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Multimodal analgesia is safer and more effective than PCA after minimally-invasive TKA

J Arthroplasty. 2014 Feb;29(2):329-34. doi: 10.1016/j.arth.2013.06.005. Epub 2013 Jul 11.

RCT Arthroplasty Lower Extremity Knee Pain Hydromorphone Ondansetron Metoclopramide Minimally-Invasive TKA Multimodal Analgesic Regimen Patient-Controlled Analgesia PCA - Hide

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Periarticular multimodal drug injections effective and safe analgesic for TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Aug;22(8):1949-57. doi: 10.1007/s00167-013-2566-0. Epub 2013 Jun 20.

Meta-analysis Arthroplasty Lower Extremity Knee Epinephrine Anaesthesia Analgesic Injections Corticosteroid Local Infiltration Periarticular Multimodal Placebo Replacement TKA - Hide

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Postoperative analgesic effect of multimodal shoulder injection after rotator cuff repair

Knee Surg Sports Traumatol Arthrosc. 2013 Dec;21(12):2877-83. doi: 10.1007/s00167-012-2202-4. Epub 2012 Sep 19

RCT Shoulder & Elbow Upper Extremity Shoulder Muscle Rotator Cuff Tear Tears Wooyoung Medical Accufuser Plus Fentanyl Ketorolac Analgesic Arthroscopic Injection Intravenous Patient-Controlled Analgesia IV PCA Multimodal - Hide

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Satisfaction and adverse events improved with multimodal analgesia in elbow surgery

Orthop Traumatol Surg Res. 2013 Dec;99(8):895-901. doi: 10.1016/j.otsr.2013.09.005. Epub 2013 Oct 30

RCT Shoulder & Elbow Osteoarthritis Appendicular Upper Extremity Upper Extremity Elbow Joint Ligament Arthritis Dislocation Fracture Pain Ropivacaine Epinephrine Ketorolac Oxycodone Butorphanol Multimodal Analgesia Patient-Controlled Analgesia - Hide

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Multimodal drug cocktail an effective analgesic treatment for ACL reconstruction

Arthroscopy. 2012 May;28(5):649-57. Epub 2012 Jan 26

RCT Sports Medicine Bone Patella Joint Ligament Pain Ropivacaine Injection Periarticular Multimodal Reconstruction - Hide

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Lower pain and need for opioids with IV acetaminophen vs. placebo after total hip arthroplasty

J Arthroplasty. 2019 Jun;34(6):1155-1161. doi: 10.1016/j.arth.2019.02.033

RCT Arthroplasty Lower Extremity Hip Pain Intravenous Acetaminophen IV Acetaminophen Multimodal Analgesia Protocol - Hide

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Beneficial effect on pain & ROM with periarticular multimodal drug injection in TKA & THA

J Arthroplasty. 2013 Dec;28(10):1882-7. doi: 10.1016/j.arth.2013.06.031. Epub 2013 Aug 1

Meta-analysis Arthroplasty Lower Extremity Hip Knee Pain Analgesia Local Infiltration Opioid Periarticular Injection Periarticular Multimodal Placebo Prosthesis Replacement ROM THA TKA - Hide

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THA: No benefit of high-volume ropivacaine infiltration to multimodal oral analgesia

Acta Orthop. 2011 Aug;82(4):423-6. Epub 2011 Jul 13

RCT Arthroplasty Lower Extremity Hip Ropivacaine Celecoxib Morphine Gabapentin Analgesia Bilateral High-Volume Infiltration Multimodal Oral Placebo Saline THA - Hide

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Evaluating single-dose betamethasone for analgesia after outpatient knee arthroscopy

J Anesth. 2016 Oct;30(5):803-10

RCT Sports Medicine Lower Extremity Knee Betamethasone Anaesthesia Analgesia Arthroscopy Induction Of Anesthesia Intravenous Injection Placebo - Hide

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Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

J Arthroplasty. 2017 Oct;32(10):3029-3033

RCT Arthroplasty Lower Extremity Knee Hydromorphone Care Intravenous Acetaminophen IV Multimodal Analgesia Oral Acetaminophen Oral Placebo - Hide

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40 vs 8mg dexamethasone dose: similar analgesia reported after shoulder surgery

Acta Anaesthesiol Scand. 2014 Jul;58(6):751-8. doi: 10.1111/aas.12333. Epub 2014 May 13.

RCT Shoulder & Elbow Upper Extremity Shoulder Bone Subacromial Joint Acromioclavicular Pain Dexamethasone Intravenously Multimodal Analgesic Regimen Placebo - Hide

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Preemptive analgesia may reduce pain & postop complication following lumbar fusion surgery

Eur Spine J. 2016 May;25(5):1614-9.

RCT Spine Stenosis Lumbar Pain Celecoxib Oxycodone Pregabalin Acetaminophen Fusion Surgery Intravenous Morphine Multimodal Analgesia Preemptive Analgesia - Hide

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Improved pain and patient satisfaction with periarticular multimodal drug injection in TKA

J Bone Joint Surg Am. 2006 May;88(5):959-63

RCT Arthroplasty Lower Extremity Knee Pain Injection Periarticular Multimodal TKA - Hide

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Steroid addition to multimodal cocktail periarticular injection safe and effective in TKA

J Orthop Surg Res. 2015 May 22;10(1):75

Meta-analysis Arthroplasty Lower Extremity Knee Glucocorticoid Drainage Multimodal Periarticular Injection ROM Steroid Unilateral TKA - Hide

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OTA 2016: Peri-incisional multimodal drug injections in femur fracture surgery

RCT Trauma Bone Femur Fracture Ropivacaine Epinephrine Morphine Injections Multimodal - Hide

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Obturator Nerve Block Does Not Provide Relief Following Total Hip Arthroplasty

Regional anesthesia and pain medicine. 2021 21-Aug;():. 10.1136/rapm-2021-102531

RCT Peri-Operative Appendicular Lower Extremity Hip SonoSite Nerve Block Placebo Nerve block B. Braun Obturator Nerve Block - Hide

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ISAKOS2017: Additional lidocaine patch further reduces pain alongside standard analgesic plan in TKA

RCT Arthroplasty Lower Extremity Knee Pain Analgesic Regimen Analgesics Lidocaine Patches - Hide

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No analgesic benefit of nefopam in treatment of patients undergoing arthroscopic rotator cuff repair

J Clin Med. 2019 Apr 24;8(4). pii: E553. doi: 10.3390/jcm8040553

RCT Shoulder & Elbow Upper Extremity Muscle Rotator Cuff Tear Analgesia Analgesic Arthroscopic - Hide

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TKA: Periarticular drug injection added to standard analgesia decreases pain

Knee. 2012 Aug;19(4):253-9. Epub 2011 Apr 19

RCT Arthroplasty Lower Extremity Knee Pain Ropivacaine Analgesic Injections Control Protocol Periarticular Multimodal TKA - Hide

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Multimodal analgesic protocol reduces postoperative pain for TKA

J Arthroplasty. 2013 Sep;28(8):1274-7

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Pain Ropivacaine Epinephrine Morphine Ketorolac Clonidine Analgesic Control Multimodal Saline Solution - Hide

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Multimodal analgesia is safer and more effective than PCA after minimally-invasive TKA

Periarticular multimodal drug injections effective and safe analgesic for TKA

Postoperative analgesic effect of multimodal shoulder injection after rotator cuff repair

Satisfaction and adverse events improved with multimodal analgesia in elbow surgery

Multimodal drug cocktail an effective analgesic treatment for ACL reconstruction

Lower pain and need for opioids with IV acetaminophen vs. placebo after total hip arthroplasty

Beneficial effect on pain & ROM with periarticular multimodal drug injection in TKA & THA

THA: No benefit of high-volume ropivacaine infiltration to multimodal oral analgesia

Evaluating single-dose betamethasone for analgesia after outpatient knee arthroscopy

Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

40 vs 8mg dexamethasone dose: similar analgesia reported after shoulder surgery

Preemptive analgesia may reduce pain & postop complication following lumbar fusion surgery

Improved pain and patient satisfaction with periarticular multimodal drug injection in TKA

Steroid addition to multimodal cocktail periarticular injection safe and effective in TKA

OTA 2016: Peri-incisional multimodal drug injections in femur fracture surgery

Obturator Nerve Block Does Not Provide Relief Following Total Hip Arthroplasty

ISAKOS2017: Additional lidocaine patch further reduces pain alongside standard analgesic plan in TKA

No analgesic benefit of nefopam in treatment of patients undergoing arthroscopic rotator cuff repair

TKA: Periarticular drug injection added to standard analgesia decreases pain

Multimodal analgesic protocol reduces postoperative pain for TKA

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