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Efficacy of Preemptive Multimodal Analgesia Initiated at Various Time Points Before TKA
March 2025
Efficacy of Preemptive Multimodal Analgesia Initiated at Various Time Points Before TKA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Efficacy of preemptive multimodal analgesia initiated at various time points before total knee arthroplasty: a prospective, double-blind randomized controlled trial.
Arch Orthop Trauma Surg. 2024 Dec 12;145(1):23.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
This prospective, double-blind randomized controlled trial included 120 patients undergoing total knee arthroplasty (TKA) to evaluate the efficacy of preemptive multimodal analgesia (PMA) administered at different time points before surgery. Patients were divided into three groups receiving PMA (200 mg celecoxib and 150 mg pregabalin) at either 48 hours (Group A), 24 hours (Group B), or 1 hour (Gr...
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