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Collagenase injections: A non-surgical modality in treating Dupuytren's Disease
March 2013
Collagenase injections: A non-surgical modality in treating Dupuytren's Disease
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Injectable collagenase Clostridium histolyticum: A new nonsurgical treatment for Dupuytren's disease
Journal of Hand Surgery American; 2010; 35(A); 2027-2038Synopsis
66 patients with contractures, affecting either the metacarpophalangeal (MCP) or proximal interphalangeal (PIP) joints, were randomized to receive Xiaflex (collagenase clostridium histolyticum) or placebo local injection. The results of the 9-month long trial indicated that patients who received Xiaflex displayed significantly greater range of motion and a significantly decreased degree of joint c...
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