Rotator cuff tendinopathy affects 1 in 5 people and is a common cause of shoulder pain and weakness (Bury et al., 2018; Yamamoto et al., 2010). The prevalence of rotator cuff tendinopathy increases with age (Yamamoto et al., 2010). Rotator cuff tendinopathy is a chronic degenerative condition and is associated with excessive use of rotator cuff tendons and muscles or a tear (Lewis, 2009). Conservetive strategies including patient education, exercise and physical therapy are recommended and mostly performed in management of rotator cuff tendinopathy (Tashjian, 2011; Bury et al., 2018).' Prolotherapy is a regenerative injection of a solution to the painful and degenerated sites to promote local healing of injured tissues and has been found effective and safe in treatment for chronic musculoskeletal conditions including knee osteoarthritis (https://myorthoevidence.com/Blog/Show/124), nonsurgical sacroiliac pain, lateral epicondylosis, plantar fasciopathy and rotator cuff disorders ranging from tendinosis to small full-thickness or....