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A Single-Dose of COVID-19 Vaccine May Not Protect Us from the SARS-CoV-2 Delta Variant: An Evidence Review

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June 14, 2021

A Single-Dose of COVID-19 Vaccine May Not Protect Us from the SARS-CoV-2 Delta Variant: An Evidence Review

Vol: 4| Issue: 6| Number:2| ISSN#: 2563-559X

Authored By: Meng Zhu, Mohit Bhandari On Behalf of OrthoEvidence

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A variant of concern (VOC) refers to “a variant for which there is evidence of an increase in transmissibility, more severe disease (e.g., increased hospitalizations or deaths), significant reduction in neutralization by antibodies generated during previous infection or vaccination, reduced effectiveness of treatments or vaccines, or diagnostic detection failures” [United States Centers for Disease Control and Prevention (US CDC)]. The World Health Organization (WHO) proposes that a VOC may pose serious risks at “a degree of global public health significance” (WHO). During the press briefing on May 10th, 2021, the WHO has officially declared the SARS-CoV-2 B.1.617.2 variant, one of the 3 sub-lineages of B.1.167 (i.e., B.1.617.1, B.1.617.2, and B.1.617.3), as a VOC (WHO). The B.1.617.1 is designated as a variant of interest (VOI, defined by the CDC as a variant with specific genetic markers that have been associated with changes to receptor binding, reduced....
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