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ACE Report #8648
Ace Report Cover Arthroplasty

AAOS 2016: IV+IA TXA significantly reduces blood loss compared to IV TXA alone in TKA

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Combined Intra-Articular and Intravenous Tranexamic Acid Significantly Reduce Blood Loss in Knee Arthroplasty

Contributing Authors: CS Nielsen O Jans NB Foss T Oersnes A Troelsen H Husted

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


60 patients undergoing total knee arthroplasty were randomized to receive either both intravenous (IV) and intra-articular (IA) tranexamic acid administration, or intravenous administration alone. The study was conducted in order to determine whether the addition of IA TXA to IV TXA was associated with a significant reduction in total blood loss. Findings indicated that the combined administration...

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