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Zoledronic acid in the prevention and treatment of glucocorticoid-induced osteoporosis

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Ace Report Cover
May 2013

Zoledronic acid in the prevention and treatment of glucocorticoid-induced osteoporosis

Vol: 2| Issue: 4| Number:77| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Zoledronic acid and risedronate in the prevention and treatment of glucocorticoid-induced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial

Lancet. 2009 Apr 11;373(9671):1253-63

Contributing Authors:
DM Reid JP Devogelaer K Saag C Roux CS Lau JY Reginster P Papanastasiou A Ferreira F Hartl T Fashola P Mesenbrink PN Sambrook HORIZON investigators

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Synopsis

833 patients, undergoing treatment with glucocorticoids for 12 months, were randomized to receive zoledronic acid or risedronate in this double blind, double dummy trial. This study assessed the non-inferiority of one injection of zoledronic acid for the prevention and treatment of glucocorticoid induced osteoporosis compared to the daily oral risedronate dosage. Following the one year treatment p...

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