 7.5 minutes, and blood loss was statistically significantly lower among PSI groups by approximately 83mL. Length of stay... Read More »
Level 1 Meta Analysis
1%
Synopsis: This meta-analysis identified 8 controlled studies that examined anterior cruciate ligament (ACL) injury prevention programs.The purpose of this meta-analysis is to examine the effectiveness of ACL prevention programs and to determine if there is evidence for the "best" program, while assessing the quality of the current literature on ACL injury prevention. The pooled results... Read More »
Author verified Level 1 Meta Analysis
1%
Synopsis: 75 patients with lateral epicondylitis and scheduled for release of the extensor carpi radialis brevis (ECRB) origin were randomized to either arthroscopic or open surgery.Patients were assessed over the first 12 months after surgery for the primary outcome of disability on the Disabilities of the Arm, Shoulder, and Hand score, and secondary outcomes of pain, function on the Patient Rated Tennis Elbow Evaluation (PRTEE), and grip strength. Results demonstrated no... Read More »
Level 2 RCT
1%
Synopsis: 50 patients scheduled for total knee arthroplasty were randomized to the use of either patient specific instrumentation (PSI) or conventional instrumentation (CI).Outcomes of interest included contact location on the medial and lateral condyles, the magnitude of excursion, the incidence of condylar separation and the rate of neutral alignment.Follow up was performed 2 years post-operation.Results revealed no significant differences in all outcomes between the PSI and CI groups. Furthermore, no differences... Read More »
Conference Report