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Synopsis: 26 randomized controlled trials were included in this meta-analysis which compared efficacy and safety outcomes of glucosamine monotherapy, chondroitin monotherapy, and combined therapy to placebo.A total of 30 distinct comparison were available among the included studies, with follow-up ranging from 4 weeks to 144 weeks.Pooled estimates demonstrated significant effects of chondroitin on pain and function measures compared to placebo, while glucosamine demonstrated significant a significant effect on stiffness measures.Combined therapy failed to demonstrate a significant effect compared to placebo for any efficacy measures. No significant differences... Read More »
Level 2 Meta Analysis
3%
Synopsis: 29 randomized controlled trials were selected for inclusion in this meta-analysis which compared the rates of heterotopic ossification after total hip arthroplasty between groups of patients treated with selective non-steroidal anti-inflammatory drugs (NSAIDs), groups treated with non-selective NSAIDS, and groups treated with placebo.Compared to placebo, both selective and non-selective NSAID groups demonstrated significantly lower rates of heterotopic ossification development. No significant difference... Read More »
Level 1 Meta Analysis
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Synopsis: 72 patients with lateral epicondylitis were randomized to treatment with either four weekly sessions of radial extracorporeal shockwave therapy or four weeks of wrist extensor splinting.Patients were assessed for outcome after 4 weeks, 12 weeks, and 24 weeks. No significant between-group... Read More »
Level 2 RCT
2%
Synopsis: 356 patients who presented to primary care with traumatic knee symptoms were randomized to either receive a referral for MRI by the general practitioner, or to usual care as per the Dutch clinical guideline with potential referral to an orthopaedic surgeon.The purpose of this study was to determine if a referral for MRI from primary care was a cost-effective treatment pathway for this patient population. Assessment of cost-utility... Read More »
Level 2 RCT
2%
Synopsis: 25 randomized controlled trials were included in this meta-analysis which compared bisphosphonate therapy to control intervention for effect on postoperative bone mineral density following total hip and total knee arthroplasty.Overall, in THA and TKA cohorts, bisphosphonate therapy was associated with significantly greater total periprosthetic bone mineral density compared to control intervention up to 5-10 year follow-up. Among THA cohorts,... Read More »
Level 1 Meta Analysis
2%
Synopsis: Four randomized controlled trials were included in this meta-analysis which aimed to evaluate the effect of platelet-rich plasma injections in addition to eccentric exercises relative to saline injections in addition to eccentric exercise. Pooled results on VISA-A scores, tendon thickness, and color Doppler activity demonstrated no significant differences between PRP and saline injections groups. Read More »
Level 1 Meta Analysis
1%
Synopsis: 69 patients with a closed, displaced clavicle fracture (Robinson type 2B) were randomized to surgery with open reduction and internal fixation with a plate, or two nonoperative treatment with an arm pouch sling.Patients were followed over 24-month follow-up for union, incidences of nonunion and malunion, complications, and function through the Constant score.Results demonstrated no significant differences in the rate of nonunion between groups, though time to union was significantly shorter in the plate group compared to sling group. Additionally, function at... Read More »
Level 2 RCT
1%
Synopsis: 82 patients with a complete Achilles tendon rupture were randomized to either percutaneous repair or open repair.Follow-up was performed over 12 months after surgery for functional scores, range of motion, complications, and rerupture rate.Results demonstrated no significant differences between groups for any of the assessed outcome measures. No patient in... Read More »
Author verified Level 2 RCT
1%
Synopsis: 6 randomized controlled trials were included in this systematic review to determine if the addition of hydrodilatation to a corticosteroid injection provides an improvement in pain-free range of motion and pain relief in patients with adhesive capsulitis.The results of this systematic review indicated that for range of motion results at 4-6 weeks, one of three studies reported a significant difference in favour of the hydrodilatation group, at 8-12 weeks, two of four studies reported a significant difference in favour of the hydrodilatation group, and at 16-24 weeks, neither of two studies reported a significant difference in favour of the hydrodilatation group. The available evidence... Read More »
Author verified Level 2 Meta Analysis
1%
Synopsis: 80 patients with plantar fasciitis were randomized to local injection of either platelet-rich plasma or corticosteroid (methylprednisolone).Patients were assessed for pain and functional scores at 1, 3, and 6 months after injection. Results demonstrated no... Read More »
Author verified Level 2 RCT