COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Efficacy of combined IV/IA TXA administration in simultaneous bilateral TKA

Knee. 2015 Mar;22(2):131-5

IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective

J Arthroplasty. 2017 Jan;32(1):37-42

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

AAOS2017: Similar efficacy between IA TXA and IV TXA in total knee arthroplasty

IV and topical tranexamic acid protocols reduce blood loss and transfusion needs in THA

J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.023

Combined IV-IA TXA further reduces blood loss versus IV TXA alone, but does not reduce transfusion

BMC Musculoskelet Disord. 2018 Sep 7;19(1):321. doi: 10.1186/s12891-018-2181-9

Intravenous and topical tranexamic acid have similar efficacy in TKA

Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.

AAOS 2016: Differences in blood loss noted with various TXA administration methods in TKA

COA/ICORS2019: Blood loss, Hb drop, and transfusion rate similar between IA TXA and IV TXA in TKA

Similar reduction in total blood loss with intravenous/articular TXA administration in TKA

Arch Orthop Trauma Surg. 2015 Apr;135(4):573-88.

Similar effect of intra-articular vs IV TXA on Hb drop, LoS, and transfusion following TKA

J Arthroplasty. 2017 Jan;32(1):28-32

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

AAOS2019: Similar outcomes with oral and IV TXA for blood loss in thoracolumbar spinal fusion

IV and topical TXA superior to placebo for hematological outcomes after PLIF

World Neurosurg. 2019 Feb;122:e821-e827.

AAOS 2016: Oral and IV TXA demonstrate equivalent efficacy for blood loss in THA

Assessment of IV, IA, and oral tranaexamic acid safety in total joint arthroplasty

J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.023