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Efficacy of Duloxetine vs Placebo for Postspine Surgery Pain in Adult Patients
March 2025
Efficacy of Duloxetine vs Placebo for Postspine Surgery Pain in Adult Patients
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta-Analysis.
Brain Behav. 2025 Jan;15(1):e70217.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Seven studies including 273 patients undergoing various spine surgeries were included in this systematic review and meta-analysis comparing perioperative duloxetine to placebo. Pooled outcomes of interest included postoperative pain at 2, 24, and 48 hours, total analgesic consumption within 24 hours, time to first rescue analgesia, and adverse events such as nausea, vomiting, somnolence, and itchi...
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