n our previous OE Original (COVID-19 Variants of Concern: Will There Be A Third Wave?) published in February, we discussed the evidence regarding three emerging SARS-CoV-2 variants of concern (VOCs), including i) the B.1.1.7 variant, first reported in the United Kingdom (UK) in September 2020; ii) B.1.351, first identified in October 2020 in cases from South Africa; and iii) P.1, detected in Japan in January 2021 from a traveler originating from Brazil. We expressed our concerns that “A third pandemic wave that is driven by the SARS-CoV-2 VOCs is possible in the near future ...” Since February, the surge in SARS-CoV-2 VOCs-related COVID-19 cases has swept many countries and regions. The World Health Organization (WHO) reported that as of April 27th, a total of 139 countries have reported..I...