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Aspirin reduces risk of recurrence in patients with unprovoked venous thromboembolism

N Engl J Med. 2012 May 24;366(21):1959-67. doi: 10.1056/NEJMoa1114238

RCT Metabolic Disorders Thromboembolism Bayer Aspirin Placebo - Hide

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POISE 2 (Part 1): The safety and efficacy of aspirin following non-cardiac surgery

N Engl J Med. 2014 Apr 17;370(16):1494-503. doi: 10.1056/NEJMoa1401105. Epub 2014 Mar 31

RCT General Orthopaedics Vascular Bayer Clonidine Aspirin Placebo - Hide

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Perioperative aspirin reduces major cardiac adverse events following non-cardiac surgery

Br J Anaesth. 2010 Mar;104(3):305-12. doi: 10.1093/bja/aeq003.

RCT General Orthopaedics Pfizer Aspirin Placebo - Hide

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Extended thromboprophylaxis with aspirin noninferior to dalteparin for THA patients

Ann Intern Med. 2013 Jun 4;158(11):800-6. doi: 10.7326/0003-4819-158-11-201306040-00004

RCT Arthroplasty Thromboembolism Lower Extremity Hip Bayer Pfizer Low-Molecular-Weight Heparin Placebo Aspirin Placebo Dalteparin Injections THA Thromboprophylaxis - Hide

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OTA2018: Similar efficacy and safety of LMWH 30mg BID and aspirin 81mg BID for VTE prophylaxis

RCT Trauma Thromboembolism Lower Extremity Pelvis Joint Acetabulum Fracture Aspirin LMWH Low Molecular Weight Heparin Prophylaxis - Hide

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OTA2017: Compliance similar between aspirin & enoxaparin in VTE prophylaxis after orthopaedic trauma

RCT General Orthopaedics Thromboembolism Trauma Appendicular Lower Extremity Lower Extremity Pelvis Joint Acetabulum Fracture Enoxaparin Aspirin Orthopaedic Prophylaxis - Hide

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AAOS2018: Additional compression pump to aspirin for thromboprophylaxis after TJA unnecessary

RCT Arthroplasty TJA Aspirin Pneumatic Compression Pump Thromboprophylaxis - Hide

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POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery

N Engl J Med. 2014 Apr 17;370(16):1504-13. doi: 10.1056/NEJMoa1401106. Epub 2014 Mar 31.

RCT General Orthopaedics Vascular Boehringer Ingelheim Clonidine Aspirin Placebo - Hide

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Polypill/Aspirin Combination Reduces Cardiovascular Events in Participants with Increased CV Risk

N Engl J Med. 2020 Nov-13;():. 10.1056/NEJMoa2028220

RCT General Orthopaedics

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Enoxaparin does not significantly reduce rates of deep vein thrombosis after TKA

J Arthroplasty. 2006 Sep;21(6 Suppl 2):139-43.

RCT Arthroplasty Axial Skeleton Spine Lower Extremity Knee Aircast Aventis Enoxaparin Aspirin Pneumatic Compression Spinal Epidural Anaesthesia - Hide

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AAOS2019: Similar efficacy and safety of LMWH 30mg BID and aspirin 81mg BID for VTE prophylaxis

RCT Trauma Thromboembolism Lower Extremity Pelvis Joint Acetabulum Fracture Aspirin LMWH Low Molecular Weight Heparin Prophylaxis - Hide

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OTA 2022: Aspirin vs Low-Molecular-Weight Heparin for Thromboprophylaxis

RCT Trauma Appendicular Lower Extremity Lower Extremity Pelvis Joint Acetabulum Fracture Enoxaparin Aspirin Low-Molecular-Weight Heparin - Hide

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Similar extended VTE prophylaxis efficacy and safety between rivaroxaban and aspirin following TJA

N Engl J Med. 2018 Feb 22;378(8):699-707

RCT Arthroplasty TJA Thromboembolism Lower Extremity Hip Knee Rivaroxaban Aspirin Oral Prophylaxis - Hide

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A Meta-analysis of Thromboembolic Prophylaxis Following Elective Total Hip Arthroplasty

J Bone Joint Surg Am. 2000 Jul;82-A(7):929-38.

Meta-analysis Arthroplasty Thromboembolism Lower Extremity Hip Heparin Aspirin Warfarin Bilateral Prophylactic Prophylaxis Replacement - Hide

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DVT Prophylaxis in Total Knee Arthroplasty

J Arthroplasty. 2001 Apr;16(3):293-300.

Meta-analysis Arthroplasty Thromboembolism Lower Extremity Knee Heparin Aspirin Warfarin Bilateral Prophylaxis Replacement TKA - Hide

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ISAKOS2017: Comparison of mechanical vs chemical thromboprophylaxis, including administration timing

RCT Arthroplasty Thromboembolism Lower Extremity Knee Rivaroxaban Aspirin Mechanical Thromboprophylaxis - Hide

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COA-ACO2018: Comparison of VTE prophylaxis of aspirin vs. extended rivaroxaban after TKA/THA

RCT Arthroplasty Thromboembolism Lower Extremity Hip Knee Rivaroxaban Aspirin Oral Prophylaxis - Hide

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No significant difference in DVT incidence between aspirin vs rivaroxaban in total knee arthroplasty

Rev Bras Ortop. 2017 Dec 6;53(1):22-27

RCT Arthroplasty Osteoarthritis Thromboembolism Lower Extremity Knee Arthritis Rivaroxaban Aspirin - Hide

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AAOS: Fondaparinux appears to be associated with elevated blood coagulation factors

RCT Arthroplasty Appendicular Lower Extremity Lower Extremity Hip Knee Fondaparinux Aspirin Blood Compression Stockings Factors Platelet Thromboprophylaxis - Hide

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Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

Ann Rheum Dis. 2004 Dec;63(12):1611-7

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Diacerein Injections Hyaluronic Acid Oral Placebo Saline - Hide

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Aspirin reduces risk of recurrence in patients with unprovoked venous thromboembolism

POISE 2 (Part 1): The safety and efficacy of aspirin following non-cardiac surgery

Perioperative aspirin reduces major cardiac adverse events following non-cardiac surgery

Extended thromboprophylaxis with aspirin noninferior to dalteparin for THA patients

OTA2018: Similar efficacy and safety of LMWH 30mg BID and aspirin 81mg BID for VTE prophylaxis

OTA2017: Compliance similar between aspirin & enoxaparin in VTE prophylaxis after orthopaedic trauma

AAOS2018: Additional compression pump to aspirin for thromboprophylaxis after TJA unnecessary

POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery

Polypill/Aspirin Combination Reduces Cardiovascular Events in Participants with Increased CV Risk

Enoxaparin does not significantly reduce rates of deep vein thrombosis after TKA

AAOS2019: Similar efficacy and safety of LMWH 30mg BID and aspirin 81mg BID for VTE prophylaxis

OTA 2022: Aspirin vs Low-Molecular-Weight Heparin for Thromboprophylaxis

Similar extended VTE prophylaxis efficacy and safety between rivaroxaban and aspirin following TJA

A Meta-analysis of Thromboembolic Prophylaxis Following Elective Total Hip Arthroplasty

DVT Prophylaxis in Total Knee Arthroplasty

ISAKOS2017: Comparison of mechanical vs chemical thromboprophylaxis, including administration timing

COA-ACO2018: Comparison of VTE prophylaxis of aspirin vs. extended rivaroxaban after TKA/THA

No significant difference in DVT incidence between aspirin vs rivaroxaban in total knee arthroplasty

AAOS: Fondaparinux appears to be associated with elevated blood coagulation factors

Hyaluronic acid injection similar in symptom & structure of knee OA vs diacerein & placebo

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