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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1517-28

Meta-analysis General Orthopaedics Lower Extremity Knee Pain Bupivacaine Analgesia Analgesic Arthroscopic Surgery Arthroscopy IA Placebo Reduction Single-Dose - Hide

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No difference in infection risk with single vs. multidose antibiotics in orthopedic implant surgery

Clin Orthop Relat Res. 2019 Jul;477(7):1577-1590.

Meta-analysis General Orthopaedics Infection Antibiotics Arthroplasty Implants Orthopedic Pre-Operative Prophylactic Single-Dose - Hide

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Single-Dose IA ropivacaine reduces pain up to 8 hours post arthroscopic knee surgery

Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1651-9

Meta-analysis Arthroplasty Lower Extremity Knee Pain Analgesic Anterior Cruciate Arthroscopic Arthroscopy IA Ropivacaine Placebo Post-Operative Post-Surgery Single-Dose - Hide

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Single-dose epidural DepoDur is a safe and effective analgesic after knee arthroplasty

J Bone Joint Surg Am. 2006 Feb;88(2):273-81

RCT Arthroplasty Lower Extremity Knee Pain Morphine Depodur Extended-Release Sham Epidural Injection Single-Dose - Hide

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Antiresorptive effects of single zoledronate dose are sustained for 3 years

J Bone Miner Res. 2010 Oct;25(10):2251-5

RCT Metabolic Disorders Osteopenia Postmenopausal Women Zoledronate Placebo - Hide

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Evaluating single-dose betamethasone for analgesia after outpatient knee arthroscopy

J Anesth. 2016 Oct;30(5):803-10

RCT Sports Medicine Lower Extremity Knee Betamethasone Anaesthesia Analgesia Arthroscopy Induction Of Anesthesia Intravenous Injection Placebo - Hide

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OTA 2014: High-dose vitamin D vs. placebo in deficient patients with long bone fracture

RCT Trauma Bone Femur Humerus Tibia Fracture High-Dose Oral Placebo Vitamin - Hide

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Combination of dexketoprofen/tramadol reduces postoperative pain vs. monotherapy in THA

Br J Anaesth. 2016 Feb;116(2):269-76.

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Arthritis Pain Menarini Tramadol Metamizole Dexketoprofen Monotherapy Multiple-Dose Placebo Medication Single-Dose - Hide

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Knee OA: Single (1200 mg) and 3/day (400 mg) dose chondroitin are equivalent

Osteoarthritis Cartilage. 2012 Oct 8. pii: S1063-4584(12)00992-2. doi: 10.1016/j.joca.2012.09.017

RCT Osteoarthritis Lower Extremity Knee Arthritis Innovative Neurotronics Paracetamol Chondroitin Gel Oral Placebo Sulfate - Hide

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Single-shot dose and continuous infusion of TXA have similar efficacy in primary TKA

Arch Orthop Trauma Surg. 2015 Apr;135(4):465-71

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Bolus Continuous Infusion Induction Of Anaesthesia Tourniquet Inflation TXA - Hide

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No significant effect of vitamin D3 supplementation on fracture union in hypovitaminosis patients

Bone Joint J. 2017 Nov;99-B(11):1520-1525

RCT Trauma Bone Femur Humerus Tibia Fracture Placebo Vitamin D3 - Hide

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AAOS 2016: Single-dose vitamin D does not reduce nonunion rate in acute long bone fracture

RCT Trauma Bone Femur Humerus Tibia Fracture Nonunion Placebo Vitamin - Hide

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TKA: preoperative methylprednisolone effective for pain and recovery

Br J Anaesth. 2011 Feb;106(2)

RCT Arthroplasty Lower Extremity Knee Pain Methylprednisolone Sufentanil Oxycodone Ondansetron High-Dose Placebo Preoperatively TKA - Hide

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Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

Int J Surg. 2019 May;65:45-51.

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Inflammation Blood Loss Oral TXA - Hide

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Preoperative dose of etoricoxib reduces postoperative morphine consumption

Acta Orthop. 2012 Dec;83(6):642-7. doi: 10.3109/17453674.2012.747053. Epub 2012 Nov 9

RCT Arthroplasty Women Lower Extremity Knee Pain Merck Etoricoxib Morphine Anaesthesia Arthroscopy Induction Of Anesthesia Placebo Preoperative - Hide

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Single preoperative dose of pregabalin 150mg offers short analgesic efficacy in PLIF cases

J Clin Anesth. 2016 Jun;31:149-53

RCT Spine Axial Skeleton Lumbar Morphine Diazepam Pregabalin Analgesia Placebo Preoperative - Hide

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Effects of 2.5mg zoledronate are long-lasting and similar to 5mg dose in osteopenic women

J Bone Miner Res. 2014 Jan;29(1):166-72. doi: 10.1002/jbmr.2009.

RCT General Orthopaedics Osteopenia Postmenopausal Women Axial Skeleton Spine Spine Lumbar Lower Extremity Hip Novartis Roche Zoledronate Infusion Placebo - Hide

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THR: Single pamidronate dose doesn't prevent development of osteolytic lesions

J Bone Joint Surg Br. 2006 Oct;88(10):1309-15.

RCT Arthroplasty Lesion Lower Extremity Hip Placebo Single Intravenous Infusion Of Pamidronate - Hide

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TKA: LIA effective short term analgesia in terms of VAS, morphine consumption and function

Knee. 2014 Jun;21(3):636-46

Meta-analysis Arthroplasty Lower Extremity Knee Morphine Anaesthesia Analgesic Anesthetic Control LIA Local Infiltration Analgesia Placebo Replacement Single-Dose TKA TKR - Hide

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OTA2017: Antibiotic prophylaxis does not reduce infection rate after lower-limb implant removal

RCT Foot & Ankle Foot Infection Wound Lower Extremity Ankle Knee Lower Leg Fracture Antibiotic Prophylaxis Implant Intravenous Cephalosporin Intravenous Placebo Prophylactic - Hide

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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

No difference in infection risk with single vs. multidose antibiotics in orthopedic implant surgery

Single-Dose IA ropivacaine reduces pain up to 8 hours post arthroscopic knee surgery

Single-dose epidural DepoDur is a safe and effective analgesic after knee arthroplasty

Antiresorptive effects of single zoledronate dose are sustained for 3 years

Evaluating single-dose betamethasone for analgesia after outpatient knee arthroscopy

OTA 2014: High-dose vitamin D vs. placebo in deficient patients with long bone fracture

Combination of dexketoprofen/tramadol reduces postoperative pain vs. monotherapy in THA

Knee OA: Single (1200 mg) and 3/day (400 mg) dose chondroitin are equivalent

Single-shot dose and continuous infusion of TXA have similar efficacy in primary TKA

No significant effect of vitamin D3 supplementation on fracture union in hypovitaminosis patients

AAOS 2016: Single-dose vitamin D does not reduce nonunion rate in acute long bone fracture

TKA: preoperative methylprednisolone effective for pain and recovery

Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

Preoperative dose of etoricoxib reduces postoperative morphine consumption

Single preoperative dose of pregabalin 150mg offers short analgesic efficacy in PLIF cases

Effects of 2.5mg zoledronate are long-lasting and similar to 5mg dose in osteopenic women

THR: Single pamidronate dose doesn't prevent development of osteolytic lesions

TKA: LIA effective short term analgesia in terms of VAS, morphine consumption and function

OTA2017: Antibiotic prophylaxis does not reduce infection rate after lower-limb implant removal

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