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20%
14%
13%
12%
12%
11%
7%
4%
2%
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2%
1%
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100%
7%
Synopsis: 120 patients with Kellgren-Lawrence grade II-IV knee osteoarthritis were randomized to intraarticular injection with either a combination of hyaluronic acid and corticosteroid, or hyaluronic acid alone.Patients were followed-up for 6 months posttreatment for outcome related to pain on a visual analog scale and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).Between groups, bth VAS pain and WOMAC assessments significantly favoured the HA+CS group compared to the HA alone group at 1 week, 1 month, and 3 months; differences between groups at 6 months were not significant. However, when the... Read More »
Level 2 RCT
3%
Synopsis: 1583 patients with symptomatic knee osteoarthritis were randomized to either glucosamine monotherapy, chondroitin monotherapy, combined glucosamine and chondroitin therapy, celecoxib 200mg daily, or placebo.Patients were assessed over 24 weeks of treatment.In the primary analysis, only the celecoxib group demonstrated a significantly higher rate of patients attaining the primary efficacy endpoint - a reduction of WOMAC pain by a minimum of 20% relative to baseline - compared to placebo. However, when only... Read More »
RCT
3%
Synopsis: 234 patients with carpal tunnel syndrome were randomized to a single injection of 20mg methylprednisolone acetate or 6 weeks of nightly splinting.Patients were assessed primarily for outcome on the Boston Carpal Tunnel Questionnaire at 6 weeks and 6 months.In addition, cost-utility analysis was performed.Results for the BCTQ Symptom Severity Score and Functional Status Score significantly favoured the CS injection group compared to the nightly splinting group at 6 weeks, while differences at 6 months were not significant. On a 6-month... Read More »
Level 2 RCT
2%
Synopsis: 82 patients with symptomatic knee osteoarthritis were randomized to either treatment with a topical flaxseed oil preparation or to placebo.Patients were to apply allocated treatment three times daily for 6 weeks.The outcome measure was the Knee Injury and Osteoarthritis Outcome Score (KOOS). Improvement in each... Read More »
Level 2 RCT
2%
Synopsis: 150 patients with an acute displaced midshaft clavicle fracture were randomized to treatment through either open reduction and internal fixation with a plate or nonoperative management with sling immobilization.Patients were followed-up at 6 weeks, 3 months, 6 months, and 12 months for outcome related to the Disabilities of the Arm, Shoulder, and Hand score, the Constant score, and the incidence of nonunion.Outcome on both the DASH score and the Constant score significantly favoured the plate group compared to the sling group at 6-week and 3-month follow-up, but no significant between-group differences were observed in the measures at 6 months or 12 months. The incidence of... Read More »
Level 2 RCT
2%
Synopsis: 21 patients with stage 1 or 2 adhesive capsulitis were randomized to corticosteroid injection therapy with or without the addition of a 3-month physiotherapy program after injection.Patients were followed for outcome on the Shoulder Pain and Disability Index primarily, as well as for range of motion, pain scores, and satisfaction.Follow-up was performed at 6 weeks, 12 weeks, and 26 weeks.Results demonstrated lower SPADI score at 6 weeks in the group which participated in PT after injection.In addition, range of motion was significantly higher in the PT group in forward flexion at 6 weeks, and in abduction and external rotation at 6 and 12 weeks. Differences between groups... Read More »
Level 2 RCT
2%
Synopsis: 19 randomized controlled trials were included in this network meta-analysis which sought to quantify the effects of various nonoperative modalities and control for treatment of chronic ankle instability.When compared to control, approaches which demonstrated a significant effect size on the star-excursion balance test when assessed post-treatment included balance training plus strength training, balance training plus mobilization, strength training alone, balance training alone, and manual therapy. In addition, combined... Read More »
Level 1 Meta Analysis
2%
Synopsis: 73 patients with chronic plantar heel pain were randomized to five sessions of either treatment with percutaneous needle electrolysis (PNE) or to control with placebo intervention.Patients were assessed for outcome related to first step heel pain on a visual analog scale, the Foot an Ankle Ability Measure (FAAM) Activities of Daily Living (ADL) score, and plantar fascia thickness on ultrasound over 24-week follow-up. After 24 weeks,... Read More »
Level 1 RCT
2%
Synopsis: 147 patients with a diagnosis of plantar fasciities were randomized to injection therapy with either 40mg of micronized dehydrated human amnion/chorion membrane (dHACM) in 1mL saline or to placebo saline alone.In addition to injection, all patients were managed with orthoses for 2 weeks after injection.Patients were assessed primarily for change in visual analog pain score (VAS pain) from baseline to 3 months post-injection. Results demonstrated a... Read More »
Level 2 RCT
2%
Synopsis: 35 patients with chronic, nonspecific low back pain were randomized in this exploratory trial to the addition of either active or sham transcranial direct current stimulation (tDCS) sessions prior to starting a group exercise program for 1 month.The tDCS sessions were completed over 5 consecutive days prior to group exercise intervention.Patients were assessed primarily for pain response during and after tDCS intervention, following completion of the group exercise program, and at 1-month follow-up. Within-group reductions in visual analog scale (VAS) pain score after each tDCS session were significant in the active tDCS group, but not in the sham tDCS group.Overall reduction in pain from baseline to 1-month follow-up was also significantly greater in the active tDCS group compared to the sham tDCS group, as was the rate of responders (ie.minimum 30% reduction in VAS). Most common adverse... Read More »
Level 2 RCT