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Low-Dose Short-Term NSAID (Ketorolac) on Cytokine Levels After Orthopaedic Polytrauma
November 2024
Low-Dose Short-Term NSAID (Ketorolac) on Cytokine Levels After Orthopaedic Polytrauma
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Does Scheduled Low-Dose Short-Term NSAID (Ketorolac) Modulate Cytokine Levels After Orthopaedic Polytrauma? A Secondary Analysis of a Randomized Clinical Trial.
J Orthop Trauma. 2024 01-Jul;():. 10.1097/BOT.0000000000002807Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Seventy orthopedic polytrauma patients were randomized to receive either 15 mg of intravenous ketorolac every 6 hours (n=35) or 2 mL of intravenous saline (n=35) for up to 5 inpatient days. The primary outcome was daily cytokine concentrations, including IL-1a, IL-1b, IL-6, IL-10, and prostaglandin E2 (PGE2). Secondary outcomes assessed included hospital and ICU length of stay (LOS), pulmonary com...
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