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Effective pain management with IA clonidine for up to 4 hours after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Sep;22(9):2076-84

Meta-analysis General Orthopaedics Lower Extremity Knee Pain Clonidine Analgesia Arthroscopic Arthroscopy Injections General Anaesthesia IA Immediate Placebo Post-Operative Single-Dose - Hide

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POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery

N Engl J Med. 2014 Apr 17;370(16):1504-13. doi: 10.1056/NEJMoa1401106. Epub 2014 Mar 31.

RCT General Orthopaedics Vascular Boehringer Ingelheim Clonidine Aspirin Placebo - Hide

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Tibial fractures: Alpha-BSM comparable to autogenous bone graft in preventing subsidence

J Bone Joint Surg Am. 2008 Oct;90(10):2057-61

RCT Trauma Women Bone Iliac Tibia Plateau Fracture Tibial Plateau DePuy ETEX Autogenous Bone Graft Autogenous Iliac Bone Graft Bioresorbable Calcium Phosphate Cement Internal Fixation Open Reduction - Hide

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Dronabinol does not cause metabolic disturbances in managing chronic neuropathy pain

Clin Ther. 2015 Oct 1;37(10):2267-74. doi: 10.1016/j.clinthera.2015.07.023

RCT Cannabis Pain Neuropathy Placebo - Hide

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Epoetin-alpha injection effective in reducing need for allogenic blood transfusions

J Bone Joint Surg Br. 2008 Aug;90(8):1079-83

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Knee Arthritis Autologous Blood Injections Epoetin-Alpha Post-Operative Pre-Operative Replacement Retransfusion - Hide

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Bioresorbable calcium phosphate paste ([alpha]-BSM) in treatment of calcaneal fractures

J Trauma. 2009 Oct;67(4):875-82.

RCT Trauma Bone Calcaneus Fracture DePuy Bioresorbable Calcium Phosphate Internal Fixation Open Reduction ORIF Paste - Hide

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Golimumab treatment provides superior treatment of rheumatoid arthritis

Lancet. 2009 Jul 18;374(9685):210-21. Epub 2009 Jun 26

RCT General Orthopaedics Tumour Arthritis Necrosis Golimumab Injection Inhibitor Placebo - Hide

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Lumbar fusion: rhBMP-2 reduces rate of fusion failure and reoperation

Arch Orthop Trauma Surg. 2012 Dec;132(12):1725-40. doi: 10.1007/s00402-012-1607-3. Epub 2012 Sep 1

Meta-analysis Spine Lumbar Bone Iliac Autogenous Iliac Crest Bone Graft Fusion ICBG Recombinant Human Bone Morphogenetic Protein-2 - Hide

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Perioperative administration of cyclooxygenase-2 inhibitors reduces pain in TKA patients

J Arthroplasty. 2013 Feb;28(2):207-213.e2. doi: 10.1016/j.arth.2012.04.008. Epub 2012 Jun 7

Meta-analysis Arthroplasty Lower Extremity Knee Pain Analgesia Opioid TKA - Hide

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Intrathecal and intravenous clonidine with bupivacaine in children undergoing surgery

Paediatr Anaesth. 2011 Apr;21(4):399-405. doi: 10.1111/j.1460-9592.2011.03543.x

RCT Pediatric Orthopaedics Children Orthopaedic Surgery Lower Extremity Hip Knee Propofol Clonidine Hyperbaric Bupivacaine Intrathecally Intrathecal Bupivacaine Intravenously Orthopedic Saline - Hide

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Efficacy and safety of rhBMP-2 compared to iliac crest bone graft in spinal fusion

Ann Intern Med. 2013 Jun 18;158(12):877-89. doi: 10.7326/0003-4819-158-12-201306180-00005

Meta-analysis Spine Axial Skeleton Bone Iliac Medtronic Bone Grafts Fusion Surgery ICBG Iliac Crest Bone Graft IPD Observational Recombinant Human Bone Morphogenetic Protein-2 Spinal Fusion - Hide

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ISASS: Use of rhBMP-2 and autologous bone in PLIF display similar clinical outcomes

RCT Spine Lumbar Autologous Bone Filled PEEK Cages PLIF Recombinant Human Bone Morphogenic Protein - Hide

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Diclofenac, ibuprofen, and celecoxib improve function and pain in knee OA patients

Osteoarthritis Cartilage. 2013 Sep;21(9):1400-8

RCT Osteoarthritis Lower Extremity Knee Arthritis Inflammation Pain Ibuprofen Celecoxib Diclofenac Nonsteroidal TKA - Hide

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Alpha Lipoic Acid Improves Outcomes In Patients Receiving Pulsed Radiofrequency for Radicular Pain

Medicine (Baltimore). 2021 18-Jun;():. 10.1097/MD.0000000000026344

RCT Spine Axial Skeleton Hospira Pulsed Radiofrequency Chronic Lumbar Spine Electrical modality Dietary supplement Alpha lipoic acid NeuroTherm NeuroTherm EVA Pharma NeuroTherm - Hide

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rhBMP-2 is safe and improves outcomes in open tibial fractures

J Bone Joint Surg Am. 2002 Dec;84-A(12):2123-34

RCT Trauma Bone Tibia Fracture Wyeth Control Intramedullary Standard Of Care - Hide

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AAOS: rhBMP-2 in Posterior Lumbar Interbody Fusion

RCT Spine Lumbar Autologous Bone Filled Interbody Fusion Pedicle Screws PEEK Cages Posterior Stabilization - Hide

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The effect of rhBMP-2 in single-level posterior lumbar interbody arthrodesis

J Bone Joint Surg Am. 2013 May 15;95(10):873-80. doi: 10.2106/JBJS.L.00137

RCT Spine Discs Sciatica Spondylolisthesis Lumbar Bone Iliac Instrumentation Rod System Instrumented Interbody Arthrodesis Polyetheretherketone Cages Recombinant Human Bone Morphogenetic Protein-2 Titanium - Hide

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Interspinous process device not favorable over decompression for LSS at 2 years

Eur Spine J. 2015 Oct;24(10):2295-305

RCT Spine Stenosis Axial Skeleton Lumbar Spinal Stenosis Paradigm Spine Decompression IPD - Hide

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rhBPM-2 with allograft effective for reconstruction of diaphyseal tibial fractures

J Bone Joint Surg Am. 2006 Jul;88(7):1431-41.

RCT Trauma Bone Tibia Fracture Wyeth Allograft Autogeneous Bone Graft Cortical Recombinant Human Bone Morphogenetic Protein-2 Reconstruction - Hide

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Efficacy of ketamine, pregabalin, and combined analgesia in total hip arthroplasty

Anaesthesia. 2014 Jan;69(1):46-52

RCT Arthroplasty Lower Extremity Hip Morphine Anaesthesia Bolus IV Ketamine Infusion Placebo Preoperative Oral Pregabalin Skin Closure - Hide

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Effective pain management with IA clonidine for up to 4 hours after knee arthroscopy

POISE 2 (Part 2): The safety and efficacy of clonidine following non-cardiac surgery

Tibial fractures: Alpha-BSM comparable to autogenous bone graft in preventing subsidence

Dronabinol does not cause metabolic disturbances in managing chronic neuropathy pain

Epoetin-alpha injection effective in reducing need for allogenic blood transfusions

Bioresorbable calcium phosphate paste ([alpha]-BSM) in treatment of calcaneal fractures

Golimumab treatment provides superior treatment of rheumatoid arthritis

Lumbar fusion: rhBMP-2 reduces rate of fusion failure and reoperation

Perioperative administration of cyclooxygenase-2 inhibitors reduces pain in TKA patients

Intrathecal and intravenous clonidine with bupivacaine in children undergoing surgery

Efficacy and safety of rhBMP-2 compared to iliac crest bone graft in spinal fusion

ISASS: Use of rhBMP-2 and autologous bone in PLIF display similar clinical outcomes

Diclofenac, ibuprofen, and celecoxib improve function and pain in knee OA patients

Alpha Lipoic Acid Improves Outcomes In Patients Receiving Pulsed Radiofrequency for Radicular Pain

rhBMP-2 is safe and improves outcomes in open tibial fractures

AAOS: rhBMP-2 in Posterior Lumbar Interbody Fusion

The effect of rhBMP-2 in single-level posterior lumbar interbody arthrodesis

Interspinous process device not favorable over decompression for LSS at 2 years

rhBPM-2 with allograft effective for reconstruction of diaphyseal tibial fractures

Efficacy of ketamine, pregabalin, and combined analgesia in total hip arthroplasty

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