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100%
8%
Synopsis: 72 patients with knee osteoarthritis were randomized to intraarticular injection with either 40mg methylprednisolone or 30m ketorolac.Patients were assessed for improvement over 6-week follow-up in numeric rating scale (NRS) pain scores, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Oxford Knee Score (OKS).Results demonstrated significant significant within-group improvement in both groups for NRS pain score and WOMAC scores. However, for OKS... Read More »
Conference Report
5%
Synopsis: Five randomized controlled trials were included in this meta-analysis which sought to investigate the efficacy of mesenchymal stem cell injections in patients with knee osteoarthritis.Included studies featured various control groups, including placebo injection, hyaluronic acid injection, and no injection, as well as various concomitant treatments, including high tibial osteotomy, microfracture, platelet rich plasma injection and hyaluronic acid injection.Accordingly, clinical heterogeneity was assumed.Data was pooled from 12-24 month time points. Analyses on visual... Read More »
Level 2 Meta Analysis
3%
Synopsis: 126 patients with idiopathic adhesive capsultitis were randomized to intra-articular glenohumeral corticosteroid injection, subacromial corticosteroid injection, or a combination of both intra-articular and subacromial corticosteroid injection.The purpose of this study was to determine if a combined injection strategy offered better patient-reported clinical outcomes when compared to intra-articular injection alone or subacromial injection alone. American Shoulder and... Read More »
Level 2 RCT
3%
Synopsis: Seven randomized controlled trials were included in this meta-analysis evaluating the efficacy of corticosteroid injections in the treatment of enthesopathy of the extensor carpi radialis brevis origin.Included RCTs featured local anesthetic or placebo saline injections as a control.Results demonstrated significantly lower pain at 1 month with corticosteroid versus control injections, but no significant difference at 3 and 6 months. Functional scores and... Read More »
Author verified Level 1 Meta Analysis
3%
Synopsis: 50 patients with chronic, nonspecific neck pain were randomized to an 8-week exercise program of either craniocervical flexion exercises or isometric neck exercises.Patients were assessed at 4 and 8 weeks after enrollment for outcomes of pain on a visual analog scale (VAS), the Neck Disability Index (NDI), and cervical range of motion in flexion-extension, lateral flexion, and rotation.Results demonstrated significant within-group improvement after 4 and 8 weeks in both groups for all of the above measures. The group treated... Read More »
Level 2 RCT
3%
Synopsis: 29 studies were included in this meta-analysis comparing operative and non-operative treatment for acute Achilles tendon ruptures.The primary outcome of interest was the rate of re-rupture.Secondary outcomes included the rate of complications, functional outcomes, time to return to sports and time to return to work.The results revealed a significantly lower rate of re-rupture, but a higher rate of complications, in the operative group compared to the non-operative group.Similar findings to the primary analyses were observed in the sensitivity analyses based on early and late weight bearing status, high quality studies and studies conducted after the year 2000.There were no significant differences in re-rupture rate in studies utilizing accelerated functional rehabilitation. There was no... Read More »
Level 1 Meta Analysis
2%
Synopsis: 28 patients with chronic lateral epicondylitis were randomized to receive treatment with either a single injection of 3mL autologous blood or 3mL of platelet rich plasma (PRP) under ultrasound guidance.Patients who received PRP displayed greater VAS pain score improvement at all follow-up visits; however, significance was only observed at 6 week follow up. Additionally, it was... Read More »
Author verified Level 2 RCT
2%
Synopsis: Femoral neck fractures, a type of hip fracture, are a common and disabling injury, particularly given an ageing population in many countries.Throughout the past half-century, multiple different treatments have evolved for the treatment of these fractures, and these include sliding hip screws, cannulated screws, hemiarthroplasty (HA), and total hip arthroplasty (THA).Given that femoral neck fractures have the potential to compromise blood flow to the femoral head, arthroplasty options have gained prominence in recent years.However, it remains unclear which of the two options (THA or HA) is optimal in this population.Thus, in this definitive, landmark randomized controlled trial, which is by far the largest of its kind to date, the investigators randomized 1495 patients 50 years of age older with a displaced femoral neck fracture to undergo HA or THA.The trial was conducted across 80 centres in 10 different countries.Primary outcome was a secondary hip procedure within 24 months.Secondary endpoints included death, serious adverse events, hip-related complications, health-related quality of life, function, and overall health.There was no significant difference between the two groups in terms of revision rate, mortality, serious adverse events, revision procedures, EQ-5D, timed up and go test, or Short-Form 12 scores.There was a trend toward higher dislocation rates in THA, though this was not statistically significant.There was a significant difference in favour of THA on the WOMAC total and sub-scores, though this difference fell below the minimal clinically important threshold.Overall, in the absence of a convincing indication for THA, HA is a comparable treatment for femoral neck fracture which does not result in a significant difference in revision rate.There may be a slightly higher rate of serious adverse events with THA, and slightly better function with THA, though these differences may not reach clinical significance. Read More »
Level 1 RCT
2%
Synopsis: Previous studies have established the success of non-operative treatment following Achilles tendon rupture.37/60 patients were analyzed in this follow-up study comparing an early weight-bearing protocol to standard weight-bearing protocol during dynamic rehabilitative treatment of acute Achilles tendon ruptures.The primary outcome of interest was the Achilles Tendon Rupture Score (ATRS).Secondary outcomes of interest included heel raise height and work, as well as the return to level (heavy, light but active, sedentary) of work and sporting, and the incidence of re-rupture.Follow up was performed at 4.5 years post-operation.At 4.5 years, there were no significant differences between the early weight-bearing and usual care groups in ATRS score, heel raise height or heel raise work.All 37 patients had return to some level of work by the 4.5 year follow up, and 33/37 patients had returned to some level of sporting activity. Three cases of... Read More »
Level 2 RCT
2%
Synopsis: Six ACE Reports were identified from the OrthoEvidence database which compared intra-articular injection(s) of hyaluronic acid to corticosteroid in the treatment of osteoarthritis of the knee.All of the included studies were randomized controlled trials which reported pain and/or functional outcomes within 6 months of intervention.Pooled analysis of pain on a visual analog scale indicated that pain relief was significantly better with hyaluronic acid injections at both 3 and 6 months follow-up; however, this finding was strongly influenced by two studies of lower methodological quality. No significant differences between hyaluronic acid and corticosteroid injections were observed in any functional outcome measurement.Due to incomplete or lack of reporting adverse events, an assessment of safety could not be performed along with this review. Furthermore, these findings... Read More »
ACE Review