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ACE Report #9031
Ace Report Cover Arthroplasty

Lower blood loss with IV+IA TXA versus IV TXA alone following total knee arthroplasty

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Combined Intra-Articular and Intravenous Tranexamic Acid Reduces Blood Loss in Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial

J Bone Joint Surg Am. 2016 May 18;98(10):835-41

Contributing Authors: CS Nielsen Ø Jans T Ørsnes NB Foss A Troelsen H Husted

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60 patients scheduled for unilateral total knee arthroplasty were randomized to either combined intravenous and intra-articular tranexamic acid administration, or intravenous TXA administration alone. The purpose of this study was to determine if combined IV-IA TXA administration offered lower 24-hour blood loss compared to IV administration alone. In addition to significantly lower 24-hr blood lo...

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