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Osteosarcoma: methotrexate & doxorubicin versus methotrexate, etoposide & ifosfamide

Eur J Cancer. 2007 Mar;43(4):752-61. Epub 2007 Jan 30

RCT Tumour Osteosarcoma Doxorubicin Etoposide-Ifosfamide High-Dose Methotrexate Infusion Preoperative Chemotherapy - Hide

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WCO-IOF: Rituximab positively impacts QOL in patients with rheumatoid arthritis

RCT General Orthopaedics Arthritis Methotrexate Rituximab Therapy - Hide

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Etanercept with methotrexate more effectively maintains low disease activity in RA

Lancet. 2013 Mar 16;381(9870):918-29. doi: 10.1016/S0140-6736(12)61811-X. Epub 2013 Jan 17

RCT Osteoarthritis Arthritis Pfizer Methotrexate Etanercept - Hide

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Juvenile RA: Fewer disease flares with Adalimumab (TNF Antibody)

N Engl J Med. 2008 Aug 21;359(8):810-20

RCT Pediatric Orthopaedics Arthritis Abbott Methotrexate Adalimumab Placebo - Hide

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Ifosfamide not necessary in chemotherapy for nonmetastatic osteosarcoma

J Clin Oncol. 2012 Jun 10;30(17):2112-8. doi: 10.1200/JCO.2011.38.4420. Epub 2012 May 7

RCT Tumour Osteosarcoma Sarcoma Methotrexate Cisplatin Ifosfamide Doxorubicin Chemotherapy Regimen Preoperative - Hide

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RA: Addition of etanercept to methotrexate increases remission rates

Lancet. 2008 Aug 2;372(9636):375-82. Epub 2008 Jul 16

RCT General Orthopaedics Arthritis Wyeth Etanercept Oral Methotrexate - Hide

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WCO-IOF: Rituximab for rheumatoid arthritis positively impacts BMD of femoral neck

RCT General Orthopaedics Bone Femur Neck Arthritis Methotrexate Rituximab Therapy - Hide

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WCO-IOF: Methotrexate may reduce BMD loss in patients with rheumatoid arthritis

RCT General Orthopaedics Osteoporosis Arthritis Methotrexate Leflunomide - Hide

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Muramyl tripeptide in chemotherapy improves overall osteosarcoma survival

J Clin Oncol. 2008 Feb 1;26(4):633-8. doi: 10.1200/JCO.2008.14.0095

RCT Tumour Children Metastasis Osteosarcoma Women Methotrexate Cisplatin Ifosfamide Doxorubicin Chemotherapy Muramyl - Hide

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Rheumatoid arthritis: Improvement in clinical outcome similar between 4 drug therapies

Ann Intern Med. 2007 Mar 20;146(6):406-15

RCT General Orthopaedics Arthritis Centocor Schering Schering-Plough Methotrexate Sulfasalazine Infliximab Prednisone Sequential Monotherapy - Hide

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Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

Physiotherapy. 2013 Jun;99(2):126-31. doi: 10.1016/j.physio.2012.05.009. Epub 2012 Jul 24

RCT Physical Therapy & Rehab Joint Patellofemoral Pain Syndrome High-Dose Low-Dose Medical Exercise Therapy - Hide

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TNF antagonist better in treatment of early rheumatoid arthritis

Lancet. 2009 Aug 8;374(9688):459-66.

RCT General Orthopaedics Arthritis Necrosis Methotrexate Sulfasalazine Hydroxychloroquine Infliximab Factor Antagonist - Hide

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Tocilizumab more effective in reducing rheumatoid arthritis symptoms than adalimumab

Lancet. 2013 May 4;381(9877):1541-50. doi: 10.1016/S0140-6736(13)60250-0. Epub 2013 Mar 18

RCT Osteoarthritis Arthritis Hoffmann-La Roche Roche Methotrexate Adalimumab Subcutaneously Monotherapy Placebo Tocilizumab Intravenously - Hide

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High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

Eur Spine J. 2017 Nov;26(11):2851-2857

RCT Spine Stenosis Axial Skeleton Lumbar Spinal Stenosis Tranexamic Acid Bolus High-Dose TXA Interbody Fusion Low-Dose Placebo Saline - Hide

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OTA 2014: High-dose vitamin D vs. placebo in deficient patients with long bone fracture

RCT Trauma Bone Femur Humerus Tibia Fracture High-Dose Oral Placebo Vitamin - Hide

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ISAKOS2017: Similar 12-week outcome between high- and low-dose steroid for shoulder stiffness

RCT Shoulder & Elbow Upper Extremity Shoulder Stiffness Low-Dose Steroid Triamcinolone Acetonide Ultrasound-Guided Injection - Hide

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MTP-PE added to chemotherapy did not improve outcomes in metastatic osteosarcoma patients

Cancer. 2009 Nov 15;115(22):5339-48. doi: 10.1002/cncr.24566

RCT Tumour Children Metastasis Osteosarcoma Cisplatin Ifosfamide Doxorubicin Chemotherapy High-Dose Methotrexate Muramyl - Hide

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Similar ROM and clinical scores between high & low-dose corticosteroid for shoulder stiffness

J Shoulder Elbow Surg. 2017 Feb;26(2):209-215

RCT Shoulder & Elbow Upper Extremity Shoulder Stiffness Lidocaine High-Dose Low-Dose Triamcinolone Acetonide Ultrasound-Guided Intraarticular Injection - Hide

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High- and low-dose BM-MSC injection versus control for treatment of knee osteoarthritis

J Transl Med. 2016 Aug 26;14(1):246. doi: 10.1186/s12967-016-0998-2

RCT Osteoarthritis Lower Extremity Knee Arthritis Autologous Bone Marrow Injection Control High-Dose Hyaluronic Acid Low-Dose - Hide

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No difference between high- and low-dose corticosteroid injection for shoulder pain

Arch Phys Med Rehabil. 2011 Dec;92(12):1951-60. doi: 10.1016/j.apmr.2011.06.033. Epub 2011 Oct 25

RCT Shoulder & Elbow Upper Extremity Shoulder Bone Subacromial Pain Lidocaine Corticosteroid Low-Dose Placebo Subacromial Injection Triamcinolone Acetonide - Hide

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Osteosarcoma: methotrexate & doxorubicin versus methotrexate, etoposide & ifosfamide

WCO-IOF: Rituximab positively impacts QOL in patients with rheumatoid arthritis

Etanercept with methotrexate more effectively maintains low disease activity in RA

Juvenile RA: Fewer disease flares with Adalimumab (TNF Antibody)

Ifosfamide not necessary in chemotherapy for nonmetastatic osteosarcoma

RA: Addition of etanercept to methotrexate increases remission rates

WCO-IOF: Rituximab for rheumatoid arthritis positively impacts BMD of femoral neck

WCO-IOF: Methotrexate may reduce BMD loss in patients with rheumatoid arthritis

Muramyl tripeptide in chemotherapy improves overall osteosarcoma survival

Rheumatoid arthritis: Improvement in clinical outcome similar between 4 drug therapies

Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

TNF antagonist better in treatment of early rheumatoid arthritis

Tocilizumab more effective in reducing rheumatoid arthritis symptoms than adalimumab

High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

OTA 2014: High-dose vitamin D vs. placebo in deficient patients with long bone fracture

ISAKOS2017: Similar 12-week outcome between high- and low-dose steroid for shoulder stiffness

MTP-PE added to chemotherapy did not improve outcomes in metastatic osteosarcoma patients

Similar ROM and clinical scores between high & low-dose corticosteroid for shoulder stiffness

High- and low-dose BM-MSC injection versus control for treatment of knee osteoarthritis

No difference between high- and low-dose corticosteroid injection for shoulder pain

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Emerging Treatments

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Evidence Series

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