Oral Nefopam for Multimodal Analgesia After Total Knee Arthroplasty
Oral Nefopam for Multimodal Analgesia After Total Knee Arthroplasty
Efficacy of Oral Nefopam on Multimodal Analgesia in Total Knee Arthroplasty: A Prospective, Double-Blind, Placebo-Controlled, Randomized Trial.
J Arthroplasty . 2024 Aug;39(8):2061-2067.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred patients with knee osteoarthritis undergoing primary total knee arthroplasty were randomized to receive either oral nefopam (40 mg twice daily) alongside celecoxib and pregabalin (n=50) or a placebo alongside the same regimen (n=50). The primary outcome was postoperative consumption of rescue analgesics (oxycodone and morphine). Secondary outcomes included pain scores (VAS) at rest and...
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