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Aspirin vs. Enoxaparin for Preventing Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty
January 2023
Aspirin vs. Enoxaparin for Preventing Symptomatic Venous Thromboembolism in Hip or Knee Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effect of Aspirin vs Enoxaparin on Symptomatic Venous Thromboembolism in Patients Undergoing Hip or Knee Arthroplasty: The CRISTAL Randomized Trial
JAMA. 2022 Aug 23;328(8):719-727.Synopsis
9711 patients with osteoarthritis undergoing a hip or knee arthroplasty procedure at one of 31 participating hospitals were randomized (in this hospital-level, cluster-randomized, crossover, non-inferiority trial) to receive aspirin (n=5675) or enoxaparin (n=4036) for the prevention of symptomatic venous thromboembolism (VTE). The primary outcome of interest was symptomatic VTE within 90 days, inc...
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