IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA
A randomized comparative study of topical versus intravenous tranexamic acid administration in enhanced recovery after surgery (ERAS) total knee replacementJ Orthop. 2016 Mar 26;13(3):127-31
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90 patients scheduled for total knee arthroplasty were randomized to one of three groups; one group was administered 1g of tranexamic acid intravenously; one group was administered 1g of tranexamic acid topically; one group underwent surgery without tranexamic acid administration. Calculated blood loss, the incidence of transfusion, and complications, which included venous thromboembolic events we...
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