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Enoxaparin vs. Aspirin for Venous thromboembolism Prophylaxis After Hip and Knee Arthroplasty
March 2025
Enoxaparin vs. Aspirin for Venous thromboembolism Prophylaxis After Hip and Knee Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Aspirin or enoxaparin for VTE prophylaxis after primary partial, total or revision hip or knee arthroplasty: A secondary analysis from the CRISTAL cluster randomized trial.
PLoS One. 2024 Apr 16;19(4):e0298152.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Twelve thousand three hundred eighty-four (12,384) patients undergoing hip or knee arthroplasty were randomized to receive either aspirin (100 mg daily) (n=7,238) or enoxaparin (40 mg daily) (n=5,146) for 35 days after hip arthroplasty and 14 days after knee arthroplasty. The primary outcome was symptomatic venous thromboembolism (VTE) within 90 days. Secondary outcomes included joint-related reop...
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