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Efficacy of various tranexamic acid administration techniques to reduce blood loss in TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Dec;22(12):3181-90.

Meta-analysis Arthroplasty Lower Extremity Knee Tranexamic Acid Injection Blood Loss Control Information Intravenous TXA Placebo TKA Transfusion - Hide

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Tranexamic acid efficacious in reducing blood loss and transfusion in bilateral TKA

J Arthroplasty. 2016 Nov;31(11):2471-2475

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Smith & Nephew Zimmer NexGen Tranexamic Acid Bilateral Blood Loss Fixed Saline Tourniquet Inflation Transfusion - Hide

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Tranexamic acid reduces blood transfusion requirements during surgery

BMJ. 2012 May 17;344:e3054. doi: 10.1136/bmj.e3054

Meta-analysis Metabolic Disorders Tranexamic Acid Blood Transfusion Placebo - Hide

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Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

J Arthroplasty. 2016 Nov;31(11):2452-2457

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Intracapsular Injection Intravenous Injections Saline TXA - Hide

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Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA

Clin Orthop Relat Res. 2011 Oct;469(10):2874-80. Epub 2011 Apr 22

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Tranexamic Acid Blood Loss Blood Transfusion Oral Placebo TKA - Hide

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Reduced blood loss during early postoperative period after TKA with IV tranexamic acid

Knee. 2006 Mar;13(2):106-10. Epub 2006 Feb 17

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Intravenously Prosthesis Cementation Saline TKA - Hide

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Tranexamic acid is effective in reducing blood loss, while maintaining safety, in THA

Arch Orthop Trauma Surg. 2013 Jul;133(7):1017-27. doi: 10.1007/s00402-013-1761-2. Epub 2013 Apr 25

Meta-analysis Arthroplasty Lower Extremity Hip Tranexamic Acid Allogenic Blood Loss Blood Transfusion Control Placebo Reduction Replacement THA TXA - Hide

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TKA: Drain-clamping with tranexamic acid decreased drained blood volume/ transfusions

BMC Musculoskelet Disord. 2012 Jul 20;13:124. doi: 10.1186/1471-2474-13-124

RCT Arthroplasty Lower Extremity Knee Arthritis Tranexamic Acid Blood Drain Non-Clamping Placebo TKA - Hide

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AAOS 2016: Interim evaluation of tranexamic acid vs placebo in acetabular fracture surgery

RCT Trauma Joint Acetabulum Fracture Tranexamic Acid Placebo - Hide

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IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Topical TXA Transfusion - Hide

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TKR: blood conservation similar between one and two injections of tranexamic acid

J Bone Joint Surg Br. 2012 Jul;94(7):932-6

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Minimally Invasive Placebo Replacement TEA TKR - Hide

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Tranexamic acid effectively reduces blood loss after TKA without adverse events

Knee Surg Sports Traumatol Arthrosc. 2014 Aug;22(8):1849-58

Meta-analysis Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Control Placebo Replacement TKA TKR - Hide

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TKA: Topical Fibrin Spray and Tranexamic acid reduce blood loss

J Bone Joint Surg Br. 2007 Mar;89(3):306-9

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Control Pharmacological Replacement Topical Fibrin Spray - Hide

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Tranexamic acid decreases blood loss & transfusion needs compared to knee flexion post-TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Nov;22(11):2756-62.

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Rottapharm Tranexamic Acid Blood Loss Control Flexion Operative Pharmacological Transfusion - Hide

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Tranexamic acid is safe and effective in reducing blood loss in TKA

J Bone Joint Surg Am. 2012 Jul 3;94(13):1153-9. doi: 10.2106/JBJS.K.00873

Meta-analysis Arthroplasty Lower Extremity Knee Tranexamic Acid Anticoagulant Blood Loss Blood Transfusion Control Placebo Pneumatic Tourniquet TKA - Hide

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ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction

RCT Sports Medicine Joint Ligament Hemarthrosis Tranexamic Acid Anterior Cruciate Injection Control IA TXA Reconstruction - Hide

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Efficacy of Floseal vs. tranexamic acid vs. control for bleeding control in patients undergoing TKA

Clinics (Sao Paulo). 2019 Nov 25;74:e1186.

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Control Floseal Tourniquet - Hide

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Reduced blood loss in TKA through intra-articular tranexamic acid with dilute epinephrine

J Arthroplasty. 2015 Aug;30(8):1354-8.

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Tranexamic Acid Epinephrine Injection Blood Loss Drain Saline Solution TKA TXA - Hide

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Intra-articular TXA may reduce blood loss following unilateral TKA

Eur J Orthop Surg Traumatol. 2015 Jan;25(1):135-9.

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Tranexamic Acid Injection Blood Loss Fascial Closure Operative Reduction Saline TXA - Hide

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COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

RCT Arthroplasty Lower Extremity Hip Tranexamic Acid Blood Loss IV TXA - Hide

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Efficacy of various tranexamic acid administration techniques to reduce blood loss in TKA

Tranexamic acid efficacious in reducing blood loss and transfusion in bilateral TKA

Tranexamic acid reduces blood transfusion requirements during surgery

Intracapsular and intravenous administration for TXA similar in efficacy and safety in TKA

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA

Reduced blood loss during early postoperative period after TKA with IV tranexamic acid

Tranexamic acid is effective in reducing blood loss, while maintaining safety, in THA

TKA: Drain-clamping with tranexamic acid decreased drained blood volume/ transfusions

AAOS 2016: Interim evaluation of tranexamic acid vs placebo in acetabular fracture surgery

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

TKR: blood conservation similar between one and two injections of tranexamic acid

Tranexamic acid effectively reduces blood loss after TKA without adverse events

TKA: Topical Fibrin Spray and Tranexamic acid reduce blood loss

Tranexamic acid decreases blood loss & transfusion needs compared to knee flexion post-TKA

Tranexamic acid is safe and effective in reducing blood loss in TKA

ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction

Efficacy of Floseal vs. tranexamic acid vs. control for bleeding control in patients undergoing TKA

Reduced blood loss in TKA through intra-articular tranexamic acid with dilute epinephrine

Intra-articular TXA may reduce blood loss following unilateral TKA

COA2017: IA TXA and IV TXA demonstrate similar results for blood loss in total hip arthroplasty

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