IV and/or IA TXA effective in navigated TKA, but combined IV-IA TXA not more effective
Combined Administration of IV and Topical Tranexamic Acid is Not Superior to Either Individually in Primary Navigated TKAJ Arthroplasty. 2017 Jan;32(1):37-42
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200 patients scheduled for primary, navigated total knee arthroplasty were randomized to one of four groups: intravenous (IV) tranexamic acid administration, intraarticular (IV) TXA administration, combined IV-IA TXA administration, or administration of placebo saline. Patients were assessed for blood loss variables, included total blood loss, postoperative blood loss, haemoglobin and haematocrit ...
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